Deferoxamine promotes recovery of traumatic spinal cord injury by inhibiting ferroptosis
Ferroptosis is an iron-dependent novel cell death pathway. Deferoxamine, a ferroptosis inhibitor, has been reported to promote spinal cord injury repair. It has yet to be clarified whether ferroptosis inhibition represents the mechanism of action of Deferoxamine on spinal cord injury recovery. A rat...
Saved in:
Cover
Loading…
| Abstract | Ferroptosis is an iron-dependent novel cell death pathway. Deferoxamine, a ferroptosis inhibitor, has been reported to promote spinal cord injury repair. It has yet to be clarified whether ferroptosis inhibition represents the mechanism of action of Deferoxamine on spinal cord injury recovery. A rat model of Deferoxamine at thoracic 10 segment was established using a modified Allen's method. Ninety 8-week-old female Wistar rats were used. Rats in the Deferoxamine group were intraperitoneally injected with 100 mg/kg Deferoxamine 30 minutes before injury. Simultaneously, the Sham and Deferoxamine groups served as controls. Drug administration was conducted for 7 consecutive days. The results were as follows: (1) Electron microscopy revealed shrunken mitochondria in the spinal cord injury group. (2) The Basso, Beattie and Bresnahan locomotor rating score showed that recovery of the hindlimb was remarkably better in the Deferoxamine group than in the spinal cord injury group. (3) The iron concentration was lower in the Deferoxamine group than in the spinal cord injury group after injury. (4) Western blot assay revealed that, compared with the spinal cord injury group, GPX4, xCT, and glutathione expression was markedly increased in the Deferoxamine group. (5) Real-time polymerase chain reaction revealed that, compared with the Deferoxamine group, mRNA levels of ferroptosis-related genes Acyl-CoA synthetase family member 2 (ACSF2) and iron-responsive element-binding protein 2 (IREB2) were up-regulated in the Deferoxamine group. (6) Deferoxamine increased survival of neurons and inhibited gliosis. These findings confirm that Deferoxamine can repair spinal cord injury by inhibiting ferroptosis. Targeting ferroptosis is therefore a promising therapeutic approach for spinal cord injury. |
|---|---|
| AbstractList | Ferroptosis is an iron-dependent novel cell death pathway. Deferoxamine, a ferroptosis inhibitor, has been reported to promote spinal cord injury repair. It has yet to be clarified whether ferroptosis inhibition represents the mechanism of action of Deferoxamine on spinal cord injury recovery. A rat model of Deferoxamine at thoracic 10 segment was established using a modified Allen's method. Ninety 8-week-old female Wistar rats were used. Rats in the Deferoxamine group were intraperitoneally injected with 100 mg/kg Deferoxamine 30 minutes before injury. Simultaneously, the Sham and Deferoxamine groups served as controls. Drug administration was conducted for 7 consecutive days. The results were as follows: (1) Electron microscopy revealed shrunken mitochondria in the spinal cord injury group. (2) The Basso, Beattie and Bresnahan locomotor rating score showed that recovery of the hindlimb was remarkably better in the Deferoxamine group than in the spinal cord injury group. (3) The iron concentration was lower in the Deferoxamine group than in the spinal cord injury group after injury. (4) Western blot assay revealed that, compared with the spinal cord injury group, GPX4, xCT, and glutathione expression was markedly increased in the Deferoxamine group. (5) Real-time polymerase chain reaction revealed that, compared with the Deferoxamine group, mRNA levels of ferroptosis-related genes Acyl-CoA synthetase family member 2 (ACSF2) and iron-responsive element-binding protein 2 (IREB2) were up-regulated in the Deferoxamine group. (6) Deferoxamine increased survival of neurons and inhibited gliosis. These findings confirm that Deferoxamine can repair spinal cord injury by inhibiting ferroptosis. Targeting ferroptosis is therefore a promising therapeutic approach for spinal cord injury.Ferroptosis is an iron-dependent novel cell death pathway. Deferoxamine, a ferroptosis inhibitor, has been reported to promote spinal cord injury repair. It has yet to be clarified whether ferroptosis inhibition represents the mechanism of action of Deferoxamine on spinal cord injury recovery. A rat model of Deferoxamine at thoracic 10 segment was established using a modified Allen's method. Ninety 8-week-old female Wistar rats were used. Rats in the Deferoxamine group were intraperitoneally injected with 100 mg/kg Deferoxamine 30 minutes before injury. Simultaneously, the Sham and Deferoxamine groups served as controls. Drug administration was conducted for 7 consecutive days. The results were as follows: (1) Electron microscopy revealed shrunken mitochondria in the spinal cord injury group. (2) The Basso, Beattie and Bresnahan locomotor rating score showed that recovery of the hindlimb was remarkably better in the Deferoxamine group than in the spinal cord injury group. (3) The iron concentration was lower in the Deferoxamine group than in the spinal cord injury group after injury. (4) Western blot assay revealed that, compared with the spinal cord injury group, GPX4, xCT, and glutathione expression was markedly increased in the Deferoxamine group. (5) Real-time polymerase chain reaction revealed that, compared with the Deferoxamine group, mRNA levels of ferroptosis-related genes Acyl-CoA synthetase family member 2 (ACSF2) and iron-responsive element-binding protein 2 (IREB2) were up-regulated in the Deferoxamine group. (6) Deferoxamine increased survival of neurons and inhibited gliosis. These findings confirm that Deferoxamine can repair spinal cord injury by inhibiting ferroptosis. Targeting ferroptosis is therefore a promising therapeutic approach for spinal cord injury. Ferroptosis is an iron-dependent novel cell death pathway. Deferoxamine, a ferroptosis inhibitor, has been reported to promote spinal cord injury repair. It has