Successful Colistin Treatment of Multidrug-Resistant Pseudomonas aeruginosa Infection Using a Rapid Method for Determination of Colistin in Plasma: Usefulness of Therapeutic Drug Monitoring

• Published in: Biological & pharmaceutical bulletin Vol. 38; no. 9; pp. 1430 - 1433
• Main Authors: Yamada, Takehiro, Ishiguro, Nobuhisa, Oku, Kenji, Higuchi, Issei, Nakagawa, Ikuma, Noguchi, Atsushi, Yasuda, Shinsuke, Fukumoto, Tatsuya, Iwasaki, Sumio, Akizawa, Kouji, Furugen, Ayako, Yamaguchi, Hiroaki, Iseki, Ken
• Format: Journal Article
• Language: English
• Published: Japan The Pharmaceutical Society of Japan 01.09.2015; Pharmaceutical Society of Japan
• Subjects: Anti-Bacterial Agents - blood; Anti-Bacterial Agents - pharmacokinetics; Anti-Bacterial Agents - therapeutic use; Bacteremia - blood; Bacteremia - drug therapy; colistin; Colistin - blood; Colistin - pharmacokinetics; Colistin - therapeutic use; Drug Monitoring; Drug Resistance, Multiple, Bacterial; Female; Humans; Middle Aged; multidrug-resistant Pseudomonas aeruginosa; Pseudomonas aeruginosa; Pseudomonas Infections - blood; Pseudomonas Infections - drug therapy; Treatment Outcome

A 56-year-old woman with systemic lupus erythematosus had bacteremia due to multidrug-resistant Pseudomonas aeruginosa (MDRP). She was initially treated with imipenem–cilastatin, tobramycin, and aztreonam; however, MDRP was still detected intermittently in her plasma. Multidrug-susceptibility tests...