The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset

• Published in: Nature (London) Vol. 471; no. 7339; pp. 513 - 517
• Main Authors: Ceol, Craig J., Houvras, Yariv, Jane-Valbuena, Judit, Bilodeau, Steve, Orlando, David A., Battisti, Valentine, Fritsch, Lauriane, Lin, William M., Hollmann, Travis J., Ferré, Fabrizio, Bourque, Caitlin, Burke, Christopher J., Turner, Laura, Uong, Audrey, Johnson, Laura A., Beroukhim, Rameen, Mermel, Craig H., Loda, Massimo, Ait-Si-Ali, Slimane, Garraway, Levi A., Young, Richard A., Zon, Leonard I.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 24.03.2011; Nature Publishing Group
• Subjects: 692/420/2489/68; 692/699/67/1813/1634; Age of Onset; Amino Acid Substitution; Animals; Animals, Genetically Modified; Biological and medical sciences; Cancer; Cell Transformation, Neoplastic - genetics; Chromatin Immunoprecipitation; Chromosomes, Human, Pair 1 - genetics; Danio rerio; Dermatology; Development and progression; Disease Models, Animal; DNA Copy Number Variations - genetics; Gene Amplification - genetics; Gene expression; Gene Expression Profiling; Gene Expression Regulation, Neoplastic - genetics; Genes, Homeobox - genetics; Genetic aspects; Genetics; Histone Methyltransferases; Histone-Lysine N-Methyltransferase - genetics; Histone-Lysine N-Methyltransferase - metabolism; Humanities and Social Sciences; Humans; letter; Life Sciences; Medical sciences; Melanocytes - cytology; Melanocytes - enzymology; Melanocytes - metabolism; Melanocytes - pathology; Melanoma; Melanoma - enzymology; Melanoma - genetics; Melanoma - pathology; Methyltransferases; multidisciplinary; Mutation; Nevus - enzymology; Oncogenes - genetics; Physiological aspects; Protein Methyltransferases - genetics; Protein Methyltransferases - metabolism; Proteins; Proto-Oncogene Proteins B-raf - chemistry; Proto-Oncogene Proteins B-raf - genetics; Proto-Oncogene Proteins B-raf - metabolism; Risk factors; Science; Science (multidisciplinary); Zebrafish - genetics; United States; Human; Tumor; Mutation; Genetic determinism; Melanoma

Oncogenes BRAF(V600E) and SETDB1 in melanoma Transgenic zebrafish carrying the human oncogene BRAF(V600E) , the most common mutation in melanoma patients, provide a convenient model for melanoma. Two papers from Leonard Zon and colleagues demonstrate the potential of this system in the study of canc...