yet to be clarified whether ferroptosis inhibition represents the mechanism of action of Deferoxamine on spinal cord injury recovery. A rat model of Deferoxamine at thoracic 10 segment was established using a modified Allen's method. Ninety 8-week-old female Wistar rats were used. Rats in the Deferoxamine group were intraperitoneally injected with 100 mg/kg Deferoxamine 30 minutes before injury. Simultaneously, the Sham and Deferoxamine groups served as controls. Drug administration was conducted for 7 consecutive days. The results were as follows: (1) Electron microscopy revealed shrunken mitochondria in the spinal cord injury group. (2) The Basso, Beattie and Bresnahan locomotor rating score showed that recovery of the hindlimb was remarkably better in the Deferoxamine group than in the spinal cord injury group. (3) The iron concentration was lower in the Deferoxamine group than in the spinal cord injury group after injury. (4) Western blot assay revealed that, compared with the spinal cord injury group, GPX4, xCT, and glutathione expression was markedly increased in the Deferoxamine group. (5) Real-time polymerase chain reaction revealed that, compared with the Deferoxamine group, mRNA levels of ferroptosis-related genes Acyl-CoA synthetase family member 2 (ACSF2) and iron-responsive element-binding protein 2 (IREB2) were up-regulated in the Deferoxamine group. (6) Deferoxamine increased survival of neurons and inhibited gliosis. These findings confirm that Deferoxamine can repair spinal cord injury by inhibiting ferroptosis. Targeting ferroptosis is therefore a promising therapeutic approach for spinal cord injury. R453%R392%R744; Ferroptosis is an iron-dependent novel cell death pathway. Deferoxamine, a ferroptosis inhibitor, has been reported to promote spinal cord injury repair. It has yet to be clarified whether ferroptosis inhibition represents the mechanism of action of Deferoxamine on spinal cord injury recovery. A rat model of Deferoxamine at thoracic 10 segment was established using a modified Allen's method. Ninety 8-week-old female Wistar rats were used. Rats in the Deferoxamine group were intraperitoneally injected with 100 mg/kg Deferoxamine 30 minutes before injury. Simultaneously, the Sham and Deferoxamine groups served as controls. Drug administration was conducted for 7 consecutive days. The results were as follows: (1) Electron microscopy revealed shrunken mitochondria in the spinal cord injury group. (2) The Basso, Beattie and Bresnahan locomotor rating score showed that recovery of the hindlimb was remarkably better in the Deferox-amine group than in the spinal cord injury group. (3) The iron concentration was lower in the Deferoxamine group than in the spinal cord injury group after injury. (4) Western blot assay revealed that, compared with the spinal cord injury group, GPX4, xCT, and glutathione expression was markedly increased in the Deferoxamine group. (5) Real-time polymerase chain reaction revealed that, compared with the Deferoxamine group, mRNA levels of ferroptosis-related genes Acyl-CoA synthetase family member 2 (ACSF2) and iron-responsive element-binding protein 2 (IREB2) were up-regulated in the Deferoxamine group. (6) Deferoxamine increased survival of neurons and inhibited gliosis. These findings confirm that Deferoxamine can repair spinal cord injury by inhibiting ferroptosis. Targeting ferroptosis is therefore a promising therapeutic approach for spinal cord injury. Ferroptosis is an iron-dependent novel cell death pathway. Deferoxamine, a ferroptosis inhibitor, has been reported to promote spinal cord injury repair. It has yet to be clarified whether ferroptosis inhibition represents the mechanism of action of Deferoxamine on spinal cord injury recovery. A rat model of Deferoxamine at thoracic 10 segment was established using a modified Allen’s method. Ninety 8-week-old female Wistar rats were used. Rats in the Deferoxamine group were intraperitoneally injected with 100 mg/kg Deferoxamine 30 minutes before injury. Simultaneously, the Sham and Deferoxamine groups served as controls. Drug administration was conducted for 7 consecutive days. The results were as follows: (1) Electron microscopy revealed shrunken mitochondria in the spinal cord injury group. (2) The Basso, Beattie and Bresnahan locomotor rating score showed that recovery of the hindlimb was remarkably better in the Deferoxamine group than in the spinal cord injury group. (3) The iron concentration was lower in the Deferoxamine group than in the spinal cord injury group after injury. (4) Western blot assay revealed that, compared with the spinal cord injury group, GPX4, xCT, and glutathione expression was markedly increased in the Deferoxamine group. (5) Real-time polymerase chain reaction revealed that, compared with the Deferoxamine group, mRNA levels of ferroptosis-related genes Acyl-CoA synthetase family member 2 ( ACSF2 ) and iron-responsive element-binding protein 2 ( IREB2 ) were up-regulated in the Deferoxamine group. (6) Deferoxamine increased survival of neurons and inhibited gliosis. These findings confirm that Deferoxamine can repair spinal cord injury by inhibiting ferroptosis. Targeting ferroptosis is therefore a promising therapeutic approach for spinal cord injury. |
| Audience | Academic |
| Author | Hu, Yong Feng, Shi-Qing Wang, Xu Fu, Xuan-Hao Yao, Xue Kong, Xiao-Hong Sun, Chao Li, Bo Li, Wen-Xiang Hao, Jian Zhang, Yan Duan, Hui-Quan Fan, Bao-You Zhao, Chen-Xi Liu, Chang |
| AuthorAffiliation | Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, China;State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, China;International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin, China%Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, China;International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin, China%Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, China;Department of Orthopedics, Nankai Hospital, Tianjin, China%Department of Orthopedic and Traumatology, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China%School of Medicine, Nankai University, Tianjin, China%Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, China;International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin, China;Tianjin Neurological Institute, Key Laboratory o |
