Zero-mode waveguides and nanopore-based sequencing technologies accelerate single-molecule studies

• Published in: Biophysics and Physicobiology Vol. 19; p. e190032
• Main Authors: Iizuka, Ryo, Yamazaki, Hirohito, Uemura, Sotaro
• Format: Journal Article
• Language: English
• Published: The Biophysical Society of Japan 01.01.2022
• Subjects: DNA sequencer; nanopore; Review; single-molecule measurements; zero-mode waveguides

Single-molecule technologies can provide detailed information regarding molecular mechanisms and interactions that cannot easily be studied on the bulk scale; generally, individual molecular behaviors cannot be distinguished, and only average characteristics can be measured. Nevertheless, the develo...