Siglec-mediated regulation of immune cell function in disease

• Published in: Nature reviews. Immunology Vol. 14; no. 10; pp. 653 - 666
• Main Authors: Macauley, Matthew S., Crocker, Paul R., Paulson, James C.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.10.2014; Nature Publishing Group
• Subjects: 631/250/1619; 631/250/2161; 631/250/249; 631/250/516; Alzheimer's disease; Animals; Autoimmune diseases; Biological control systems; Biomedicine; Disease; Disease Resistance - immunology; Disease Susceptibility - immunology; Granulocytes; Health aspects; Humans; Immune response; Immune System - cytology; Immune System - immunology; Immune System - metabolism; Immunoglobulins; Immunological research; Immunology; Infectious diseases; Kinases; Lectins; Leukemia; Ligands; Mammals; Models, Immunological; N-Acetylneuraminic Acid - immunology; N-Acetylneuraminic Acid - metabolism; Neurodegeneration; Neutrophils; Pathogens; Phosphatase; Physiological aspects; Polysaccharides - immunology; Polysaccharides - metabolism; Protein Binding - immunology; review-article; Sialic Acid Binding Immunoglobulin-like Lectins - immunology; Sialic Acid Binding Immunoglobulin-like Lectins - metabolism

Key Points Siglecs are a family sialic acid-binding immunoglobulin-like co-receptors that are expressed on most cells of the innate and adaptive immune systems. As Siglecs recognize sialic acid-containing glycans that are expressed on all mammalian cells, they can help immune cells to discriminate b...