| AuthorAffiliation_xml | – name: Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, China;State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, China;International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin, China%Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, China;International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin, China%Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, China;Department of Orthopedics, Nankai Hospital, Tianjin, China%Department of Orthopedic and Traumatology, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China%School of Medicine, Nankai University, Tianjin, China%Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, China;International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin, China;Tianjin Neurological Institute, Key Laboratory of Post-Neuroinjury Neuro-repair and Regeneration in Central Nervous System, Ministry of Education and Tianjin City, Tianjin, China – name: 3 International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin, China – name: 7 Tianjin Neurological Institute, Key Laboratory of Post-Neuroinjury Neuro-repair and Regeneration in Central Nervous System, Ministry of Education and Tianjin City, Tianjin, China – name: 6 School of Medicine, Nankai University, Tianjin, China – name: 2 State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, China – name: 1 Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, China – name: 5 Department of Orthopedic and Traumatology, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China – name: 4 Department of Orthopedics, Nankai Hospital, Tianjin, China |
| Author_xml | – sequence: 1 givenname: Xue surname: Yao fullname: Yao, Xue organization: Department of Orthopedics, Tianjin Medical University General Hospital; State Key Laboratory of Medicinal Chemical Biology, Nankai University; International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin – sequence: 2 givenname: Yan surname: Zhang fullname: Zhang, Yan organization: Department of Orthopedics, Tianjin Medical University General Hospital; International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin – sequence: 3 givenname: Jian surname: Hao fullname: Hao, Jian organization: Department of Orthopedics, Tianjin Medical University General Hospital; Department of Orthopedics, Nankai Hospital, Tianjin – sequence: 4 givenname: Hui-Quan surname: Duan fullname: Duan, Hui-Quan organization: Department of Orthopedics, Tianjin Medical University General Hospital; International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin – sequence: 5 givenname: Chen-Xi surname: Zhao fullname: Zhao, Chen-Xi organization: Department of Orthopedics, Tianjin Medical University General Hospital; International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin – sequence: 6 givenname: Chao surname: Sun fullname: Sun, Chao organization: Department of Orthopedics, Tianjin Medical University General Hospital; International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin – sequence: 7 givenname: Bo surname: Li fullname: Li, Bo organization: Department of Orthopedics, Tianjin Medical University General Hospital; International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin – sequence: 8 givenname: Bao-You surname: Fan fullname: Fan, Bao-You organization: Department of Orthopedics, Tianjin Medical University General Hospital; International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin – sequence: 9 givenname: Xu surname: Wang fullname: Wang, Xu organization: Department of Orthopedics, Tianjin Medical University General Hospital; International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin – sequence: 10 givenname: Wen-Xiang surname: Li fullname: Li, Wen-Xiang organization: Department of Orthopedics, Tianjin Medical University General Hospital; International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin – sequence: 11 givenname: Xuan-Hao surname: Fu fullname: Fu, Xuan-Hao organization: Department of Orthopedics, Tianjin Medical University General Hospital; International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin – sequence: 12 givenname: Yong surname: Hu fullname: Hu, Yong organization: Department of Orthopedic and Traumatology, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region – sequence: 13 givenname: Chang surname: Liu fullname: Liu, Chang organization: School of Medicine, Nankai University, Tianjin – sequence: 14 givenname: Xiao-Hong surname: Kong fullname: Kong, Xiao-Hong organization: School of Medicine, Nankai University, Tianjin – sequence: 15 givenname: Shi-Qing surname: Feng fullname: Feng, Shi-Qing organization: Department of Orthopedics, Tianjin Medical University General Hospital; International Science and Technology Cooperation Base of Spinal Cord Injury; Tianjin Neurological Institute, Key Laboratory of Post-Neuroinjury Neuro-repair and Regeneration in Central Nervous System, Ministry of Education and Tianjin City, Tianjin |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30539824$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kktv1DAUhSNURB-wZ4UisUFCGfyIHXuD1JZXpUpsQGJnOc5N6mliD3bSMv31OMxM6VQIZRHr3nM-X1-d4-zAeQdZ9hKjRYkRfYd5RQtGq3JBSlYK9CQ7wqLiRSWZOEjnXfswO45xiRATktBn2SFFjEpByqPsxwdoIfhferAO8lXwgx8h5gGMv4Gwzn2bj0FPgx6tyePKOt3nxocmt245pX69TqcrW9vRui5PqOBXo482Ps-etrqP8GL7P8m-f_r47fxLcfn188X56WVhKix0URNoK0p42WCoZUlFgyuqgdJKV7VujUllhgBzxgGDBCEazgxqJMWSS1PTk-xiw228XqpVsIMOa-W1VX8KPnRKhzR8D6qVwFrDiJCAysqwuqYcRCU1AQFEo8R6v2GtpnqAxoBLb-_3oPsdZ69U528Up7TkiCfA2w3gVrtWu04t_RTSyqK66-LyLq6XCgjCElFEyqR-s70u-J8TxFENNhroe-3AT1ERzBhmlaQ0SV8_kt6TCRUEEy4o-6vqdHquda1PU5oZqk4ZZzIB8axa_EOVvgYGa1LAWpvqe4ZXD9dyv49dipKAbwQm-BgDtMrYMSXGz1uyvcJIzXFVcx7VnEe1iWsyokfGHfs_lrPtin0_QojX_XQLQaW5rp2_3fMVD3yJQdQu6_Q3FDkAiw |
