A Novel Dimeric Inhibitor Targeting Beta2GPI in Beta2GPI/Antibody Complexes Implicated in Antiphospholipid Syndrome

• Published in: PloS one Vol. 5; no. 12; p. e15345
• Main Authors: Kolyada, Alexey, Lee, Chang-Jin, De Biasio, Alfredo, Beglova, Natalia
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 15.12.2010; Public Library of Science (PLoS)
• Subjects: Abortion; Abortion, Habitual - immunology; Animals; Antibodies; Antiphospholipid syndrome; Antiphospholipid Syndrome - immunology; Antiphospholipid Syndrome - therapy; Apolipoprotein E; Arthritis; Autoantibodies; Autoimmune diseases; Autoimmunity; BASIC BIOLOGICAL SCIENCES; beta 2-Glycoprotein I - antagonists & inhibitors; beta 2-Glycoprotein I - chemistry; Binding; Binding analysis; Binding sites; Biochemistry; Biology; Blood plasma; Cardiolipin; Cardiolipins - chemistry; Crystal structure; Crystallography, X-Ray - methods; Dimerization; Disulfides - chemistry; Female; Humans; Immunoglobulins; Inhibition; Inhibitors; Laboratories; Ligands; Lipids; Lipoprotein receptors; Lipoproteins; Medical schools; Medicine; Mice; Miscarriage; Monomers; Phospholipids; Pregnancy; Protein Binding; Protein Structure, Tertiary; Science & technology - other topics; Surface active agents; Thromboembolism; Thrombosis; United States > US; Massachusetts

β2GPI is a major antigen for autoantibodies associated with antiphospholipid syndrome (APS), an autoimmune disease characterized by thrombosis and recurrent pregnancy loss. Only the dimeric form of β2GPI generated by anti-β2GPI antibodies is pathologically important, in contrast to monomeric β2GPI w...