Metabolomics analysis of the effects of chelerythrine on Ustilaginoidea virens
Rice false smut (RFS) caused by Ustilaginoidea virens is widely distributed in major rice-producing regions. Previous studies have shown that treating RFS with chelerythrine can decrease the germination of fungus spores by 86.7% and induce fungal cell apoptosis. In the present study, the effects of...
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| Published in | Journal of Pesticide Science Vol. 49; no. 2; pp. 104 - 113 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
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Japan
Pesticide Science Society of Japan
20.05.2024
Japan Science and Technology Agency |
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| Abstract | Rice false smut (RFS) caused by Ustilaginoidea virens is widely distributed in major rice-producing regions. Previous studies have shown that treating RFS with chelerythrine can decrease the germination of fungus spores by 86.7% and induce fungal cell apoptosis. In the present study, the effects of chelerythrine on the metabolism of U. virens explored using metabolomics and analyses of differentially accumulated metabolites and altered metabolic pathways. The top 15 metabolites in random forest analysis were significantly different between groups. In positive ion mode, purine, phenylalanine metabolism, phenylalanine, tyrosine, tryptophan biosynthesis, pyrimidine metabolism, and nitrogen metabolism were dominant. Alanine, aspartate, glutamate metabolism, and phenylalanine metabolism were enriched in negative ion mode. Differentially expressed genes and altered metabolic pathways of U. virens were effected by chelerythrine. The findings support future research on the prevention and treatment of RFS by chelerythrine and provide a theoretical basis for targeted drug delivery. |
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| AbstractList | Rice false smut (RFS) caused by
Ustilaginoide
a virens is widely distributed in major rice-producing regions. Previous studies have shown that treating RFS with chelerythrine can decrease the germination of fungus spores by 86.7% and induce fungal cell apoptosis. In the present study, the effects of chelerythrine on the metabolism of
U. virens
explored using metabolomics and analyses of differentially accumulated metabolites and altered metabolic pathways. The top 15 metabolites in random forest analysis were significantly different between groups. In positive ion mode, purine, phenylalanine metabolism, phenylalanine, tyrosine, tryptophan biosynthesis, pyrimidine metabolism, and nitrogen metabolism were dominant. Alanine, aspartate, glutamate metabolism, and phenylalanine metabolism were enriched in negative ion mode. Differentially expressed genes and altered metabolic pathways of
U. virens
were effected by chelerythrine. The findings support future research on the prevention and treatment of RFS by chelerythrine and provide a theoretical basis for targeted drug delivery. Rice false smut (RFS) caused by Ustilaginoidea virens is widely distributed in major rice-producing regions. Previous studies have shown that treating RFS with chelerythrine can decrease the germination of fungus spores by 86.7% and induce fungal cell apoptosis. In the present study, the effects of chelerythrine on the metabolism of U. virens explored using metabolomics and analyses of differentially accumulated metabolites and altered metabolic pathways. The top 15 metabolites in random forest analysis were significantly different between groups. In positive ion mode, purine, phenylalanine metabolism, phenylalanine, tyrosine, tryptophan biosynthesis, pyrimidine metabolism, and nitrogen metabolism were dominant. Alanine, aspartate, glutamate metabolism, and phenylalanine metabolism were enriched in negative ion mode. Differentially expressed genes and altered metabolic pathways of U. virens were effected by chelerythrine. The findings support future research on the prevention and treatment of RFS by chelerythrine and provide a theoretical basis for targeted drug delivery. Rice