| CitedBy_id | crossref_primary_10_1007_s12035_023_03814_w crossref_primary_10_1142_S0192415X24500770 crossref_primary_10_3390_ph18020271 crossref_primary_10_1016_j_intimp_2024_112521 crossref_primary_10_3389_fcvm_2022_964034 crossref_primary_10_1007_s12035_023_03501_w crossref_primary_10_1073_pnas_2220300120 crossref_primary_10_1016_j_isci_2023_107647 crossref_primary_10_3892_ijmm_2023_5256 crossref_primary_10_1089_ars_2021_0120 crossref_primary_10_1007_s12033_024_01139_0 crossref_primary_10_4103_1673_5374_350209 crossref_primary_10_1016_j_ejphar_2025_177349 crossref_primary_10_3390_antiox12030731 crossref_primary_10_1111_cns_14524 crossref_primary_10_3389_fmolb_2022_902607 crossref_primary_10_1016_j_jchemneu_2020_101807 crossref_primary_10_1016_j_freeradbiomed_2025_02_027 crossref_primary_10_1016_j_phymed_2024_155380 crossref_primary_10_1155_2022_7906218 crossref_primary_10_3389_fimmu_2024_1330678 crossref_primary_10_4103_1673_5374_266060 crossref_primary_10_3389_fmolb_2022_890766 crossref_primary_10_1002_adtp_202400165 crossref_primary_10_1186_s40001_023_01264_7 crossref_primary_10_3390_metabo12080745 crossref_primary_10_3389_fneur_2023_1280908 crossref_primary_10_1021_acs_jmedchem_4c00403 crossref_primary_10_1155_2022_3112388 crossref_primary_10_1155_2022_7410865 crossref_primary_10_1016_j_brainresbull_2022_11_010 crossref_primary_10_1016_j_biopha_2024_116734 crossref_primary_10_1016_j_micpath_2024_107014 crossref_primary_10_3389_fncel_2024_1475934 crossref_primary_10_3389_fcell_2021_705786 crossref_primary_10_1016_j_lfs_2022_121272 crossref_primary_10_1093_jnen_nlae094 crossref_primary_10_1016_j_bioactmat_2024_05_015 crossref_primary_10_1016_j_wneu_2021_11_085 crossref_primary_10_3389_fcell_2021_789948 crossref_primary_10_3390_ijms26020723 crossref_primary_10_1007_s12015_022_10327_x crossref_primary_10_3389_fonc_2022_930654 crossref_primary_10_1016_j_msard_2025_106378 crossref_primary_10_1016_j_brainresbull_2023_110753 crossref_primary_10_1186_s13148_024_01639_5 crossref_primary_10_1089_ars_2021_0218 crossref_primary_10_1007_s11010_021_04327_7 crossref_primary_10_1002_ar_25130 crossref_primary_10_1038_s41420_024_02181_2 crossref_primary_10_3389_fonc_2022_798304 crossref_primary_10_3892_ol_2024_14697 crossref_primary_10_1038_s41375_022_01614_0 crossref_primary_10_1016_j_intimp_2022_109257 crossref_primary_10_3389_fcell_2023_1297024 crossref_primary_10_1016_j_yexmp_2020_104570 crossref_primary_10_1021_acsami_4c21589 crossref_primary_10_4103_1673_5374_371378 crossref_primary_10_4103_1673_5374_371377 crossref_primary_10_1038_s41392_024_01969_z crossref_primary_10_1155_2022_6520789 crossref_primary_10_3389_fonc_2021_579286 crossref_primary_10_2174_0113895575273164231130070920 crossref_primary_10_3389_fcell_2021_661317 crossref_primary_10_4103_1673_5374_250633 crossref_primary_10_1002_jsp2_1344 crossref_primary_10_1016_j_prostaglandins_2022_106671 crossref_primary_10_1016_j_ejmech_2025_117516 crossref_primary_10_1007_s00210_020_01932_z crossref_primary_10_1038_s41420_023_01613_9 crossref_primary_10_4103_1673_5374_301487 crossref_primary_10_1016_j_jes_2024_05_003 crossref_primary_10_1016_j_ejmech_2022_115015 crossref_primary_10_1038_s41598_025_86170_0 crossref_primary_10_1016_j_nantod_2022_101625 crossref_primary_10_14336_AD_2023_0509 crossref_primary_10_1007_s12035_023_03423_7 crossref_primary_10_3892_mmr_2023_13123 crossref_primary_10_1016_j_bbrc_2023_09_088 crossref_primary_10_1007_s11064_023_03993_x crossref_primary_10_4103_1673_5374_270418 crossref_primary_10_1007_s00109_023_02346_z crossref_primary_10_1016_j_biopha_2024_116777 crossref_primary_10_1016_j_cej_2024_157285 crossref_primary_10_14245_ns_2448038_019 crossref_primary_10_3389_fnins_2022_1032140 crossref_primary_10_1152_ajpregu_00117_2023 crossref_primary_10_1007_s12031_021_01890_y crossref_primary_10_1016_j_wneu_2023_06_043 crossref_primary_10_2147_IJGM_S460164 crossref_primary_10_3390_molecules28062636 crossref_primary_10_1016_j_lfs_2020_118905 crossref_primary_10_3390_cells9102259 crossref_primary_10_1016_j_lfs_2020_117351 crossref_primary_10_1007_s12035_023_03543_0 crossref_primary_10_1111_cns_13657 crossref_primary_10_1016_j_ajpath_2019_09_012 crossref_primary_10_3389_fonc_2022_746030 crossref_primary_10_3892_or_2024_8851 crossref_primary_10_37212_jcnos_1358141 crossref_primary_10_2174_1389201024666230823091144 crossref_primary_10_3389_fgene_2021_708699 crossref_primary_10_1111_imr_13280 crossref_primary_10_1007_s12035_023_03287_x crossref_primary_10_3390_cells14060461 crossref_primary_10_1097_WNR_0000000000001996 crossref_primary_10_1016_j_brainres_2023_148497 crossref_primary_10_1186_s12915_025_02154_6 crossref_primary_10_4103_1673_5374_274344 crossref_primary_10_1089_ars_2022_0101 crossref_primary_10_18632_aging_204009 crossref_primary_10_3390_jcm12062125 crossref_primary_10_1152_ajprenal_00016_2021 crossref_primary_10_1016_j_ijbiomac_2025_140453 crossref_primary_10_1007_s12035_022_02935_y crossref_primary_10_1016_j_freeradbiomed_2024_11_052 crossref_primary_10_1007_s00401_024_02758_2 crossref_primary_10_1155_2020_6375938 crossref_primary_10_1016_j_ccr_2023_215024 crossref_primary_10_3389_fcell_2021_644901 crossref_primary_10_3390_ijms242417279 crossref_primary_10_1002_2211_5463_13203 crossref_primary_10_2139_ssrn_4165354 crossref_primary_10_1038_s41413_022_00199_9 crossref_primary_10_1039_D1FO01036K crossref_primary_10_1155_2022_4295208 crossref_primary_10_3389_fphar_2022_791376 crossref_primary_10_1016_j_biopha_2020_110108 crossref_primary_10_1016_j_ejmech_2024_117192 crossref_primary_10_1016_j_neuroscience_2025_02_030 crossref_primary_10_4103_1673_5374_293157 crossref_primary_10_1016_j_bcp_2024_116257 crossref_primary_10_3389_fnins_2023_1136143 crossref_primary_10_1016_j_compositesb_2022_110242 crossref_primary_10_1016_j_intimp_2021_108158 crossref_primary_10_1016_j_jinorgbio_2023_112299 crossref_primary_10_3389_fmed_2022_1034692 crossref_primary_10_1016_j_neuint_2023_105554 crossref_primary_10_3390_molecules29092050 crossref_primary_10_4103_1673_5374_350187 