Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease
Sven van der Lee, Julie Williams, Gerard Schellenberg and colleagues identify rare coding variants in PLCG2 , ABI3 and TREM2 associated with Alzheimer's disease. These genes are highly expressed in microglia and provide additional evidence that the microglia-mediated immune response contributes...
Saved in:
| Published in | Nature genetics Vol. 49; no. 9; pp. 1373 - 1384 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York
Nature Publishing Group US
01.09.2017
Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Sven van der Lee, Julie Williams, Gerard Schellenberg and colleagues identify rare coding variants in
PLCG2
,
ABI3
and
TREM2
associated with Alzheimer's disease. These genes are highly expressed in microglia and provide additional evidence that the microglia-mediated immune response contributes to the development of Alzheimer's disease.
We identified rare coding variants associated with Alzheimer's disease in a three-stage case–control study of 85,133 subjects. In stage 1, we genotyped 34,174 samples using a whole-exome microarray. In stage 2, we tested associated variants (
P
< 1 × 10
−4
) in 35,962 independent samples using
de novo
genotyping and imputed genotypes. In stage 3, we used an additional 14,997 samples to test the most significant stage 2 associations (
P
< 5 × 10
−8
) using imputed genotypes. We observed three new genome-wide significant nonsynonymous variants associated with Alzheimer's disease: a protective variant in
PLCG2
(rs72824905: p.Pro522Arg,
P
= 5.38 × 10
−10
, odds ratio (OR) = 0.68, minor allele frequency (MAF)
cases
= 0.0059, MAF
controls
= 0.0093), a risk variant in
ABI3
(rs616338: p.Ser209Phe,
P
= 4.56 × 10
−10
, OR = 1.43, MAF
cases
= 0.011, MAF
controls
= 0.008), and a new genome-wide significant variant in
TREM2
(rs143332484: p.Arg62His,
P
= 1.55 × 10
−14
, OR = 1.67, MAF
cases
= 0.0143, MAF
controls
= 0.0089), a known susceptibility gene for Alzheimer's disease. These protein-altering changes are in genes highly expressed in microglia and highlight an immune-related protein–protein interaction network enriched for previously identified risk genes in Alzheimer's disease. These genetic findings provide additional evidence that the microglia-mediated innate immune response contributes directly to the development of Alzheimer's disease. |
|---|---|
| AbstractList | Sven van der Lee, Julie Williams, Gerard Schellenberg and colleagues identify rare coding variants in
PLCG2
,
ABI3
and
TREM2
associated with Alzheimer's disease. These genes are highly expressed in microglia and provide additional evidence that the microglia-mediated immune response contributes to the development of Alzheimer's disease.
We identified rare coding variants associated with Alzheimer's disease in a three-stage case–control study of 85,133 subjects. In stage 1, we genotyped 34,174 samples using a whole-exome microarray. In stage 2, we tested associated variants (
P
< 1 × 10
−4
) in 35,962 independent samples using
de novo
genotyping and imputed genotypes. In stage 3, we used an additional 14,997 samples to test the most significant stage 2 associations (
P
< 5 × 10
−8
) using imputed genotypes. We observed three new genome-wide significant nonsynonymous variants associated with Alzheimer's disease: a protective variant in
PLCG2
(rs72824905: p.Pro522Arg,
P
= 5.38 × 10
−10
, odds ratio (OR) = 0.68, minor allele frequency (MAF)
cases
= 0.0059, MAF
controls
= 0.0093), a risk variant in
ABI3
(rs616338: p.Ser209Phe,
P
= 4.56 × 10
−10
, OR = 1.43, MAF
cases
= 0.011, MAF
controls
= 0.008), and a new genome-wide significant variant in
TREM2
(rs143332484: p.Arg62His,
P
= 1.55 × 10
−14
, OR = 1.67, MAF
cases
= 0.0143, MAF
controls
= 0.0089), a known susceptibility gene for Alzheimer's disease. These protein-altering changes are in genes highly expressed in microglia and highlight an immune-related protein–protein interaction network enriched for previously identified risk genes in Alzheimer's disease. These genetic findings provide additional evidence that the microglia-mediated innate immune response contributes directly to the development of Alzheimer's disease. We identified rare coding variants associated with Alzheimer's disease in a three-stage case-control study of 85,133 subjects. In stage 1, we genotyped 34,174 samples using a whole-exome microarray. In stage 2, we tested associated variants (P < 1 × 10-4) in 35,962 independent samples using de novo genotyping and imputed genotypes. In stage 3, we used an additional 14,997 samples to test the most significant stage 2 associations (P < 5 × 10-8) using imputed genotypes. We observed three new genome-wide significant nonsynonymous variants associated with Alzheimer's disease: a protective variant in PLCG2 (rs72824905: p.Pro522Arg, P = 5.38 × 10-10, odds ratio (OR) = 