The habu genome reveals accelerated evolution of venom protein genes

Evolution of novel traits is a challenging subject in biological research. Several snake lineages developed elaborate venom systems to deliver complex protein mixtures for prey capture. To understand mechanisms involved in snake venom evolution, we decoded here the ~1.4-Gb genome of a habu, Protobot...

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Published inScientific Reports Vol. 8; no. 11300; pp. 1 - 11
Main Authors Shibata, Hiroki, Chijiwa, Takahito, Oda-Ueda, Naoko, Nakamura, Hitomi, Yamaguchi, Kazuaki, Hattori, Shousaku, Matsubara, Kazumi, Matsuda, Yoichi, Yamashita, Akifumi, Isomoto, Akiko, Mori, Kazuki, Tashiro, Kosuke, Kuhara, Satoru, Yamasaki, Shinichi, Fujie, Manabu, Goto, Hiroki, Koyanagi, Ryo, Takeuchi, Takeshi, Fukumaki, Yasuyuki, Ohno, Motonori, Shoguchi, Eiichi, Hisata, Kanako, Satoh, Noriyuki, Ogawa, Tomohisa
Format Journal Article
LanguageEnglish
Published London Springer Nature Publishing AG 26.07.2018
Nature Publishing Group UK
Nature Publishing Group
Nature Portfolio
Subjects
45
631/181/2474
631/208/212/2304
82/29
Animal behavior
Biological research
Evolution
Evolutionary genetics
Gene families
Genomes
Humanities and Social Sciences
multidisciplinary
Phylogeny
Prey
Proteins
Science
Science (multidisciplinary)
Snakes
Toxins
Venom
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Abstract Evolution of novel traits is a challenging subject in biological research. Several snake lineages developed elaborate venom systems to deliver complex protein mixtures for prey capture. To understand mechanisms involved in snake venom evolution, we decoded here the ~1.4-Gb genome of a habu, Protobothrops flavoviridis . We identified 60 snake venom protein genes (SV) and 224 non-venom paralogs (NV), belonging to 18 gene families. Molecular phylogeny reveals early divergence of SV and NV genes, suggesting that one of the four copies generated through two rounds of whole-genome duplication was modified for use as a toxin. Among them, both SV and NV genes in four major components were extensively duplicated after their diversification, but accelerated evolution is evident exclusively in the SV genes. Both venom-related SV and NV genes are significantly enriched in microchromosomes. The present study thus provides a genetic background for evolution of snake venom composition.
AbstractList Evolution of novel traits is a challenging subject in biological research. Several snake lineages developed elaborate venom systems to deliver complex protein mixtures for prey capture. To understand mechanisms involved in snake venom evolution, we decoded here the ~1.4-Gb genome of a habu, Protobothrops flavoviridis . We identified 60 snake venom protein genes (SV) and 224 non-venom paralogs (NV), belonging to 18 gene families. Molecular phylogeny reveals early divergence of SV and NV genes, suggesting that one of the four copies generated through two rounds of whole-genome duplication was modified for use as a toxin. Among them, both SV and NV genes in four major components were extensively duplicated after their diversification, but accelerated evolution is evident exclusively in the SV genes. Both venom-related SV and NV genes are significantly enriched in microchromosomes. The present study thus provides a genetic background for evolution of snake venom composition.
Evolution of novel traits is a challenging subject in biological research. Several snake lineages developed elaborate venom systems to deliver complex protein mixtures for prey capture. To understand mechanisms involved in snake venom evolution, we decoded here the ~1.4-Gb genome of a habu, Protobothrops flavoviridis. We identified 60 snake venom protein genes (SV) and 224 non-venom paralogs (NV), belonging to 18 gene families. Molecular phylogeny reveals early divergence of SV and NV genes, suggesting that one of the four copies generated through two rounds of whole-genome duplication was modified for use as a toxin. Among them, both SV and NV genes in four major components were extensively duplicated after their diversification, but accelerated evolution is evident exclusively in the SV genes. Both venom-related SV and NV genes are significantly enriched in microchromosomes. The present study thus provides a genetic background for evolution of snake venom composition.