crossref_primary_10_3389_fphar_2024_1407335 crossref_primary_10_1016_j_bbrc_2024_150853 crossref_primary_10_1016_j_amjms_2023_04_024 crossref_primary_10_1039_D2BM00678B crossref_primary_10_1016_j_bbamcr_2020_118928 crossref_primary_10_1016_j_neuroscience_2023_05_029 crossref_primary_10_1016_j_wneu_2022_08_121 crossref_primary_10_1038_s41418_021_00907_8 crossref_primary_10_3389_fnins_2024_1254600 crossref_primary_10_1155_2022_6833867 crossref_primary_10_1038_s41419_023_05969_9 crossref_primary_10_1016_j_bioorg_2024_107331 crossref_primary_10_1007_s12035_024_04188_3 crossref_primary_10_1016_j_intimp_2024_113542 crossref_primary_10_3389_fphys_2021_680544 crossref_primary_10_1016_j_freeradbiomed_2024_05_014 crossref_primary_10_1111_bph_15950 crossref_primary_10_1016_j_tem_2021_04_010 crossref_primary_10_1155_2022_2075638 crossref_primary_10_1016_j_jot_2020_02_011 crossref_primary_10_3389_fcell_2020_00594 crossref_primary_10_3389_fphar_2025_1570069 crossref_primary_10_1007_s12035_023_03525_2 crossref_primary_10_3390_cancers16183131 crossref_primary_10_1016_j_bbrc_2019_04_137 crossref_primary_10_3389_fcell_2022_849854 crossref_primary_10_3389_fmolb_2022_1019447 crossref_primary_10_3390_inorganics12010026 crossref_primary_10_1016_j_brainresbull_2021_04_023 crossref_primary_10_1155_2022_6041612 crossref_primary_10_31083_j_jin2303065 crossref_primary_10_1186_s13018_023_04195_5 crossref_primary_10_1021_acsnano_9b05821 crossref_primary_10_7555_JBR_37_20230224 crossref_primary_10_1016_j_tips_2023_06_005 crossref_primary_10_1080_09553002_2020_1708993 crossref_primary_10_1016_j_molmet_2022_101502 crossref_primary_10_1021_acschembio_4c00229 crossref_primary_10_1002_jemt_24335 crossref_primary_10_1038_s41419_024_06807_2 crossref_primary_10_1007_s10863_024_10034_x crossref_primary_10_1016_j_ijbiomac_2024_133484 crossref_primary_10_12680_balneo_2022_502 crossref_primary_10_1038_s41420_022_01297_7 crossref_primary_10_1177_15330338241272036 crossref_primary_10_1016_j_chembiol_2020_03_014 crossref_primary_10_1681_ASN_2019060595 crossref_primary_10_3390_cells12010090 crossref_primary_10_1016_j_ejphar_2024_176710 crossref_primary_10_1186_s12974_022_02602_y crossref_primary_10_3390_life13010009 crossref_primary_10_1016_j_bone_2024_117384 crossref_primary_10_1016_j_arr_2024_102477 crossref_primary_10_1016_j_freeradbiomed_2024_06_020 crossref_primary_10_1155_2021_9916328 crossref_primary_10_1016_j_ntm_2023_100005 crossref_primary_10_1038_s41598_025_86991_z crossref_primary_10_1016_j_intimp_2024_113227 crossref_primary_10_3389_fneur_2022_926780 crossref_primary_10_1186_s12951_023_01896_1 crossref_primary_10_3389_fncel_2023_1228968 crossref_primary_10_1111_petr_14164 crossref_primary_10_1186_s12974_023_02848_0 crossref_primary_10_3390_metabo12090874 crossref_primary_10_1002_jcb_30614 crossref_primary_10_1111_jnc_14790 crossref_primary_10_1177_09603271211059497 |
| Cites_doi | 10.1073/pnas.1611282113 10.1016/j.expneurol.2012.05.014 10.1111/ene.13208 10.1038/s41598-017-01402-2 10.1006/exnr.2001.7628 10.1371/journal.pone.0157602 10.1016/j.brainres.2008.12.030 10.1006/exnr.2002.7998 10.3109/10715761003742993 10.1177/0963689718755778 10.1016/j.freeradbiomed.2017.07.010 10.1006/exnr.2001.7629 10.1172/jci.insight.90777 10.1089/neu.1995.12.1 10.1194/jlr.M700378-JLR200 10.1007/82_2016_508 10.1016/j.cell.2012.03.042 10.1074/jbc.M115.680090 10.1038/nrn3820 10.4103/1673-5374.208591 10.1523/JNEUROSCI.17-14-05395.1997 10.1016/S0967-2109(03)00077-2 10.1016/j.neulet.2007.05.058 10.1016/j.neuint.2017.01.004 10.1161/STROKEAHA.116.015609 10.1016/j.neuroscience.2014.02.007 10.3171/jns.1976.44.4.0429 10.1038/sc.2012.42 10.1006/meth.2001.1262 10.4103/1673-5374.147952 10.1016/j.cell.2017.09.021 10.1056/NEJMra1516539 10.1186/s13024-016-0081-8 10.1016/j.nbd.2016.05.011 10.1002/cne.10806 10.1016/S0022-2275(20)32182-9 10.2147/JN.S89682 10.1016/j.tips.2017.02.005 10.1097/00007632-200007150-00022 |
| ClassificationCodes | R453%R392%R744 |
| ContentType | Journal Article |
| Copyright | COPYRIGHT 2019 Medknow Publications and Media Pvt. Ltd. 2019. This article is published under (http://creativecommons.org/licenses/by-nc-sa/3.0/) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Copyright © Wanfang Data Co. Ltd. All Rights Reserved. Copyright: © Neural Regeneration Research 2019 |
| Copyright_xml | – notice: COPYRIGHT 2019 Medknow Publications and Media Pvt. Ltd. – notice: 2019. This article is published under (http://creativecommons.org/licenses/by-nc-sa/3.0/) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: Copyright © Wanfang Data Co. Ltd. All Rights Reserved. – notice: Copyright: © Neural Regeneration Research 2019 |
| DBID | AAYXX CITATION NPM 3V. 7X7 7XB 88G 8FI 8FJ 8FK ABUWG AFKRA AZQEC BENPR CCPQU DWQXO FYUFA GHDGH GNUQQ K9. M0S M2M PHGZM PHGZT PIMPY PKEHL PQEST PQQKQ PQUKI PRINS PSYQQ Q9U 7X8 2B. 4A8 92I 93N PSX TCJ 5PM DOA |
| DOI | 10.4103/1673-5374.245480 |
| DatabaseName | CrossRef PubMed ProQuest Central (Corporate) Health & Medical Collection ProQuest Central (purchase pre-March 2016) Psychology Database (Alumni) Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials ProQuest Central ProQuest One ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student ProQuest Health & Medical Complete (Alumni) ProQuest Health & Medical Collection Psychology Database ProQuest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest One Academic Middle East (New) ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest One Psychology ProQuest Central Basic MEDLINE - Academic Wanfang Data Journals - Hong Kong WANFANG Data Centre Wanfang Data Journals 万方数据期刊 - 香港版 China Online Journals (COJ) China Online Journals (COJ) PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef PubMed Publicly Available Content Database ProQuest One Psychology ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest Central China ProQuest Central Health Research Premium Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea ProQuest Central (New) ProQuest Central Basic ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Psychology Journals (Alumni) ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Psychology Journals ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic PubMed Publicly Available Content Database |