0.68, minor allele frequency (MAF)cases = 0.0059, MAFcontrols = 0.0093), a risk variant in ABI3 (rs616338: p.Ser209Phe, P = 4.56 × 10-10, OR = 1.43, MAFcases = 0.011, MAFcontrols = 0.008), and a new genome-wide significant variant in TREM2 (rs143332484: p.Arg62His, P = 1.55 × 10-14, OR = 1.67, MAFcases = 0.0143, MAFcontrols = 0.0089), a known susceptibility gene for Alzheimer's disease. These protein-altering changes are in genes highly expressed in microglia and highlight an immune-related protein-protein interaction network enriched for previously identified risk genes in Alzheimer's disease. These genetic findings provide additional evidence that the microglia-mediated innate immune response contributes directly to the development of Alzheimer's disease. We identified rare coding variants associated with Alzheimer's disease in a three-stage case-control study of 85,133 subjects. In stage 1, we genotyped 34,174 samples using a whole-exome microarray. In stage 2, we tested associated variants (P < 1 x 10(-4)) in 35,962 independent samples using de novo genotyping and imputed genotypes. In stage 3, we used an additional 14,997 samples to test the most significant stage 2 associations (P < 5 x 10(-8)) using imputed genotypes. We observed three new genome-wide significant nonsynonymous variants associated with Alzheimer's disease: a protective variant in PLCG2 (rs72824905: p. Pro522Arg, P = 5.38 x 10(-10), odds ratio (OR) = 0.68, minor allele frequency (MAF) cases = 0.0059, MAFcontrols = 0.0093), a risk variant in ABI3 (rs616338: p. Ser209Phe, P = 4.56 x 10-10, OR = 1.43, MAFcases = 0.011, MAFcontrols = 0.008), and a new genome-wide significant variant in TREM2 (rs143332484: p. Arg62His, P = 1.55 x 10(-14), OR = 1.67, MAFcases = 0.0143, MAFcontrols = 0.0089), a known susceptibility gene for Alzheimer's disease. These protein-altering changes are in genes highly expressed in microglia and highlight an immune-related protein-protein interaction network enriched for previously identified risk genes in Alzheimer's disease. These genetic findings provide additional evidence that the microglia-mediated innate immune response contributes directly to the development of Alzheimer's disease. We identified rare coding variants associated with Alzheimer's disease in a three-stage case-control study of 85,133 subjects. In stage 1, we genotyped 34,174 samples using a whole-exome microarray. In stage 2, we tested associated variants (P < 1 × 10 ) in 35,962 independent samples using de novo genotyping and imputed genotypes. In stage 3, we used an additional 14,997 samples to test the most significant stage 2 associations (P < 5 × 10 ) using imputed genotypes. We observed three new genome-wide significant nonsynonymous variants associated with Alzheimer's disease: a protective variant in PLCG2 (rs72824905: p.Pro522Arg, P = 5.38 × 10 , odds ratio (OR) = 0.68, minor allele frequency (MAF) = 0.0059, MAF = 0.0093), a risk variant in ABI3 (rs616338: p.Ser209Phe, P = 4.56 × 10 , OR = 1.43, MAF = 0.011, MAF = 0.008), and a new genome-wide significant variant in TREM2 (rs143332484: p.Arg62His, P = 1.55 × 10 , OR = 1.67, MAF = 0.0143, MAF = 0.0089), a known susceptibility gene for Alzheimer's disease. These protein-altering changes are in genes highly expressed in microglia and highlight an immune-related protein-protein interaction network enriched for previously identified risk genes in Alzheimer's disease. These genetic findings provide additional evidence that the microglia-mediated innate immune response contributes directly to the development of Alzheimer's disease. We identified rare coding variants associated with Alzheimer's disease in a three-stage case-control study of 85,133 subjects. In stage 1, we genotyped 34,174 samples using a whole-exome microarray. In stage 2, we tested associated variants (P < 1 × 10-4) in 35,962 independent samples using de novo genotyping and imputed genotypes. In stage 3, we used an additional 14,997 samples to test the most significant stage 2 associations (P < 5 × 10-8) using imputed genotypes. We observed three new genome-wide significant nonsynonymous variants associated with Alzheimer's disease: a protective variant in PLCG2 (rs72824905: p.Pro522Arg, P = 5.38 × 10-10, odds ratio (OR) = 0.68, minor allele frequency (MAF)cases = 0.0059, MAFcontrols = 0.0093), a risk variant in ABI3 (rs616338: p.Ser209Phe, P = 4.56 × 10-10, OR = 1.43, MAFcases = 0.011, MAFcontrols = 0.008), and a new genome-wide significant variant in TREM2 (rs143332484: p.Arg62His, P = 1.55 × 10-14, OR = 1.67, MAFcases = 0.0143, MAFcontrols = 0.0089), a known susceptibility gene for Alzheimer's disease. These protein-altering changes are in genes highly expressed in microglia and highlight an immune-related protein-protein interaction network enriched for previously identified risk genes in