Abstract Evolution of novel traits is a challenging subject in biological research. Several snake lineages developed elaborate venom systems to deliver complex protein mixtures for prey capture. To understand mechanisms involved in snake venom evolution, we decoded here the ~1.4-Gb genome of a habu, Protobothrops flavoviridis. We identified 60 snake venom protein genes (SV) and 224 non-venom paralogs (NV), belonging to 18 gene families. Molecular phylogeny reveals early divergence of SV and NV genes, suggesting that one of the four copies generated through two rounds of whole-genome duplication was modified for use as a toxin. Among them, both SV and NV genes in four major components were extensively duplicated after their diversification, but accelerated evolution is evident exclusively in the SV genes. Both venom-related SV and NV genes are significantly enriched in microchromosomes. The present study thus provides a genetic background for evolution of snake venom composition.
Evolution of novel traits is a challenging subject in biological research. Several snake lineages developed elaborate venom systems to deliver complex protein mixtures for prey capture. To understand mechanisms involved in snake venom evolution, we decoded here the ~1.4-Gb genome of a habu, Protobothrops flavoviridis. We identified 60 snake venom protein genes (SV) and 224 non-venom paralogs (NV), belonging to 18 gene families. Molecular phylogeny reveals early divergence of SV and NV genes, suggesting that one of the four copies generated through two rounds of whole-genome duplication was modified for use as a toxin. Among them, both SV and NV genes in four major components were extensively duplicated after their diversification, but accelerated evolution is evident exclusively in the SV genes. Both venom-related SV and NV genes are significantly enriched in microchromosomes. The present study thus provides a genetic background for evolution of snake venom composition.Evolution of novel traits is a challenging subject in biological research. Several snake lineages developed elaborate venom systems to deliver complex protein mixtures for prey capture. To understand mechanisms involved in snake venom evolution, we decoded here the ~1.4-Gb genome of a habu, Protobothrops flavoviridis. We identified 60 snake venom protein genes (SV) and 224 non-venom paralogs (NV), belonging to 18 gene families. Molecular phylogeny reveals early divergence of SV and NV genes, suggesting that one of the four copies generated through two rounds of whole-genome duplication was modified for use as a toxin. Among them, both SV and NV genes in four major components were extensively duplicated after their diversification, but accelerated evolution is evident exclusively in the SV genes. Both venom-related SV and NV genes are significantly enriched in microchromosomes. The present study thus provides a genetic background for evolution of snake venom composition.
ArticleNumber 11300
Author Noriyuki Satoh
Hiroki Shibata
Kazuki Mori
Oda-Ueda Naoko
Kanako Hisata
Akifumi Yamashita
Takeshi Takeuchi
Eiichi Shoguchi
Kazuaki Yamaguchi
Shinichi Yamasaki
Motonori Ohno
Akiko Isomoto
Ryo Koyanagi
Shousaku Hattori
Satoru Kuhara
Tomohisa Ogawa
Yasuyuki Fukumaki
Kosuke Tashiro
Takahito Chijiwa
Hitomi Nakamura
Yoichi Matsuda
Kazumi Matsubara
Manabu Fujie
Hiroki Goto
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BackLink https://cir.nii.ac.jp/crid/1572824502658512256$$DView record in CiNii
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Snippet Evolution of novel traits is a challenging subject in biological research. Several snake lineages developed elaborate venom systems to deliver complex protein...
Abstract Evolution of novel traits is a challenging subject in biological research. Several snake lineages developed elaborate venom systems to deliver complex...
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631/181/2474
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Animal behavior
Biological research
Evolution
Evolutionary genetics
Gene families
Genomes
Humanities and Social Sciences
multidisciplinary
Phylogeny
Prey
Proteins
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Science (multidisciplinary)
Snakes
Toxins
Venom
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Title The habu genome reveals accelerated evolution of venom protein genes
URI https://cir.nii.ac.jp/crid/1572824502658512256
https://link.springer.com/article/10.1038/s41598-018-28749-4
https://www.ncbi.nlm.nih.gov/pubmed/30050104
https://www.proquest.com/docview/2076903484
https://www.proquest.com/docview/2078587548
https://pubmed.ncbi.nlm.nih.gov/PMC6062510
https://doaj.org/article/501caabb95934dd19843c72b93db0010
Volume 8
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