Microneedle patches: Usability and acceptability for self-vaccination against influenza

• Published in: Vaccine Vol. 32; no. 16; pp. 1856 - 1862
• Main Authors: Norman, James J., Arya, Jaya M., McClain, Maxine A., Frew, Paula M., Meltzer, Martin I., Prausnitz, Mark R.
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.04.2014; Elsevier; Elsevier Limited
• Subjects: Acceptability; Adult; adults; Allergy and Immunology; Applied microbiology; Bias; Biological and medical sciences; Costs; Fear & phobias; Female; Fundamental and applied biological sciences. Psychology; Humans; Hypotheses; Immunization; Influenza; Influenza Vaccines - administration & dosage; Influenza, Human - prevention & control; Injections, Intradermal - instrumentation; intramuscular injection; Male; Methods; Microbiology; Microneedle, Human study; Middle Aged; Mortality; Needles; Patient Preference; patients; placebos; Regulatory approval; Self Administration - instrumentation; Skin; staining; Studies; Transdermal Patch; Usability; vaccination; Vaccination - instrumentation; Vaccines; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Young Adult; United States > US; Microneedle, Human study; Usability; Influenza; Acceptability; Infection; Human; Viral disease; Vaccination; Human study; Microneedle

•First-in-humans study of microneedle patch usability and acceptability.•Users can correctly apply microneedle patches.•A snap-based device providing force feedback to users improved usability.•Microneedle patches increased intent to vaccinate from 44% to 65%.•64% of participants intending vaccinati...