Lack of Efficacy of Ulinastatin Therapy During Cardiopulmonary Bypass Surgery

• Published in: Chinese medical journal Vol. 128; no. 23; pp. 3138 - 3142
• Main Authors: Qiu, Yan, Lin, Jing, Yang, Yang, Zhou, Jing, Gong, Li-Na, Qin, Zhen, Du, Lei
• Format: Journal Article
• Language: English
• Published: China Medknow Publications Pvt Ltd 05.12.2015; Medknow Publications and Media Pvt. Ltd; Lippincott Williams & Wilkins Ovid Technologies; Department of Anesthesiology and Translational Neuroscience Center,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China%Department of Anesthesiology,Affiliated Hospital of Guiyang Medical College,Guiyang,Guizhou 550004,China%Department of Lab Medicine,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China; Medknow Publications & Media Pvt Ltd; Wolters Kluwer
• Subjects: Acute Kidney Injury - etiology; Adult; Anesthesiology; Cardiac Surgical Procedures - adverse effects; Cardiopulmonary Bypass - adverse effects; Cardiopulmonary Bypass; Outcomes; Ulinastatin; Valves Replacement; Coronary artery bypass; Dosage and administration; Female; Glycoproteins - therapeutic use; Health aspects; Heart; Heart surgery; Hospitals; Humans; Inflammation; Ischemia; Length of Stay; Logistic回归; logistic回归分析; Male; Middle Aged; Neurosciences; Neutrophils; Original; Patients; Pharmacology; Postoperative Complications; Pulmonary arteries; Respiratory Distress Syndrome, Adult - etiology; Retrospective Studies; Rodents; Studies; Tumor necrosis factor-TNF; Ulinastatin; Variance analysis; Ventilators; 体外循环; 急性肺损伤; 手术; 疗效; 胰蛋白酶抑制剂; 药物治疗; China; United States > US; Valves Replacement; Cardiopulmonary Bypass; Ulinastatin; Outcomes

Background： It was believed that inflammatory response induced by cardiopulmonary bypass （CPB） was blamed for complications after cardiac surgery. To improve the outcome, many pharmacological interventions have been applied to attenuate inflammatory response during CPB. The objective of this study w...