An epigenome-wide association study of total serum immunoglobulin E concentration

• Published in: Nature (London) Vol. 520; no. 7549; pp. 670 - 674
• Main Authors: Liang, Liming, Willis-Owen, Saffron A. G., Laprise, Catherine, Wong, Kenny C. C., Davies, Gwyneth A., Hudson, Thomas J., Binia, Aristea, Hopkin, Julian M., Yang, Ivana V., Grundberg, Elin, Busche, Stephan, Hudson, Marie, Rönnblom, Lars, Pastinen, Tomi M., Schwartz, David A., Lathrop, G. Mark, Moffatt, Miriam F., Cookson, William O. C. M.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 30.04.2015; Nature Publishing Group
• Subjects: 45; 45/43; 631/208/176/1988; Adolescent; Adult; Allergies; Asthma; Asthma - blood; Asthma - genetics; Child; CpG Islands - genetics; DNA methylation; DNA Methylation - genetics; Eosinophils - cytology; Eosinophils - metabolism; Epigenesis, Genetic - genetics; Epigenetics; Female; Gene expression; Genetic aspects; Genetic Association Studies; Genome, Human - genetics; Genome-wide association studies; Genomes; Hay fever; Humanities and Social Sciences; Humans; Immunoglobulin E; Immunoglobulin E - blood; Immunoglobulins; Inflammation Mediators; letter; Male; Methylation; Middle Aged; Mitochondrial Proteins - genetics; multidisciplinary; Pedigree; Polymorphism, Single Nucleotide - genetics; Proteins; Science; Studies; Systematic review; Transcription factors; Transcription Factors - genetics; Young Adult
• ISSN: 0028-0836; 1476-4687; 1476-4687
• DOI: 10.1038/nature14125

A survey of epigenetic associations between serum immunoglobulin E concentrations indicating allergy and methylation at CpG islands in families and a population sample has revealed associations at 36 loci that harbour genes encoding proteins including eosinophil products and phospholipid inflammator...