Alzheimer's disease. These genetic findings provide additional evidence that the microglia-mediated innate immune response contributes directly to the development of Alzheimer's disease.We identified rare coding variants associated with Alzheimer's disease in a three-stage case-control study of 85,133 subjects. In stage 1, we genotyped 34,174 samples using a whole-exome microarray. In stage 2, we tested associated variants (P < 1 × 10-4) in 35,962 independent samples using de novo genotyping and imputed genotypes. In stage 3, we used an additional 14,997 samples to test the most significant stage 2 associations (P < 5 × 10-8) using imputed genotypes. We observed three new genome-wide significant nonsynonymous variants associated with Alzheimer's disease: a protective variant in PLCG2 (rs72824905: p.Pro522Arg, P = 5.38 × 10-10, odds ratio (OR) = 0.68, minor allele frequency (MAF)cases = 0.0059, MAFcontrols = 0.0093), a risk variant in ABI3 (rs616338: p.Ser209Phe, P = 4.56 × 10-10, OR = 1.43, MAFcases = 0.011, MAFcontrols = 0.008), and a new genome-wide significant variant in TREM2 (rs143332484: p.Arg62His, P = 1.55 × 10-14, OR = 1.67, MAFcases = 0.0143, MAFcontrols = 0.0089), a known susceptibility gene for Alzheimer's disease. These protein-altering changes are in genes highly expressed in microglia and highlight an immune-related protein-protein interaction network enriched for previously identified risk genes in Alzheimer's disease. These genetic findings provide additional evidence that the microglia-mediated innate immune response contributes directly to the development of Alzheimer's disease. We identified rare coding variants associated with Alzheimer’s disease (AD) in a 3-stage case-control study of 85,133 subjects. In stage 1, 34,174 samples were genotyped using a whole-exome microarray. In stage 2, we tested associated variants ( P <1×10 -4 ) in 35,962 independent samples using de novo genotyping and imputed genotypes. In stage 3, an additional 14,997 samples were used to test the most significant stage 2 associations ( P <5×10 -8 ) using imputed genotypes. We observed 3 novel genome-wide significant (GWS) AD associated non-synonymous variants; a protective variant in PLCG2 (rs72824905/p.P522R, P =5.38×10 -10 , OR=0.68, MAF cases =0.0059, MAF controls =0.0093), a risk variant in ABI3 (rs616338/p.S209F, P =4.56×10 -10 , OR=1.43, MAF cases =0.011, MAF controls =0.008), and a novel GWS variant in TREM2 (rs143332484/p.R62H, P =1.55×10 -14 , OR=1.67, MAF cases =0.0143, MAF controls =0.0089), a known AD susceptibility gene. These protein-coding changes are in genes highly expressed in microglia and highlight an immune-related protein-protein interaction network enriched for previously identified AD risk genes. These genetic findings provide additional evidence that the microglia-mediated innate immune response contributes directly to AD development. |
| Audience | Academic |
| Author | Ritchie, Karen Murrell, Jill R Buxbaum, Joseph D Boada, Merce Peters, Oliver Duara, Ranjan Albin, Roger L Ciaramella, Antonio Kuzma, Amanda B Fornage, Myriam Green, Robert C Amin, Najaf Jakobsdottir, Johanna Weintraub, Sandra Heun, Reinhard Burns, Jeffrey M Galimberti, Daniela Tarraga, Lluis Baldwin, Clinton T Spina, Salvatore Kilander, Lena Hughes, Joseph T Herms, Stefan Vonsattel, Jean Paul Eiriksdottir, Gudny Faber, Kelley M Kaye, Jeffrey A Bonuccelli, Ubaldo Apostolova, Liana G Royall, Donald R Masullo, Carlo Vandenberghe, Rik Kunkle, Brian W Reiman, Eric M Proitsi, Petra Carrell, David Rosenberg, Roger N Hakonarson, Hakon Moebus, Susanne Boerwinkle, Eric Beecham, Gary W Urbano, Maria Fenoglio, Chiara Lin, Honghuang Hampel, Harald Whitehead, Patrice Bowen, James D Corcoran, Chris Burgess, Jeremy D Lupton, Michelle K Smith, Albert V Yu, Lei Launer, Lenore J Burke, James R Paulson, Henry L Schmidt, Reinhold Hiltunen, Mikko Levy, Daniel Serpente, Maria Riemenschneider, Matthias Leber, Markus Sacchinelli, Eleonora McGuinness, Bernadette White, Cha |
| AuthorAffiliation | 59 National Heart, Lung, and Blood Institute, Bethesda, MD, USA 89 Office of Strategy and Measurement, University of North Texas Health Science Center, Fort Worth, Texas, USA 116 Regional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy 113 Arizona Alzheimer’s Consortium, Phoenix, Arizona, USA 23 Taub Institute on Alzheimer’s Disease and the Aging Brain, Department of Neurology, Columbia University, New York, New York, USA 25 Department of Neurology, Columbia University, New York, New York, USA 96 Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA 30 German Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany 32 Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA 154 Neurogenetics Laboratory, Division of Neurosciences, Centre for Applied Medical Research, University of Navarra School of Medicine, Pamplona, Spain 49 Neurodegenerative Disease Unit, Department of Basic Medicine, Neuroscience, and Sense |
