Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease - Badarinarayan, Nandini; Bis, Joshua C; Heilmann-Heimbach, Stefanie; Sleegers, Kristel; Vronskaya, Maria; White, Charles C; Hamilton-Nelson, Kara L; Choi, Seung-Hoan; Forstner, Andreas J; Bacq, Delphine; Brody, Jennifer A; Wolters, Frank J; et al. (Nature genetics, 2017)
Keywords: 45/43; 631/208/205/2138; 692/699/375/365/1283; Adaptor Proteins, Signal Transducing - genetics; Agriculture; Alzheimer Disease - genetics; Alzheimer's disease; Amino Acid Sequence; Animal Genetics and Genomics; Bioinformatics; Biomedicine; Cancer Research; Case-Control Studies; Consortia; Development and progression; Disease control; DNA methylation; DNA microarrays; Exome - genetics; Gene Expression Profiling; Gene Frequency; Gene Function; Genes; Genetic aspects; Genetic Predisposition to Disease - genetics; Genetic variation; Genomes; Genomics; Genotype; Genotypes; Genotyping; Human Genetics; Humans; Immune response; Immune system; Immunity; Immunity (Disease); Immunity, Innate - genetics; Innate immunity; letter; Life Sciences; Linkage Disequilibrium; Membrane Glycoproteins - genetics; Microglia; Microglia - metabolism; Neurodegenerative diseases; Neurons and Cognition; Odds Ratio; Phospholipase C gamma - genetics; Physiological aspects; Polymorphism, Single Nucleotide; Protein interaction; Protein Interaction Maps - genetics; Proteins; Receptors, Immunologic - genetics; Sequence Homology, Amino Acid; Studies; United States; United Kingdom; Netherlands