| Database_xml | – sequence: 1 dbid: DOA name: Directory of Open Access Journals (DOAJ) url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Anatomy & Physiology |
| EISSN | 1876-7958 |
| EndPage | 541 |
| ExternalDocumentID | oai_doaj_org_article_f9e5fc5289e047c5bb36e879a2e8e2a0 PMC6334606 zgsjzsyj_e201903024 A565921515 30539824 10_4103_1673_5374_245480 10.4103/1673-5374.245480_532_Deferoxa |
| Genre | Journal Article |
| GeographicLocations | United States--US China |
| GeographicLocations_xml | – name: China – name: United States--US |
| GrantInformation_xml | – fundername: This study was supported by the National Natural Science Foundation of China, No. 81672171; 81330042; 81620108018; 81772342; the State Key Laboratory of Medicinal Chemical Biology; China, No. 2017027 |
| GroupedDBID | --- -SE -S~ 0R~ 53G 5RS 5VR 5VS 7X7 8FI 8FJ 92F 92I ABUWG ACGFS ADBBV ADJBI AENEX AFKRA AFUIB ALIPV ALMA_UNASSIGNED_HOLDINGS AZQEC BAWUL BENPR CAJEE CCEZO CCPQU CHBEP CIEJG CS3 CW9 DIK DU5 DWQXO FA0 FDB FYUFA GNUQQ GROUPED_DOAJ GX1 H13 HMCUK HYE IAO IEA IHR ITC KQ8 M2M M48 M5~ NQ- O9- OK1 OVD PGMZT PHGZM PHGZT PIMPY PSYQQ Q-- RMW RPM TCJ TEORI TGQ U1G U5O UKHRP W3E WFFXF --K 123 1B1 4.4 AAEDT AAKAS AALRI AAXUO AAYXX ABWVN ACRPL ADMUD ADNMO ADRAZ ADZCM CITATION EBS EJD EMOBN EO8 HZ~ IHE IPNFZ M41 RIG ROL RPZ NPM PMFND 3V. 7XB 8FK K9. PKEHL PQEST PQQKQ PQUKI PRINS Q9U 7X8 2B. 4A8 93N PSX 5PM PUEGO |
| ID | FETCH-LOGICAL-c718a-b2ef73264d1eb9438d173ae337a7bafcc1eb50e1656e1e9e88d65c0d931969cb3 |
| IEDL.DBID | M48 |
| ISSN | 1673-5374 |
| IngestDate | Wed Aug 27 01:25:25 EDT 2025 Thu Aug 21 18:24:02 EDT 2025 Thu May 29 04:06:14 EDT 2025 Fri Jul 11 08:53:56 EDT 2025 Fri Jul 25 03:42:58 EDT 2025 Tue Jun 17 21:05:47 EDT 2025 Tue Jun 10 20:25:44 EDT 2025 Tue Aug 05 11:42:06 EDT 2025 Tue Jul 01 03:20:18 EDT 2025 Thu Apr 24 22:54:29 EDT 2025 Tue Jun 17 22:46:11 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 3 |
| Keywords | spinal cord injury treatment deferoxamine ferroptosis neural regeneration GPX4 secondary injury xCT iron nerve regeneration astrogliosis lipid peroxidation |
| Language | English |
| License | http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c718a-b2ef73264d1eb9438d173ae337a7bafcc1eb50e1656e1e9e88d65c0d931969cb3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Author contributions: Study design and concept: SQF, XY, XHK and JH; experiment implementation: YZ, HQD, CS and CXZ; provision of critical reagents and scientific input: CL and BL; rat management: CXZ, XW, WXL, XHF and BYF; data analysis and paper preparation: YZ, JH and XY. All authors approved the final version of the paper. |
| ORCID | 0000-0001-9437-7674 |
| OpenAccessLink | https://www.proquest.com/docview/2382126835?pq-origsite=%requestingapplication% |
| PMID | 30539824 |
| PQID | 2382126835 |
| PQPubID | 4671210 |
| PageCount | 10 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_f9e5fc5289e047c5bb36e879a2e8e2a0 pubmedcentral_primary_oai_pubmedcentral_nih_gov_6334606 wanfang_journals_zgsjzsyj_e201903024 proquest_miscellaneous_2155157933 proquest_journals_2382126835 gale_infotracmisc_A565921515 gale_infotracacademiconefile_A565921515 pubmed_primary_30539824 crossref_citationtrail_10_4103_1673_5374_245480 crossref_primary_10_4103_1673_5374_245480 wolterskluwer_medknow_10_4103_1673-5374_245480_532_Deferoxa |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 20190301 |
| PublicationDateYYYYMMDD | 2019-03-01 |
| PublicationDate_xml | – month: 3 year: 2019 text: 20190301 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | India |
| PublicationPlace_xml | – name: India – name: Mumbai |
| PublicationTitle | Neural regeneration research |
| PublicationTitleAlternate | Neural Regen Res |
| PublicationTitle_FL | Neural Regeneration Research |
| PublicationYear | 2019 |
| Publisher | Wolters Kluwer India Pvt. Ltd Medknow Publications and Media Pvt. Ltd Medknow Publications & Media Pvt. Ltd International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin, China%Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, China Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, China Tianjin Neurological Institute, Key Laboratory of Post-Neuroinjury Neuro-repair and Regeneration in Central Nervous System, Ministry of Education and Tianjin City, Tianjin, China State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, China International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin, China Department of Orthopedics, Nankai Hospital, Tianjin, China%Department of Orthopedic and Traumatology, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China%School of Medicine, Nankai University, Tianjin, China%Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, China Medknow Publications & Media Pvt Ltd Wolters Kluwer Medknow Publications |
| Publisher_xml | – name: Wolters Kluwer India Pvt. Ltd – name: Medknow Publications and Media Pvt. Ltd – name: Medknow Publications & Media Pvt. Ltd – name: International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin, China%Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, China – name: State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, China – name: Department of Orthopedics, Nankai Hospital, Tianjin, China%Department of Orthopedic and Traumatology, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China%School of Medicine, Nankai University, Tianjin, China%Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, China – name: Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, China – name: Tianjin Neurological Institute, Key Laboratory of Post-Neuroinjury Neuro-repair and Regeneration in Central Nervous System, Ministry of Education and Tianjin City, Tianjin, China – name: International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin, China – name: Medknow Publications & Media Pvt Ltd – name: Wolters Kluwer Medknow Publications |
