Dynamin-Like Protein 1 Reduction Underlies Mitochondrial Morphology and Distribution Abnormalities in Fibroblasts from Sporadic Alzheimer's Disease Patients

• Published in: The American journal of pathology Vol. 173; no. 2; pp. 470 - 482
• Main Authors: Wang, Xinglong, Su, Bo, Fujioka, Hisashi, Zhu, Xiongwei
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Elsevier Inc 01.08.2008; ASIP; American Society for Investigative Pathology
• Subjects: Aged; Alzheimer Disease - pathology; Amyloid beta-Peptides - metabolism; Biological and medical sciences; Cells, Cultured; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Female; Fibroblasts - metabolism; Fibroblasts - pathology; GTP Phosphohydrolases - physiology; Humans; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Microscopy, Electron, Transmission; Microtubule-Associated Proteins - physiology; Mitochondria - ultrastructure; Mitochondrial Proteins - physiology; Neurology; Oxidative Stress; Pathology; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Regular; Human; Nervous system diseases; Sporadic; Alzheimer disease; Protein; Cerebral disorder; Anatomic pathology; Mitochondria; Reduction; Morphology; Central nervous system disease; Distribution; Dynamin; Degenerative disease; Anomaly; Fibroblast

Mitochondrial function relies heavily on its morphology and distribution, alterations of which have been increasingly implicated in neurodegenerative diseases, such as Alzheimer's disease (AD). In this study, we found abnormal mitochondrial distribution characterized by elongated mitochondria t...