Combination of PI-RADS score and mRNA urine test—A novel scoring system for improved detection of prostate cancer

• Published in: PloS one Vol. 17; no. 8; p. e0271981
• Main Authors: Katzendorn, Olga, von Klot, Christoph A. J, Mahjoub, Samy, Faraj Tabrizi, Pouriya, Harke, Nina N, Tezval, Hossein, Hellms, Susanne, Hennenlotter, Jörg, Baig, Mirza S, Stenzl, Arnulf, Seith, Ferdinand, Lafos, Marcel, Kuczyk, Markus A, Rausch, Steffen, Peters, Inga
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 12.08.2022; Public Library of Science (PLoS)
• Subjects: Analysis; Biology and Life Sciences; Biomarkers; Biopsy; Cancer; Decision analysis; Diagnosis; Feasibility studies; Histology; Magnetic resonance imaging; Medicine and Health Sciences; Messenger RNA; mRNA; Observational studies; Patients; Physical Sciences; Prostate cancer; Regression analysis; Research and Analysis Methods; Sensitivity analysis; Urine; Variance analysis; Germany; United States > US; Netherlands

Available tests to detect clinically significant prostate cancer frequently lead to overdiagnosis and overtreatment. Our study assessed the feasibility of combining a urinary biomarker-based risk score (SelectMDx.sup.®) and multiparametric MRI outcomes in order to identify patients with prostate can...