| References | key-10.4103/1673-5374.245480-9 key-10.4103/1673-5374.245480-7 key-10.4103/1673-5374.245480-8 key-10.4103/1673-5374.245480-1 key-10.4103/1673-5374.245480-41 key-10.4103/1673-5374.245480-2 key-10.4103/1673-5374.245480-20 key-10.4103/1673-5374.245480-21 key-10.4103/1673-5374.245480-22 key-10.4103/1673-5374.245480-5 key-10.4103/1673-5374.245480-6 key-10.4103/1673-5374.245480-3 key-10.4103/1673-5374.245480-4 key-10.4103/1673-5374.245480-40 key-10.4103/1673-5374.245480-16 key-10.4103/1673-5374.245480-38 key-10.4103/1673-5374.245480-17 key-10.4103/1673-5374.245480-39 key-10.4103/1673-5374.245480-18 key-10.4103/1673-5374.245480-19 key-10.4103/1673-5374.245480-12 key-10.4103/1673-5374.245480-34 key-10.4103/1673-5374.245480-13 key-10.4103/1673-5374.245480-35 key-10.4103/1673-5374.245480-14 key-10.4103/1673-5374.245480-36 key-10.4103/1673-5374.245480-15 key-10.4103/1673-5374.245480-37 key-10.4103/1673-5374.245480-30 key-10.4103/1673-5374.245480-31 key-10.4103/1673-5374.245480-10 key-10.4103/1673-5374.245480-32 key-10.4103/1673-5374.245480-11 key-10.4103/1673-5374.245480-33 key-10.4103/1673-5374.245480-27 key-10.4103/1673-5374.245480-28 key-10.4103/1673-5374.245480-29 key-10.4103/1673-5374.245480-23 key-10.4103/1673-5374.245480-24 key-10.4103/1673-5374.245480-25 key-10.4103/1673-5374.245480-26 |
| References_xml | – ident: key-10.4103/1673-5374.245480-18 doi: 10.1073/pnas.1611282113 – ident: key-10.4103/1673-5374.245480-6 doi: 10.1016/j.expneurol.2012.05.014 – ident: key-10.4103/1673-5374.245480-28 doi: 10.1111/ene.13208 – ident: key-10.4103/1673-5374.245480-27 doi: 10.1038/s41598-017-01402-2 – ident: key-10.4103/1673-5374.245480-15 doi: 10.1006/exnr.2001.7628 – ident: key-10.4103/1673-5374.245480-29 doi: 10.1371/journal.pone.0157602 – ident: key-10.4103/1673-5374.245480-40 doi: 10.1016/j.brainres.2008.12.030 – ident: key-10.4103/1673-5374.245480-31 doi: 10.1006/exnr.2002.7998 – ident: key-10.4103/1673-5374.245480-32 doi: 10.3109/10715761003742993 – ident: key-10.4103/1673-5374.245480-10 doi: 10.1177/0963689718755778 – ident: key-10.4103/1673-5374.245480-7 doi: 10.1016/j.freeradbiomed.2017.07.010 – ident: key-10.4103/1673-5374.245480-14 doi: 10.1006/exnr.2001.7629 – ident: key-10.4103/1673-5374.245480-22 doi: 10.1172/jci.insight.90777 – ident: key-10.4103/1673-5374.245480-2 doi: 10.1089/neu.1995.12.1 – ident: key-10.4103/1673-5374.245480-37 doi: 10.1194/jlr.M700378-JLR200 – ident: key-10.4103/1673-5374.245480-20 doi: 10.1007/82_2016_508 – ident: key-10.4103/1673-5374.245480-8 doi: 10.1016/j.cell.2012.03.042 – ident: key-10.4103/1673-5374.245480-5 doi: 10.1074/jbc.M115.680090 – ident: key-10.4103/1673-5374.245480-3 doi: 10.1038/nrn3820 – ident: key-10.4103/1673-5374.245480-17 doi: 10.4103/1673-5374.208591 – ident: key-10.4103/1673-5374.245480-24 doi: 10.1523/JNEUROSCI.17-14-05395.1997 – ident: key-10.4103/1673-5374.245480-39 – ident: key-10.4103/1673-5374.245480-4 doi: 10.1016/S0967-2109(03)00077-2 – ident: key-10.4103/1673-5374.245480-12 doi: 10.1016/j.neulet.2007.05.058 – ident: key-10.4103/1673-5374.245480-16 doi: 10.1016/j.neuint.2017.01.004 – ident: key-10.4103/1673-5374.245480-41 doi: 10.1161/STROKEAHA.116.015609 – ident: key-10.4103/1673-5374.245480-36 doi: 10.1016/j.neuroscience.2014.02.007 – ident: key-10.4103/1673-5374.245480-21 doi: 10.3171/jns.1976.44.4.0429 – ident: key-10.4103/1673-5374.245480-23 – ident: key-10.4103/1673-5374.245480-38 doi: 10.1038/sc.2012.42 – ident: key-10.4103/1673-5374.245480-25 doi: 10.1006/meth.2001.1262 – ident: key-10.4103/1673-5374.245480-35 doi: 10.4103/1673-5374.147952 – ident: key-10.4103/1673-5374.245480-34 doi: 10.1016/j.cell.2017.09.021 – ident: key-10.4103/1673-5374.245480-33 doi: 10.1056/NEJMra1516539 – ident: key-10.4103/1673-5374.245480-11 doi: 10.1186/s13024-016-0081-8 – ident: key-10.4103/1673-5374.245480-9 doi: 10.1016/j.nbd.2016.05.011 – ident: key-10.4103/1673-5374.245480-30 doi: 10.1002/cne.10806 – ident: key-10.4103/1673-5374.245480-13 doi: 10.1016/S0022-2275(20)32182-9 – ident: key-10.4103/1673-5374.245480-19 doi: 10.2147/JN.S89682 – ident: key-10.4103/1673-5374.245480-1 doi: 10.1016/j.tips.2017.02.005 – ident: key-10.4103/1673-5374.245480-26 doi: 10.1097/00007632-200007150-00022 |
| SSID | ssj0058923 |
| Score | 2.5564625 |
| Snippet | Ferroptosis is an iron-dependent novel cell death pathway. Deferoxamine, a ferroptosis inhibitor, has been reported to promote spinal cord injury repair. It... R453%R392%R744; Ferroptosis is an iron-dependent novel cell death pathway. Deferoxamine, a ferroptosis inhibitor, has been reported to promote spinal cord... |
| SourceID | doaj pubmedcentral wanfang proquest gale pubmed crossref wolterskluwer |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 532 |
| SubjectTerms | Animals Apoptosis Biochemistry Care and treatment Cell death Contusions Deferoxamine FDA approval Ferroptosis Lipids Medical research nerve regeneration; iron; spinal cord injury; secondary injury; ferroptosis; deferoxamine; GPX4; xCT; treatment; astrogliosis; lipid peroxidation; neural regeneration Novels Physiological aspects Spinal cord injuries |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELZQJSQuCCiPQEFGqkAcwiaxndjitDyqCglOVNqbZTtOu1s2WTW7Kttfz4yTDRuQ4MIt8iOxPWPPN_H4MyHHJTeSG1bFpap8zI1NY8DNLha5sTyxwlqOZ4e_fM1Pz_jnmZjtXfWFMWEdPXA3cJNKeVE5AX6BT3jhoDLLvSyUybz0mQneOti8nTPVrcFCqnCxW5oXLBas4N0GJU8TNhnS3mYcyc5GBinw9v-5Ou-Zp99DJ29fm7oy9TnkXDe4wd1ehvj2PSt1co_c7eElnXbduk9u-foBOZzW4Fovt_QVDQGf4U_6IZl9RJLZ5odZAtKkqxCX51uKLjLo95Y2FYWPbwKnK21XeH0WRV-VzusFSILaLTxdzO0cI6cpvOqqWa2bdt4-JGcnn759OI37ixZiB6bJxDbzVQE4jpept4ozWaYFM56xwhTWVM5Bskg8EvX41CsvZZkLl5QK569ylj0iB3VT-yeEujRRNhUGcF8Jpk7I3CgrIVVK5zKnIjLZjbZ2PQs5XobxXYM3gvLRKB-N8tGdfCLyZqix6hg4_lL2PQpwKIfc2SEBNEr3GqX_pVEReY3i1zjDoWnO9AcVoIPIlaWnAreiEQhG5GhUEmamG2fvFEj3K0OrASIBWsgB-Ebk5ZCNNTHarfbNBsogjhWwcrKIPO70begSrM9MyYxHpBhp4qjP45x6fhF4w3PGOPirETnudfZXq27O28VNu11onyG5AEvwA-9GCq2X3fnM0eDHe4MPgsj0TnOf_g9JPCN3sDldyN8ROVhfbfxzwIBr-yJM958In1c7 