Uncertainty quantification in ToxCast high throughput screening

• Published in: PloS one Vol. 13; no. 7; p. e0196963
• Main Authors: Watt, Eric D., Judson, Richard S.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 25.07.2018; Public Library of Science (PLoS)
• Subjects: Analysis; BASIC BIOLOGICAL SCIENCES; Biocompatibility; Biological activity; Biology and Life Sciences; Chemicals; colorimetric assays; Computation; Computer applications; curve fitting; Data analysis; Dosimetry; Environmental protection; Environmental toxicology; estrogen; Estrogens; High-throughput screening; Inspection; Internet; kidneys; Laws, regulations and rules; Medical screening; Medicine and Health Sciences; Normal distribution; Organic chemistry; Parameter estimation; Physical Sciences; predictive toxicology; Regression analysis; Resampling; Research and Analysis Methods; Risk assessment; Statistical methods; Stem cells; Toxicity; Toxicology; United States; North Carolina; New York; United States > US

High throughput screening (HTS) projects like the U.S. Environmental Protection Agency's ToxCast program are required to address the large and rapidly increasing number of chemicals for which we have little to no toxicity measurements. Concentration-response parameters such as potency and effic...