| AuthorAffiliation_xml | – name: 84 Institute of Molecular Biology and Biochemistry, Medical University Graz, Austria – name: 24 Gertrude H. Sergievsky Center, Columbia University, New York, New York, USA – name: 108 Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, USA – name: 131 Department of Psychiatry, Charité University Medicine, Berlin, Germany – name: 143 Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK – name: 112 Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona, USA – name: 111 Netherlands Consortium on Health Aging and National Genomics Initiative, Leiden, The Netherlands – name: 155 Department of Neurology, Complejo Asistencial Universitario de Palencia, Spain – name: 13 Department of Genomics, Life & Brain Center, University of Bonn, 53127, Bonn, Germany – name: 150 Memory Research and Resources Center, CMRR of Montpellier, Department of Neurology, Hospital Gui de Chauliac, Montpellier, France – name: 75 Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA – name: 64 Department of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden – name: 90 Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA – name: 9 CEA / Institut de Génomique, Centre National de Génotypage, F-91057 Evry, France – name: 144 Department of Psychiatry, University of Oxford, Oxford, UK – name: 118 Departments of Psychiatry, Medicine, Family & Community Medicine, South Texas Veterans Health Administration Geriatric Research Education & Clinical Center (GRECC), UT Health Science Center at San Antonio, San Antonio, Texas, USA – name: 83 Department of Neurology, Catholic University of Rome, Rome, Italy – name: 103 Centre for Public Health, University of Iceland, Reykjavik, Iceland – name: 137 Department of Medical Sciences, Institute of Biomedicine iBiMED, University of Aveiro, Aveiro, Portugal – name: 16 Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA – name: 52 Geriatric Medicine-Memory Unit and Rare Disease Centre, University of Bari Aldo Moro, Bari, Italy – name: 132 NEUROFARBA (Department of Neuroscience, Psychology, Drug Research and Child Health), University of Florence, Florence, Italy – name: 15 Framingham Heart Study, Framingham, MA, USA – name: 22 School of Public Health, Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA – name: 55 Department of Neurology, Rouen University Hospital, Rouen, France – name: 119 Institute for Stroke and Dementia Research, Klinikum der Universität München, Munich, Germany – name: 87 Department of Neurology, University of Washington, Seattle, WA, USA – name: 54 Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy – name: 72 Department of Primary Medical Care, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany – name: 33 Faculty of Medicine, University of Iceland, Reykjavik, Iceland – name: 6 University Lille, U1167 – Excellence Laboratory LabEx DISTALZ, F-59000 Lille – name: 147 Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, KIADRC, Novum Floor 5, S14186 Stockholm, Sweden – name: 12 Institute of Human Genetics, University of Bonn, Bonn, Germany – name: 35 School of Biotechnology, Dublin City University, Dublin 9, Ireland – name: 21 Division of Medical Genetics, University Hospital and Department of Biomedicine, University of Basel, CH-4058, Basel, Switzerland – name: 142 Memory Unit, Neurology Department and Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Autonomous University Barcelona, Barcelona, Spain – name: 69 Centre Hospitalier Universitaire de Lille, Epidemiology and Public Health Department, F-59000 Lille, France – name: 40 Departments of Medicine, Geriatrics, Gerontology and Neurology, University of Mississippi Medical Center, Jackson, MS, USA – name: 107 Molecular Genetics Lab-Hospital, University of Central Asturias, Oviedo, Spain, 33011 Oviedo, Spain – name: 45 Department of Geriatric Medicine, Karolinska University Hospital Huddinge, S-14186 Stockholm – name: 57 IdiPAZ, Instituto de Investigación, Sanitaria la Paz, Spain – name: 10 Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA – name: 153 Memory Research and Resources Center, CMRR de Bordeaux, Bordeaux, France – name: 135 Institute of Public Health, University of Cambridge, Cambridge, UK – name: 126 Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington, USA – name: 51 Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA – name: 123 Cambridge Institute for Medical Research, University of Cambridge, UK – name: 11 Dr. John T. Macdonald Foundation, Department of Human Genetics, University of Miami, Miami, Florida, USA – name: 146 Florida Alzheimer’s Disease Research Center, Gainesville, FL, USA – name: 27 Department of Neurology, Kuopio University Hospital, FIN-70211, Kuopio, Finland – name: 128 PharmaTherapeutics Clinical