Illness Progression, Recent Stress, and Morphometry of Hippocampal Subfields and Medial Prefrontal Cortex in Major Depression

• Published in: Biological psychiatry (1969) Vol. 77; no. 3; pp. 285 - 294
• Main Authors: Treadway, Michael T., Waskom, Michael L., Dillon, Daniel G., Holmes, Avram J., Park, Min Tae M., Chakravarty, M. Mallar, Dutra, Sunny J., Polli, Frida E., Iosifescu, Dan V., Fava, Maurizio, Gabrieli, John D.E., Pizzagalli, Diego A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2015
• Subjects: Adult; Amygdala - pathology; Dentate gyrus; Depressive Disorder, Major - pathology; Depressive Disorder, Major - physiopathology; Disease Progression; Female; Hippocampus; Hippocampus - pathology; Humans; MAGeT brain; Magnetic Resonance Imaging; Major depression; Male; mPFC; MRI; Organ Size; Prefrontal Cortex - pathology; Psychiatric/Mental Health; Recurrence; Stress, Psychological - pathology; Stress, Psychological - physiopathology; MAGeT brain; Dentate gyrus; mPFC; Major depression; MRI; Hippocampus

Longitudinal studies of illness progression in patients with major depressive disorder (MDD) indicate that the onset of subsequent depressive episodes becomes increasingly decoupled from external stressors. A possible mechanism underlying this phenomenon is that multiple episodes induce long-lasting...