Quantitative computed tomography–derived clusters: Redefining airway remodeling in asthmatic patients - Gupta, Sumit; Hartley, Ruth; Khan, Umair T.; Singapuri, Amisha; Hargadon, Beverly; Monteiro, William; Pavord, Ian D.; Sousa, Ana R.; Marshall, Richard P.; Subramanian, Deepak; Parr, David; Entwisle, James J.; et al. (Journal of allergy and clinical immunology, 2014)
Keywords: Adult; Aged; Airway Remodeling; Allergy and Immunology; Asthma; Asthma - diagnostic imaging; Asthma - pathology; Asthma - physiopathology; Asthma and Lower Airway Disease; Biological and medical sciences; Chronic obstructive pulmonary disease, asthma; Cluster Analysis; distal airway; Drug therapy; Female; fractal analysis; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Humans; Immunopathology; Lung - physiopathology; Male; Medical sciences; Methods; Middle Aged; Phenotype; phenotypes; Pneumology; Quality of life; quantitative imaging; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Software; Statistical analysis; Tomography; Tomography, X-Ray Computed - methods; Variables; quantitative imaging; ATS; RB1; fractal analysis; RV; LV; TLC; WA; HU; BSA; distal airway; Dsc; MLD E/I; VI−850/−950 E-I; cluster analysis; Pi10; WV; De; airway remodeling; ICC; VI−850 E-I; ROI; Asthma; CT; Dsce; phenotypes; VI; LA; FRC; Dav; Po20; Averaged fractal dimension; Hypothetical airways with outer airway perimeter of 20 mm; D e; D av; Computed tomography; Voxel index; VI −850/−950 E-I; Mean lung density expiratory/inspiratory ratio; VI−850 change on paired inspiratory and expiratory CT scan; Right upper lobe apical segmental bronchus; Intraclass correlation coefficient; Lumen area; D sc; Lumen volume; Wall volume; Functional residual capacity; Hypothetical airway with internal perimeter of 10 mm; Region of interest; Body surface area; Total lung capacity; Voxel index change of percent voxels between −950 and −850 HU on paired inspiratory and expiratory CT scan; American Thoracic Society; VI −850 E-I; Residual volume; Slope-corrected fractal dimension; Wall area; D sce; Hounsfield units; Most efficient cover fractal dimension; Slope-corrected most-efficient covering fractal dimension; Human; Lung disease; Immunopathology