Research, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, USA – name: 39 Brown Foundation Institute of Molecular Medicine, The University of Texas Health Sciences Center at Houston, TX, USA – name: 134 Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany – name: 8 The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA – name: 19 Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona, Spain – name: 154 Neurogenetics Laboratory, Division of Neurosciences, Centre for Applied Medical Research, University of Navarra School of Medicine, Pamplona, Spain – name: 48 Department of Medicine, University of Washington, Seattle, Washington, USA – name: 159 Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA – name: 68 Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, USA – name: 95 University of Pittsburgh, Alzheimer’s Disease Research Center, Pittsburgh, Pennsylvania, USA – name: 102 Department of Family Medicine, University of Washington, Seattle, WA, USA – name: 5 Institut Pasteur de Lille, F-59000 Lille, France – name: 38 Department of Immunology, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria, Spain – name: 86 Experimental Neuropsychiatry Laboratory, IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Rome, Italy – name: 23 Taub Institute on Alzheimer’s Disease and the Aging Brain, Department of Neurology, Columbia University, New York, New York, USA – name: 47 Institute of Genetics, Queens Medical Centre, University of Nottingham, Nottingham, UK – name: 36 Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy – name: 41 Centre hospitalier du Rouvray. 76300 Sotteville les Rouen, France – name: 30 German Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany – name: 42 Inserm U1079, Rouen University, IRIB, Normandy University, Rouen, France – name: 141 3rd Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece – name: 81 Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA – name: 99 Department of Neurology, Albert Einstein College of Medicine, New York, New York, USA – name: 156 Center for Applied Genomics, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA – name: 80 Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Austria – name: 151 INSERM U1061, La Colombière Hospital, Montpellier, France – name: 121 Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA – name: 114 Banner Alzheimer’s Institute, Phoenix, Arizona, USA – name: 82 Department of Psychiatry, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, USA – name: 28 Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Departments of Neurology and Psychiatry, Brigham and Women’s Hospital, Boston, MA – name: 70 Inserm UMR-S1171, CNR-Maj, F-59000 Lille, France – name: 34 Institute for Systems Biology, Seattle, WA, USA – name: 98a Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, USA – name: 152 Montpellier University, Montpellier, France – name: 7 Icelandic Heart Association, Kopavogur, Iceland – name: 3 Department of Biostatistics and Epidemiology/Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA – name: 50 Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queens University, Belfast, UK – name: 74 Department of Psychiatry and Psychotherapy, University of Cologne, 50937 Cologne, Germany – name: 78 National Alzheimer’s Coordinating Center, University of Washington, Seattle, Washington, USA – name: 66 Sorbonne Universités, Université Pierre et Marie Curie, Paris, France – name: 85 Alzheimer’s Disease and Memory Disorders Center, Baylor College of Medicine, Houston, Texas, USA – name: 25 Department of Neurology, Columbia University, New York, New York, USA – name: 88 Department of Epidemiology, University of Washington, Seattle, WA, USA – name: 94 Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA – name: 46 Aging Reasearch Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden – name: 26 Institute of Biom, University of Eastern Finland, FIN-70211, Kuopio, Finland – name: 1 Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, UK – name: 113 Arizona Alzheimer’s Consortium, Phoenix, Arizona, USA – name: 100 Utah State University, Logan, Utah, USA – name: 67 Institut de la Memoire et de la Maladie d’Alzheimer (IM2A) & Institut du Cerveau et de la Moelle épinière (ICM), Département de Neurologie, Hôpital de la Pitié-Salpêtrière, Paris, France |