priority: 102 providerName: Directory of Open Access Journals – databaseName: Health & Medical Collection dbid: 7X7 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3db9MwELdgCIkXBAxYYCAjTSAeQpPYTmzxgMrHNCHBE5P6ZtmO07XQpDStRvfXc5ekWQPS3iLbiWPf-T7s8-8IOcm5kdywIsxV4UNubByC3exCkRrLIyus5Xh3-Nv39Oycf52ISbfhVndhlTuZ2AjqvHK4Rz4C1QJSNgWD4cPyd4hZo_B0tUuhcZvcQegyDOnKJr3DJaRq0rvFacZCwTLeHlPyOGKjvuxdwhHybKCWGvT-_2X0npL6N4Dy7qUpC1NOoeaywmPu-mcT5b6nq04fkPudkUnHLVc8JLd8-YgcjktwsBdb-po2YZ_NfvohmXxGqNnqj1mAvUmXTXSeryk6ysDlW1oVFDrfNMiutF5iEi2KHiudlXOgB7VbeLqY2RnGT1P41Kparqt6Vj8m56dffnw6C7t0C6EDBWVCm_giA2uO57G3ijOZxxkznrHMZNYUzkGxiDzC9fjYKy9lngoX5QpXsXKWPSEHZVX6I0JdHCkbCwPWXw4KT8jUKCuhVErnEqcCMtrNtnYdFjmmxPilwSdB-mikj0b66JY-AXnbv7FscThuaPsRCdi3QwTtpqBaTXW3IHWhvCicAH_TRzxzwJQs9TJTJvHSJwY-8gbJr3Gdw685011XgAEiYpYeCzyQRnMwIMeDlrA-3bB6x0C6kw-1vubmgLzqq_FNjHkrfbWBNmjNCpCfLCBPW37rhwRSmimZ8IBkA04cjHlYU84uGvTwlDEOXmtATjqevf6rq2k9v6q3c-0ThBhgEXbwfsDQetHe0hxMfrg3-UCIRO8499nNY39O7mFHbUjfMTlYrzb-Bdh4a_uyWch_AWbMTh4 priority: 102 providerName: ProQuest – databaseName: Medknow Open Access Journals dbid: W3E link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3Nb9MwFLemISQuCBgfgYGMNIE4hDWxncSKOBTYNCHBiYlysmzH2drRpGpaje6v5704DQ1IXLhF_kjs9-X34uefCTkquM64ZmVYyNKFXJsoBL_ZhiLRho-MMIbj2eHPX5Kzc_5pIiZ7ZL2TVVktlx4lwsMEewK2x7q8iiYpCwVLeb4BWcB_fDLfajLP_WhZ7tVRsDj3Vl3wKNdrcEhX777rOm8RiSDSvxWnscBMsG_sZGvARSbbW-H6D_ndTR6N2HFf9jbmiJQ2WM1a0P-_TfvO2vZn3uXta12VurqAmusad8ebqzY5fmeJO71H7na-KR17Wtwne656QA7GFcTl8w19Rdts0fY3_AGZfESE2vqnngMJ6aJN6nMNxfgalGND65LCx9ctICxtFnj3FsVAl06rGbCRmg08XU7NFNOuKbxqWS9WdTNtHpLz05OvH87C7paG0MK6pkMTuzIFJ5AXkTOSs6yIUqYdY6lOjS6thWIxcojy4yInXZYVibCjQqLyS2vYI7Jf1ZV7QqiNRtJEQoPTWMA6KbJES5NBaZZZG1sZkOMttZXtIMzxJo0fCkIZ5I9C_ijkj_L8CcibvsfCw3f8o-17ZGDfDoG32wIQQ9WJoSqlE6UVEKa6EU8tyDJLXJZKHbvMxRpe8hrZr9A8wNCs7k45wAQRaEuNBe5joxcZkMNBS1BrO6zeCpDqzEqjwL8CVyMBrzkgL_tq7ImpcpWr19AGnWABZpcF5LGXt35KYNyZzGIekHQgiYM5D2uq6WULOp4wxiHYDchRJ7O_R3Vz0cxums1MOVRGWDXwA_lAoNXcH-4cED_cIT4wIlZbyX36X72fkTs4Dp8oeEj2V8u1ew6e48q8aPX8F029aZw priority: 102 providerName: Wolters Kluwer Health |
| Title | Deferoxamine promotes recovery of traumatic spinal cord injury by inhibiting ferroptosis |
| URI | http://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=3;spage=532;epage=541;aulast=Yao;type=0 https://www.ncbi.nlm.nih.gov/pubmed/30539824 https://www.proquest.com/docview/2382126835 https://www.proquest.com/docview/2155157933 https://d.wanfangdata.com.cn/periodical/zgsjzsyj-e201903024 https://pubmed.ncbi.nlm.nih.gov/PMC6334606 https://doaj.org/article/f9e5fc5289e047c5bb36e879a2e8e2a0 |
| Volume | 14 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3db9MwELfYJiReEDA-AqMy0gTiIV0S2_kQD6iDThPSJoSo6JtlO07XsialabV1fz13Sdo1MCFeqsp27Nh35_tdfL4j5DDlKuaKZW6aZNblSvsu4GbjilBp7mmhNce7w2fn4emAfxmK4e316GYByztNO8wnNZhfdq9_rT6CwAN-7XLfY0d-GDFXsIh3A47hy3bIHuilCMX0jG_OFEScVMneNq3rQ8s7e2gpqSqW_9879pbK-tOd8v6VyjOVj6DmqsBD7_Jn5fO-pblOHpGHDeSkvZpHHpN7Nn9C9ns5mNvTFX1LKyfQ6uv6Phl-xsCzxbWaAvqks8pXz5YUzWbg-RUtMgqDL6s4r7ScYUotivYrHecToA7VK_h3MdZj9Kam0NW8mC2Kclw-JYOT_vdPp26TfME1oK6UqwObRYDteOpbnXAWp37ElGUsUpFWmTFQLDyLwXusbxMbx2kojJcmKNOJ0ewZ2c2L3L4g1Pheon2hAAumoP5EHKpEx1Aax8YEJnHI0Xq1pWkik2OCjEsJFgrSRyJ9JNJH1vRxyPvNE7M6Ksc_2h4jATftMJ52VVDMR7IRT5klVmRGgPVpPR4ZYFEW2jhKVGBjGyjo5B2SXyIfwqsZ1VxegAli_CzZE3g8jeDQIQetliCtpl29ZiC5ZnYJsAkQRAhg2CFvNtX4JHrA5bZYQhvEtgJ2U-aQ5zW_baYEezZL4oA7JGpxYmvO7Zp8fFHFEg8Z42DDOuSw4dnbt7oZlZObcjWRNsCAA8zDAT60GFpO6zubrcV3txYfCBHINee-_I_JvSIPcLTay--A7C7mS_saYN9Cd8hONIw6ZO-4f_71W6f6eNKpJBx-f7D-bwVhVx4 |
| linkProvider | Scholars Portal |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3dTxQxEG_wiNEXo-LHKmpNUOPDyu623Y8YYw6BHAIXYyDhrbTdLhx6uycLOY8_yr_Rmf04WE14423TdtttZ_qbme10hpCVlKuYK5a5aZJZlyvtu6A3G1eESnNPC6053h3eHYaDff71QBwskD_tXRh0q2wxsQLqtDD4j3wVRAugbAgKw-fJLxezRuHpaptCo2aLbTubgslWftpaB_q-CYLNjb0vA7fJKuAawGHl6sBmESgtPPWtTjiLUz9iyjIWqUirzBgoFp7FqDTWt4mN4zQUxksTZNbEaAb93iKLnIEp0yOLaxvDb99b7BdxUiWU88OIuYJFvD4Y5b7HVudlHwKOQdY6grDKF_C_VLgiFv912bw9VXmm8iOomRZ4sF7-qPzqr0jHzfvkXqPW0n7Nhw_Igs0fkqV-Dib9eEbf0srRtPqDv0QO1jG4bfFbjUHDpZPKH9CWFE1z2FczWmQUBj-vYsnScoJpuyjayHSUnwAHUD2Dp-ORHqHHNoWuTovJWVGOykdk_0ZI8Zj08iK3Twk1vpdoXyjQN1MQsSIOVaJjKI1jYwKTOGS1XW1pmujnmITjpwQrCOkjkT4S6SNr-jjk_fyNSR3545q2a0jAeTuM2V0VFKdHsoEAmSVWZEaAhWs9HhnYBiy0cZSowMY2UNDJOyS_RGSBTzOquSABE8QYXbIv8AgcFVCHLHdaAiKYbnXLQLJBpFJe7h-HvJ5X45voZZfb4hzaoP4sALGZQ57U_DafEsgFlsQBd0jU4cTOnLs1-ei4ilceMsbBTnbISsOzl191cVSeXJSzE2kDDGrAPBzgY4eh5bi-F9pZfPfK4gMhAtly7rPr5_6K3Bns7e7Ina3h9nNyFwetHQqXSe_s9Ny-AA3zTL9stjUlhzeNJH8BToeM2Q |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9MwELfGEIgXBIyPwAAjDRAPoUls50MIoUKZNgYTD0zqm7Edp2uhSWlale5P46_jLkm7BqS97S2yHTv2nX93F5_vCNlLuYq5YpmbJpl1udK-C3qzcUWoNPe00Jrj3eEvx-HBCf_UF_0t8md1FwbdKleYWAF1Whj8R94B0QIoG4LC0Mkat4ivvf13k18uZpDCk9ZVOo2aRY7scgHmW_n2sAe0fh4E-x-_fThwmwwDrgFMVq4ObBaBAsNT3-qEszj1I6YsY5GKtMqMgWLhWYxQY32b2DhOQ2G8NEHGTYxm0O8VcjViwsc9FvXXxp6Ikyq1nB9GzBUs4vURKfc91lmXvQ44hltricQqc8D_8mFDQP7rvHltofJM5QOoWRR4xF7-qDzsN-Tk_i1ys1FwabfmyNtky-Z3yE43B-N-vKQvaOVyWv3L3yH9Hoa5LX6rMei6dFJ5BtqSopEOO2xJi4zC4PMqqiwtJ5jAi6K1TIf5CHiB6iU8nQ71EH23KXQ1LSazohyWd8nJpRDiHtnOi9w-INT4XqJ9oUDzTEHYijhUiY6hNI6NCUzikM5qtaVp4qBjOo6fEuwhpI9E-kikj6zp45BX6zcmdQyQC9q-RwKu22H07qqgmA5kAwYyS6zIjABb13o8MrAhWGjjKFGBjW2goJOXSH6JGAOfZlRzVQImiNG6ZFfgYTiqog7ZbbUEbDDt6hUDyQabSnm-kxzybF2Nb6K_XW6LObRBTVoAdjOH3K_5bT0lkBAsiQPukKjFia05t2vy4WkVuTxkjIPF7JC9hmfPv-psUI7OyuVI2gDDGzAPB3jTYmg5rm-Ithbf3Vh8IEQgV5z78OK5PyXXAT_k58Pjo0fkBo5Zexbuku3ZdG4fg6o500-qPU3J98sGkb9YsY-p |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Deferoxamine+promotes+recovery+of+traumatic+spinal+cord+injury+by+inhibiting+ferroptosis&rft.jtitle=Neural+regeneration+research&rft.au=Yao%2C+Xue&rft.au=Zhang%2C+Yan&rft.au=Hao%2C+Jian&rft.au=Duan%2C+Hui-Quan&rft.date=2019-03-01&rft.issn=1673-5374&rft.volume=14&rft.issue=3&rft.spage=532&rft_id=info:doi/10.4103%2F1673-5374.245480&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_s | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.wanfangdata.com.cn%2Fimages%2FPeriodicalImages%2Fzgsjzsyj-e%2Fzgsjzsyj-e.jpg |