Clues to Neuro-Degeneration in Niemann-Pick Type C Disease from Global Gene Expression Profiling - Reddy, Jonathan V.; Ganley, Ian G.; Pfeffer, Suzanne R. (PloS one, 2006)
Keywords: Alzheimer Disease - etiology; Alzheimer Disease - metabolism; Alzheimer's disease; Alzheimers disease; Amino Acid Substitution; Amyloid beta-protein; Amyloid precursor protein; Analysis; Biochemistry; Biochemistry/Membrane Proteins and Energy Transduction; Brain diseases; Calcium; Calcium - metabolism; Carrier Proteins - genetics; Cell Biology/Neuronal and Glial Cell Biology; Cells, Cultured; Cholesterol; Cholesterol - metabolism; Degeneration; DNA microarrays; Fibroblasts; Free radicals; Gene expression; Gene Expression Profiling; Genes; Genetic aspects; Genetic disorders; Genetics and Genomics/Genetics of Disease; Genomes; Genomics; Glycosphingolipids; Homeostasis; Homozygote; Humans; Intracellular; Lipids; Lymphoma; Lymphomas; Membrane Glycoproteins - genetics; Membrane trafficking; Metabolic disorders; Metals; Mutation; Nerve Degeneration - etiology; Nerve Degeneration - genetics; Nerve Degeneration - metabolism; Nervous system diseases; Neurodegeneration; Neurodegenerative diseases; Neurological Disorders/Alzheimer Disease; Neuropathology; Niemann-Pick disease; Niemann-Pick Disease, Type C - etiology; Niemann-Pick Disease, Type C - genetics; Niemann-Pick Disease, Type C - metabolism; Npc1 protein; Oxidative Stress; Physiological aspects; Point Mutation; Protein binding; Proteins; Sterols; Tau protein; tau Proteins - metabolism; United States--US; California