| Author_xml | – sequence: 5 givenname: Nandini orcidid: 0000-0002-6944-748X surname: Badarinarayan fullname: Badarinarayan, Nandini organization: Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University – sequence: 10 givenname: Joshua C surname: Bis fullname: Bis, Joshua C organization: Department of Medicine, Cardiovascular Health Research Unit, University of Washington – sequence: 13 givenname: Stefanie surname: Heilmann-Heimbach fullname: Heilmann-Heimbach, Stefanie organization: Institute of Human Genetics, University of Bonn, Department of Genomics, Life & Brain Center, University of Bonn – sequence: 16 givenname: Kristel surname: Sleegers fullname: Sleegers, Kristel organization: Department of Molecular Genetics, Neurodegenerative Brain Diseases Group, VIB, Institute Born-Bunge, University of Antwerp – sequence: 17 givenname: Maria surname: Vronskaya fullname: Vronskaya, Maria organization: Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University – sequence: 26 givenname: Charles C surname: White fullname: White, Charles C organization: Departments of Neurology and Psychiatry, Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Brigham and Women's Hospital – sequence: 27 givenname: Kara L surname: Hamilton-Nelson fullname: Hamilton-Nelson, Kara L organization: John P. Hussman Institute for Human Genomics, University of Miami – sequence: 30 givenname: Seung-Hoan surname: Choi fullname: Choi, Seung-Hoan organization: Boston University School of Medicine, Department of Biostatistics, Boston University School of Public Health – sequence: 37 givenname: Andreas J surname: Forstner fullname: Forstner, Andreas J organization: Institute of Human Genetics, University of Bonn, Department of Genomics, Life & Brain Center, University of Bonn – sequence: 40 givenname: Delphine surname: Bacq fullname: Bacq, Delphine organization: CEA/Institut de Génomique, Centre National de Génotypage – sequence: 46 givenname: Jennifer A orcidid: 0000-0001-8509-148X surname: Brody fullname: Brody, Jennifer A organization: Department of Medicine, Cardiovascular Health Research Unit, University of Washington – sequence: 50 givenname: Frank J orcidid: 0000-0003-2226-4050 surname: Wolters fullname: Wolters, Frank J organization: Department of Epidemiology, Erasmus Medical Center – sequence: 54 givenname: Myriam surname: Fornage fullname: Fornage, Myriam organization: Brown Foundation Institute of Molecular Medicine, University of Texas Health Sciences Center at Houston – sequence: 57 givenname: Elisa surname: Majounie fullname: Majounie, Elisa organization: Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University – sequence: 60 givenname: David surname: Wallon fullname: Wallon, David organization: Centre Hospitalier du Rouvray, Sotteville les, INSERM U1079, Rouen University, IRIB, Normandy University – sequence: 61 givenname: Michelle K orcidid: 0000-0002-7274-7299 surname: Lupton fullname: Lupton, Michelle K organization: Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, Genetic Epidemiology, QIMR Berghofer Medical Research Institute – sequence: 66 givenname: Xueqiu surname: Jian fullname: Jian, Xueqiu organization: Brown Foundation Institute of Molecular Medicine, University of Texas Health Sciences Center at Houston – sequence: 67 givenname: Shubhabrata surname: Mukherjee fullname: Mukherjee, Shubhabrata organization: Department of Medicine, University of Washington – sequence: 76 givenname: Vincenzo surname: Solfrizzi fullname: Solfrizzi, Vincenzo organization: Geriatric Medicine–Memory Unit and Rare Disease Centre, University of Bari Aldo Moro – sequence: 79 givenname: Mariet surname: Allen fullname: Allen, Mariet organization: Department of Neuroscience, Mayo Clinic, Jacksonville – sequence: 82 givenname: L Adrienne surname: Cupples fullname: Cupples, L Adrienne organization: Framingham Heart Study, Department of Biostatistics, Boston University School of Public Health – sequence: 89 givenname: Ina surname: Giegling fullname: Giegling, Ina organization: Department of Psychiatry, Martin Luther University Halle-Wittenberg – sequence: 91 givenname: Vilmantas orcidid: 0000-0003-3423-2021 surname: Giedraitis fullname: Giedraitis, Vilmantas organization: Department of Public Health/Geriatrics, Uppsala University – sequence: 94 givenname: Xue surname: Wang fullname: Wang, Xue organization: Department of Neuroscience, Mayo Clinic, Jacksonville – sequence: 96 givenname: Patrizia surname: Mecocci fullname: Mecocci, Patrizia organization: Department of Medicine, Section of Gerontology and Geriatrics, University of Perugia – sequence: 97 givenname: Gudny surname: Eiriksdottir fullname: Eiriksdottir, Gudny organization: Icelandic Heart Association – sequence: 107 givenname: Yuning orcidid: 0000-0002-7358-7055 surname: Chen fullname: Chen, Yuning organization: Department of Biostatistics, Boston University School of Public Health – sequence: 123 givenname: Matthew P surname: Frosch fullname: Frosch, Matthew P organization: C.S. Kubik Laboratory for Neuropathology, Massachusetts General Hospital – sequence: 127 givenname: Ryan M surname: Huebinger fullname: Huebinger, Ryan M organization: Department of Surgery, University of Texas Southwestern Medical Center – sequence: 131 givenname: John surname: Morris fullname: Morris, John organization: Department of Psychiatry, Washington University School of Medicine, Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine – sequence: 132 givenname: Oscar surname: Sotolongo-Grau fullname: Sotolongo-Grau, Oscar organization: Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades – sequence: 133 givenname: Mindy J surname: Katz fullname: Katz, Mindy J organization: Department of Neurology, Albert Einstein College of Medicine – sequence: 136 givenname: Amy surname: Braddel fullname: Braddel, Amy organization: Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University – sequence: 141 givenname: Jade surname: Chapman fullname: Chapman, Jade organization: Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University – sequence: 144 givenname: Matt surname: Hill fullname: Hill, Matt organization: Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University – sequence: 147 givenname: Bruno surname: Vellas fullname: Vellas, Bruno organization: INSERM U558, University of Toulouse – sequence: 148 givenname: Hilkka surname: Soininen fullname: Soininen, Hilkka organization: Department of Neurology, Kuopio University Hospital – sequence: 153 givenname: Joseph T surname: Hughes fullname: Hughes, Joseph T organization: Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London – sequence: 165 givenname: Manuel surname: Mayhaus fullname: Mayhaus, Manuel organization: Department of Psychiatry and Psychotherapy, University Hospital – sequence: 173 givenname: Raffaele Giovanni surname: Maletta fullname: Maletta, Raffaele Giovanni organization: Regional Neurogenetic Centre (CRN), ASP Catanzaro – sequence: 174 givenname: David surname: Carrell fullname: Carrell, David organization: Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine – sequence: 178 givenname: Alberto surname: Pilotto fullname: Pilotto, Alberto organization: Department of Medical Sciences, Geriatric Unit and Gerontology–Geriatrics Research Laboratory, IRCCS Casa Sollievo della Sofferenza – sequence: 187 givenname: Nick C surname: Fox fullname: Fox, Nick C organization: Department of Molecular Neuroscience, UCL, Institute of Neurology – sequence: 192 givenname: Steven E surname: Arnold fullname: Arnold, Steven E organization: Department of Psychiatry, University of Pennsylvania Perelman School of Medicine – sequence: 199 givenname: James T surname: Becker fullname: Becker, James T organization: Departments of Psychiatry, Neurology, and Psychology, University of Pittsburgh School of Medicine – sequence: 205 givenname: James R surname: Burke fullname: Burke, James R organization: Department of Medicine, Duke University – sequence: 211 givenname: Cynthia M surname: Carlsson fullname: Carlsson, Cynthia M organization: Department of Medicine, University of Wisconsin, Wisconsin Alzheimer's Disease Research Center – sequence: 217 givenname: David G surname: Clark fullname: Clark, David G organization: Department of Neurology, Medical University of South Carolina, Department of Neurology, Ralph H. Johnson VA Medical Center – sequence: 218 givenname: David H surname: Cribbs fullname: Cribbs, David H organization: Department of Neurology, University of California, Irvine – sequence: 222 givenname: Ranjan surname: Duara fullname: Duara, Ranjan organization: Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center – sequence: 223 givenname: Denis A surname: Evans fullname: Evans, Denis A organization: Department of Internal Medicine, Rush Institute for Healthy Aging, Rush University Medical Center – sequence: 225 givenname: Kenneth B surname: Fallon fullname: Fallon, Kenneth B organization: Department of Pathology, University of Alabama at Birmingham – sequence: 227 givenname: Martin R surname: Farlow fullname: Farlow, Martin R organization: Department of Neurology, Indiana University – sequence: 229 givenname: Tatiana M surname: Foroud fullname: Foroud, Tatiana M organization: Department of Medical and Molecular Genetics, Indiana University – sequence: 230 givenname: Douglas R surname: Galasko fullname: Galasko, Douglas R organization: Department of Neurosciences, University of California – sequence: 245 givenname: Lee-Way surname: Jin fullname: Jin, Lee-Way organization: Department of Pathology and Laboratory Medicine, University of California, Davis – sequence: 253 givenname: James J surname: Lah fullname: Lah, James J organization: Department of Neurology, Emory University – sequence: 255 givenname: Allan I surname: Levey fullname: Levey, Allan I organization: Department of Neurology, Emory University – sequence: 257 givenname: Andrew P surname: Lieberman fullname: Lieberman, Andrew P organization: Department of Pathology, University of Michigan – sequence: 267 givenname: Ann C surname: McKee fullname: McKee, Ann C organization: Department of Neurology, Boston University, Department of Pathology, Boston University – sequence: 272 givenname: John C surname: Morris fullname: Morris, John C organization: Department of Pathology and