Large eddy simulation of LDL surface concentration in a subject specific human aorta

• Published in: Journal of biomechanics Vol. 45; no. 3; pp. 537 - 542
• Main Authors: Lantz, Jonas, Karlsson, Matts
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 02.02.2012; Elsevier; Elsevier Limited
• Subjects: Accumulation; Aorta; Aorta - metabolism; Aorta - pathology; Atherosclerosis; Atherosclerosis (general aspects, experimental research); Atherosclerosis - physiopathology; Biological and medical sciences; Blood and lymphatic vessels; Blood flow; Blood Flow Velocity - physiology; Cardiology. Vascular system; Computer Simulation; Computerized, statistical medical data processing and models in biomedicine; Coronary vessels; Correlation; Diastole; Disturbed flow; Geometry; Human; Humans; Large eddy simulation; Lipoproteins, LDL - chemistry; Low-density lipoprotein; Magnetic resonance imaging; Medical sciences; Models and simulation; Models, Cardiovascular; Permeability; Physical Medicine and Rehabilitation; Physiology; Reynolds number; Stress concentration; Stress, Mechanical; Turbulence models; Veins & arteries; Velocity; Wall shear stress; Low-density lipoprotein; Wall shear stress; Atherosclerosis; Disturbed flow; Human; Pathogenesis; Cardiovascular disease; Modeling; Artery; Vascular disease; Biomechanics; Lipoprotein LDL; Large eddy simulation; Mechanical stress; Blood vessel; Shear stress; Aorta; Circulatory system; Vascular wall; Biomedical engineering

The development of atherosclerosis is correlated to the accumulation of lipids in the arterial wall, which, in turn, may be caused by the build-up of low-density lipoproteins (LDL) on the arterial surface. The goal of this study was to model blood flow within a subject specific human aorta, and to s...