Challenges in circulating tumor cell detection by the CellSearch system

• Published in: Molecular oncology Vol. 10; no. 3; pp. 395 - 407
• Main Authors: Andree, Kiki C., van Dalum, Guus, Terstappen, Leon W.M.M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier B.V 01.03.2016; John Wiley & Sons, Inc; John Wiley and Sons Inc
• Subjects: Animals; Biopsy; Carcinoma; Cell adhesion & migration; Cell Count; Cell Separation - methods; CellSearch; Circulating tumor cells; Colorectal cancer; Deoxyribonucleic acid; DNA; Enumeration; Epithelial cell adhesion molecule; Humans; Metastases; Metastasis; Neoplasms - blood; Neoplasms - diagnosis; Neoplasms - pathology; Neoplastic Cells, Circulating - pathology; Probability distribution; Prognosis; Rare event detection; Review; Reviews; Tumor cells; Epithelial cell adhesion molecule; Circulating tumor cells; CellSearch; Rare event detection

Enumeration and characterization of circulating tumor cells (CTC) hold the promise of a real time liquid biopsy. They are however present in a large background of hematopoietic cells making their isolation technically challenging. In 2004, the CellSearch system was introduced as the first and only F...