false smut (RFS) caused by Ustilaginoidea virens is widely distributed in major rice-producing regions. Previous studies have shown that treating RFS with chelerythrine can decrease the germination of fungus spores by 86.7% and induce fungal cell apoptosis. In the present study, the effects of chelerythrine on the metabolism of U. virens explored using metabolomics and analyses of differentially accumulated metabolites and altered metabolic pathways. The top 15 metabolites in random forest analysis were significantly different between groups. In positive ion mode, purine, phenylalanine metabolism, phenylalanine, tyrosine, tryptophan biosynthesis, pyrimidine metabolism, and nitrogen metabolism were dominant. Alanine, aspartate, glutamate metabolism, and phenylalanine metabolism were enriched in negative ion mode. Differentially expressed genes and altered metabolic pathways of U. virens were effected by chelerythrine. The findings support future research on the prevention and treatment of RFS by chelerythrine and provide a theoretical basis for targeted drug delivery.Rice false smut (RFS) caused by Ustilaginoidea virens is widely distributed in major rice-producing regions. Previous studies have shown that treating RFS with chelerythrine can decrease the germination of fungus spores by 86.7% and induce fungal cell apoptosis. In the present study, the effects of chelerythrine on the metabolism of U. virens explored using metabolomics and analyses of differentially accumulated metabolites and altered metabolic pathways. The top 15 metabolites in random forest analysis were significantly different between groups. In positive ion mode, purine, phenylalanine metabolism, phenylalanine, tyrosine, tryptophan biosynthesis, pyrimidine metabolism, and nitrogen metabolism were dominant. Alanine, aspartate, glutamate metabolism, and phenylalanine metabolism were enriched in negative ion mode. Differentially expressed genes and altered metabolic pathways of U. virens were effected by chelerythrine. The findings support future research on the prevention and treatment of RFS by chelerythrine and provide a theoretical basis for targeted drug delivery. Rice false smut (RFS) caused by a virens is widely distributed in major rice-producing regions. Previous studies have shown that treating RFS with chelerythrine can decrease the germination of fungus spores by 86.7% and induce fungal cell apoptosis. In the present study, the effects of chelerythrine on the metabolism of explored using metabolomics and analyses of differentially accumulated metabolites and altered metabolic pathways. The top 15 metabolites in random forest analysis were significantly different between groups. In positive ion mode, purine, phenylalanine metabolism, phenylalanine, tyrosine, tryptophan biosynthesis, pyrimidine metabolism, and nitrogen metabolism were dominant. Alanine, aspartate, glutamate metabolism, and phenylalanine metabolism were enriched in negative ion mode. Differentially expressed genes and altered metabolic pathways of were effected by chelerythrine. The findings support future research on the prevention and treatment of RFS by chelerythrine and provide a theoretical basis for targeted drug delivery. |
| ArticleNumber | D23-065 |
| Author | Song, Weifeng Pan, Yaqing Jiao, Zhanli Shi, Zhenghao Yu, Jiangtao Wei, Qinghui Zhai, Xihai Li, Baoying Li, Zhiyong |
| Author_xml | – sequence: 1 fullname: Wei, Qinghui organization: Institute of Plant Protection, Heilongjiang Academy of Agricultural Sciences – sequence: 2 fullname: Zhai, Xihai organization: Institute of Plant Protection, Heilongjiang Academy of Agricultural Sciences – sequence: 3 fullname: Song, Weifeng organization: Institute of Plant Protection, Heilongjiang Academy of Agricultural Sciences – sequence: 4 fullname: Li, Zhiyong organization: Institute of Plant Protection, Heilongjiang Academy of Agricultural Sciences – sequence: 5 fullname: Pan, Yaqing organization: Institute of Plant Protection, Heilongjiang Academy of Agricultural Sciences – sequence: 6 fullname: Li, Baoying organization: Institute of Plant Protection, Heilongjiang Academy of Agricultural Sciences – sequence: 7 fullname: Jiao, Zhanli organization: Institute of Plant Protection, Heilongjiang Academy of Agricultural Sciences – sequence: 8 fullname: Shi, Zhenghao organization: Institute of Plant Protection, Heilongjiang Academy of Agricultural Sciences – sequence: 9 fullname: Yu, Jiangtao organization: Yongyuan Town People's Government of Daowai District |
