Sleep: A Novel Mechanistic Pathway, Biomarker, and Treatment Target in the Pathology of Alzheimer's Disease?

• Published in: Trends in neurosciences (Regular ed.) Vol. 39; no. 8; pp. 552 - 566
• Main Authors: Mander, Bryce A., Winer, Joseph R., Jagust, William J., Walker, Matthew P.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.08.2016; Elsevier Sequoia S.A; Elsevier - Cell Press
• Subjects: aging; Aging - physiology; Alzheimer Disease - diagnosis; Alzheimer Disease - physiopathology; Alzheimer Disease - therapy; Alzheimer's disease; amyloid-β; Animals; BASIC BIOLOGICAL SCIENCES; Brain; cognitive decline; Eye movements; Humans; Medical treatment; Memory; Neurology; Neurosciences; Sleep; Sleep - drug effects; Sleep - physiology; sleep; amyloid-β; aging; cognitive decline; Alzheimer's disease

Sleep disruption appears to be a core component of Alzheimer's disease (AD) and its pathophysiology. Signature abnormalities of sleep emerge before clinical onset of AD. Moreover, insufficient sleep facilitates accumulation of amyloid-β (Aβ), potentially triggering earlier cognitive decline and...