Biosynthesis of Vitamin C by Yeast Leads to Increased Stress Resistance

• Published in: PloS one Vol. 2; no. 10; p. e1092
• Main Authors: Branduardi, Paola, Fossati, Tiziana, Sauer, Michael, Pagani, Roberto, Mattanovich, Diethard, Porro, Danilo
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 31.10.2007; Public Library of Science (PLoS)
• Subjects: Animals; Antioxidants; Arabidopsis thaliana; Ascorbic acid; Ascorbic Acid - biosynthesis; Ascorbic Acid - chemistry; Baking yeast; Biochemistry/Biocatalysis; Bioengineering; Biosynthesis; Biotechnology; Biotechnology/Applied Microbiology; Biotechnology/Biocatalysis; Biotechnology/Bioengineering; Biotechnology/Plant Biotechnology; Cell Biology/Cell Growth and Division; Cell Biology/Cellular Death and Stress Responses; Cell Biology/Microbial Growth and Development; Cell Biology/Microbial Physiology and Metabolism; Cloning; Dehydrogenases; Deoxyribonucleic acid; Diastereomers; DNA; Drug resistance; E coli; Environmental effects; Environmental stress; Enzymes; Escherichia coli; Eukaryotes; Fermentation; Fungal Proteins - chemistry; Genotoxicity; Glucose; Glucose - metabolism; Hydrogen peroxide; Hydrogen Peroxide - chemistry; Hydrogen-Ion Concentration; Industrial production; Laboratories; Life sciences; Lung cancer; Metabolism; Microbiology; Microbiology/Applied Microbiology; Microbiology/Microbial Growth and Development; Microbiology/Microbial Physiology and Metabolism; Microscopy, Fluorescence; Models, Biological; Natural resources; Organic acids; Organisms; Oxidation resistance; Oxidative stress; Oxygen; Oxygen - metabolism; pH effects; Phosphatase; Physiological aspects; Plasmids; Polyethylene glycol; Rats; Reactive Oxygen Species; Recombinant Proteins - chemistry; Saccharomyces cerevisiae; Saccharomyces cerevisiae - metabolism; Stresses; Vitamin C; Yeast; Austria

In industrial large scale bio-reactions micro-organisms are generally exposed to a variety of environmental stresses, which might be detrimental for growth and productivity. Reactive oxygen species (ROS) play a key role among the common stress factors--directly--through incomplete reduction of O(2)...