Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population - Vignuzzi, Marco; Stone, Jeffrey K.; Arnold, Jamie J.; Cameron, Craig E.; Andino, Raul (Nature, 2006)
Keywords: Animals; Biological and medical sciences; Biological Evolution; Fundamental and applied biological sciences. Psychology; Genome, Viral; Genomes; Genomics; Growth conditions; HeLa Cells; Humanities and Social Sciences; Humans; Hypotheses; Lethal Dose 50; letter; Mathematical models; Mice; Microbiology; Models, Biological; multidisciplinary; Mutagenesis - genetics; Mutation; Organ Specificity; Pathogenesis; Phenotype; Poliovirus; Poliovirus - genetics; Poliovirus - pathogenicity; Poliovirus - physiology; Population dynamics; Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains; RNA polymerase; Science; Science (multidisciplinary); Selection, Genetic; Variance analysis; Virology; Virus Replication; Viruses; United States--US; California; Pennsylvania; Virus; Enterovirus; Genetic diversity; Poliovirus; Picornaviridae; Pathogenesis