Haemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human-type receptors

• Published in: Nature Vol. 444; no. 7117; pp. 378 - 382
• Main Authors: Yamada, Shinya, Suzuki, Yasuo, Suzuki, Takashi, Le, Mai Q., Nidom, Chairul A., Sakai-Tagawa, Yuko, Muramoto, Yukiko, Ito, Mutsumi, Kiso, Maki, Horimoto, Taisuke, Shinya, Kyoko, Sawada, Toshihiko, Kiso, Makoto, Usui, Taiichi, Murata, Takeomi, Lin, Yipu, Hay, Alan, Haire, Lesley F., Stevens, David J., Russell, Rupert J., Gamblin, Steven J., Skehel, John J., Kawaoka, Yoshihiro
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 16.11.2006; Nature Publishing; Nature Publishing Group
• Subjects: Amino acids; Animal viral diseases; Animals; Aquatic birds; Avian flu; Binding sites; Biological and medical sciences; Cell Line; Cellular biology; Chickens; Crystal structure; Crystallography, X-Ray; Dogs; Fundamental and applied biological sciences. Psychology; Genetics; Hemagglutinin Glycoproteins, Influenza Virus - chemistry; Hemagglutinin Glycoproteins, Influenza Virus - genetics; Hemagglutinin Glycoproteins, Influenza Virus - metabolism; Human viral diseases; Humanities and Social Sciences; Humans; Infectious diseases; Influenza A Virus, H5N1 Subtype - chemistry; Influenza A Virus, H5N1 Subtype - genetics; Influenza A Virus, H5N1 Subtype - metabolism; Lethal effects; letter; Medical sciences; Microbiology; multidisciplinary; Mutation; Mutation - genetics; Pandemics; Poultry; Receptors, Virus - chemistry; Receptors, Virus - metabolism; Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains; Saccharides; Science; Science (multidisciplinary); Viral diseases; Viral diseases of the respiratory system and ent viral diseases; Virology; Human; Hemagglutinin; Host specificity; Orthomyxoviridae; Binding site; Molecular marker; Infection; Virus; Avian influenza; Influenzavirus A(H5N1); Vertebrata; Biological fixation; Influenzavirus A; Avian influenzavirus; Viral disease; Replication; Chicken; Mutation; Aves; Aminoacid sequence; Biological receptor

Pandemic potential The fact that the H5N1 bird flu virus circulating in Asia, Europe and Africa is unable to attach to human-type cell receptors has helped to prevent it from causing a worldwide epidemic of a human variant of the disease. Now a study of H5N1 isolates from some of the few humans that...