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| Cites_doi | 10.1038/nature10962 10.1038/nprot.2011.366 10.1094/PDIS-93-11-1202 10.1016/j.bbagen.2017.01.021 10.1016/j.phytol.2016.07.031 10.3390/ijms22020692 10.1021/jf505609z 10.1248/bpb.b17-00451 10.1007/s11046-021-00550-4 10.1016/j.fgb.2019.04.017 10.1159/000477948 10.1111/jipb.12810 10.1093/bioinformatics/bty528 10.1038/nprot.2012.024 10.3390/microorganisms10061186 10.3892/ol.2021.12870 10.1016/j.pestbp.2020.01.007 10.1016/j.stemcr.2020.12.017 10.1186/s40659-021-00340-8 10.4103/pm.pm_545_16 |
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| Keywords | Ustilaginoidea virens UPLC-MS/MS rice false smut metabolomics Chelerythrine |
| Language | English |
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Iino, R. Ishibe, S. Leo, T. Shimada, T. Watanabe, M. Ishikawa, K. Maeda, H. Kusuhara, N. Shiraki and S. Kume: Generation of human-induced pluripotent stem cell-derived functional enterocyte-like cells for pharmacokinetic studies. Stem Cell Reports 16, 295–308 (2021). – reference: 22) W. D. Bian, A. Chai, S. R. Yu and S. J. Xue: Synthesis and herbicidal activities of 1,3,4-thiadiazole derivatives of 5-(fluoro-substituted phenyl)-2-furamide. Chin. J. Org. Chem. 28, 1475–1478 (2008). – reference: 26) L. Wang and S. Gao: Identification of 5-methylcytosine-related signature for predicting prognosis in ovarian cancer. Biol. Res. 54, 18 (2021). – reference: 4) B. Hu, G. Xu, Y. Zheng, F. Tong, P. Qian, X. Pan, X. Zhou and R. Shen: Chelerythrine attenuates renal ischemia/reperfusion-induced myocardial injury by activating CSE/H2S via PKC/NF-κB pathway in diabetic rats. Kidney Blood Press. Res. 42, 379–388 (2017). – reference: 10) J. M. Egan, A. Kaur, H. A. Raja, J. J. Kellogg, N. H. Oberlies and N. B. Cech: Antimicrobial fungal endophytes from the botanical medicine goldenseal (Hydrastis canadensis). Phytochem. Lett. 17, 219–225 (2016). – reference: 1) S. A. Brooks, M. M. Anders and K. M. Yeater: Effect of cultural management practices on the severity of false smut and kernel smut of rice. Plant Dis. 93, 1202–1208 (2009). – reference: 24) F. Feng, F. Yang, W. Rong, X. Wu, J. Zhang, S. Chen, C. He and J.-M. Zhou: A Xanthomonas uridine 5′-monophosphate transferase inhibits plant immune kinases. Nature 485, 114–118 (2012). – reference: 9) W. Guo, Y. Gao, Z. Yu, Y. Xiao, Z. Zhang and H. Zhang: The adenylate cyclase UvAc1 and phosphodiesterase UvPdeH control the intracellular cAMP level, development, and pathogenicity of the rice false smut fungus Ustilaginoidea virens. Fungal Genet. Biol. 129, 65–73 (2019). – reference: 13) M. Yuan, S. B. Breitkopf, X. Yang and J. M. 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| Snippet | Rice false smut (RFS) caused by Ustilaginoidea virens is widely distributed in major rice-producing regions. Previous studies have shown that treating RFS with... Rice false smut (RFS) caused by a virens is widely distributed in major rice-producing regions. Previous studies have shown that treating RFS with... Rice false smut (RFS) caused by Ustilaginoide a virens is widely distributed in major rice-producing regions. Previous studies have shown that treating RFS... |
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| SubjectTerms | Alanine Apoptosis Biosynthesis Chelerythrine Drug delivery Drug metabolism False smut Germination Metabolic pathways Metabolites Metabolomics Negative ions Nitrogen metabolism Phenylalanine Positive ions Regular rice false smut Spores Tryptophan Tyrosine UPLC-MS/MS Ustilaginoidea virens |
| Title | Metabolomics analysis of the effects of chelerythrine on Ustilaginoidea virens |
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