Reduction in Inflammatory Gene Expression in Skeletal Muscle from Roux-en-Y Gastric Bypass Patients Randomized to Omentectomy

• Published in: PloS one Vol. 6; no. 12; p. e28577
• Main Authors: Tamboli, Robyn A., Hajri, Tahar, Jiang, Aixiang, Marks-Shulman, Pamela A., Williams, D. Brandon, Clements, Ronald H., Melvin, Willie, Bowen, Benjamin P., Shyr, Yu, Abumrad, Naji N., Flynn, Charles Robb
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 16.12.2011; Public Library of Science (PLoS)
• Subjects: 60 APPLIED LIFE SCIENCES; Activating transcription factor 3; Adolescent; Adult; Analysis; Anthropometry; Biology; Biomarkers - blood; Cells (biology); Cluster Analysis; Complementarity-determining region 1; CX3CR1 protein; Data analysis; Data processing; DNA binding proteins; EGR-1 protein; extracellular matrix proteins; Female; FosB protein; Gastric Bypass; Gene expression; Gene Expression Profiling; Gene Expression Regulation; Genes; Genetic research; Glucose; Humans; Inflammation; Inflammation - blood; Inflammation - genetics; Information management; Insulin resistance; Interleukin 6; Interleukin 8; JunB protein; Kinases; Laparoscopy; Male; Medical research; Medicine; microarrays; Middle Aged; Monocyte chemoattractant protein 1; Muscle, Skeletal - metabolism; Muscle, Skeletal - pathology; Muscles; Myc protein; Nuclear receptors; Nucleoli; Obesity; Oligonucleotide Array Sequence Analysis; Omentum - metabolism; Omentum - pathology; Omentum - surgery; Orphan nuclear receptors; Patients; Physicians; Protein turnover; Randomization; Receptors; Reduction; Reproducibility of Results; Ribonucleic acid; RNA; Rodents; Satellite cells; Signal Transduction - genetics; Skeletal muscle; skeletal muscles; small nucleolar RNA; Surgery; Transcription (Genetics); Transcription factors; transcriptional control; Type 2 diabetes; Young Adult; United States > US; Nashville Tennessee

To examine the effects of Roux-en-Y gastric bypass (RYGB) surgery with and without laparoscopic removal of omental fat (omentectomy) on the temporal gene expression profiles of skeletal muscle. Previously reported were the whole-body metabolic effects of a randomized, single-blinded study in patient...