Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population

• Published in: Nature Vol. 439; no. 7074; pp. 344 - 348
• Main Authors: Vignuzzi, Marco, Stone, Jeffrey K., Arnold, Jamie J., Cameron, Craig E., Andino, Raul
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 19.01.2006; Nature Publishing; Nature Publishing Group
• Subjects: Animals; Biological and medical sciences; Biological Evolution; Fundamental and applied biological sciences. Psychology; Genome, Viral; Genomes; Genomics; Growth conditions; HeLa Cells; Humanities and Social Sciences; Humans; Hypotheses; Lethal Dose 50; letter; Mathematical models; Mice; Microbiology; Models, Biological; multidisciplinary; Mutagenesis - genetics; Mutation; Organ Specificity; Pathogenesis; Phenotype; Poliovirus; Poliovirus - genetics; Poliovirus - pathogenicity; Poliovirus - physiology; Population dynamics; Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains; RNA polymerase; Science; Science (multidisciplinary); Selection, Genetic; Variance analysis; Virology; Virus Replication; Viruses; United States > US; California; Pennsylvania; Virus; Enterovirus; Genetic diversity; Poliovirus; Picornaviridae; Pathogenesis

Viruses, where wrong is right The replication of RNA viruses is associated with a higher mutation rate than is seen in organisms using DNA as their genetic material. This can produce nonviable individuals but also, it has been suggested, some useful variation that could enhance the fitness of virus...