Immunology, Washington University, Department of Neurology, Washington University – sequence: 279 givenname: Henry L surname: Paulson fullname: Paulson, Henry L organization: Department of Neurology, University of Michigan, Michigan Alzheimer Disease Center – sequence: 281 givenname: Elaine surname: Peskind fullname: Peskind, Elaine organization: Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine – sequence: 285 givenname: Joseph F surname: Quinn fullname: Quinn, Joseph F organization: Department of Neurology, Oregon Health & Science University, Department of Neurology, Portland Veterans Affairs Medical Center – sequence: 287 givenname: Murray surname: Raskind fullname: Raskind, Murray organization: Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine – sequence: 302 givenname: Salvatore surname: Spina fullname: Spina, Salvatore organization: Department of Pathology and Laboratory Medicine, Indiana University – sequence: 304 givenname: Russell H surname: Swerdlow fullname: Swerdlow, Russell H organization: University of Kansas Alzheimer's Disease Center, University of Kansas Medical Center – sequence: 310 givenname: Linda J surname: Van Eldik fullname: Van Eldik, Linda J organization: Department of Anatomy and Neurobiology, Sanders-Brown Center on Aging, University of Kentucky – sequence: 311 givenname: Harry V surname: Vinters fullname: Vinters, Harry V organization: Department of Neurology, University of California, Los Angeles, Department of Pathology and Laboratory Medicine, University of California, Los Angeles – sequence: 312 givenname: Jean Paul surname: Vonsattel fullname: Vonsattel, Jean Paul organization: Department of Pathology, Taub Institute on Alzheimer's Disease and the Aging Brain, Columbia University – sequence: 327 givenname: Peter P surname: De Deyn fullname: De Deyn, Peter P organization: Institute Born-Bunge, University of Antwerp, Department of Neurology and Memory Clinic, Hospital Network Antwerp – sequence: 336 givenname: Letizia surname: Concari fullname: Concari, Letizia organization: Department of Neuroscience, University of Parma, Center for Cognitive Disorders AUSL – sequence: 344 givenname: Alexis surname: Brice fullname: Brice, Alexis organization: INSERM U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Université Paris 06, UMRS 1127, Institut du Cerveau et de la Moelle Épinière, Department of Genetics, AP–HP, Pitié-Salpêtrière Hospital – sequence: 346 givenname: Bruno surname: Dubois fullname: Dubois, Bruno organization: Département de Neurologie, Institut de la Mémoire et de la Maladie d'Alzheimer (IM2A), Hôpital de la Pitié-Salpêtrière, AP–HP, Institut des Neurosciences Translationnelles de Paris (IHU-A-ICM), Institut du Cerveau et de la Moelle Épinière (ICM), INSERM, CNRS, UMRS 975, Institut du Cerveau et de la Moelle Épinière (ICM), Sorbonne Universités, Université Pierre et Marie Curie, Hôpital de la Pitié-Salpêtrière, AP–HP – sequence: 349 givenname: JoAnn surname: Tschanz fullname: Tschanz, JoAnn organization: Department of Mathematics and Statistics, Utah State University – sequence: 350 givenname: Annette L surname: Fitzpatrick fullname: Fitzpatrick, Annette L organization: Department of Epidemiology, University of Washington, Department of Family Medicine, University of Washington – sequence: 351 givenname: Walter A surname: Kukull fullname: Kukull, Walter A organization: Department of Epidemiology, University of Washington – sequence: 358 givenname: María J orcidid: 0000-0002-6477-1117 surname: Bullido fullname: Bullido, María J organization: Instituto de Investigación Sanitaria Hospital la Paz (IdiPAZ), Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Centro de Biología Molecular Severo Ochoa (CSIC-UAM) – sequence: 361 givenname: Eliecer surname: Coto fullname: Coto, Eliecer organization: Molecular Genetics Laboratory-Hospital, University of Central Asturias – sequence: 366 givenname: Eric M surname: Reiman fullname: Reiman, Eric M organization: Neurogenomics Division, Translational Genomics Research Institute, Arizona Alzheimer's Consortium, Banner Alzheimer's Institute, Department of Psychiatry, University of Arizona – sequence: 367 givenname: Maura surname: Gallo fullname: Gallo, Maura organization: Regional Neurogenetic Centre (CRN), ASP Catanzaro – sequence: 376 givenname: Elio surname: Scarpini fullname: Scarpini, Elio organization: Department of Pathophysiology and Transplantation, University of Milan, Fondazione Ca' Granda, IRCCS Ospedale Policlinico – sequence: 377 givenname: Debby W surname: Tsuang fullname: Tsuang, Debby W organization: Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, VA Puget Sound Health Care System/GRECC – sequence: 379 givenname: Ubaldo surname: Bonuccelli fullname: Bonuccelli, Ubaldo organization: Department of Experimental and Clinical Medicine, Neurological Institute, University of Pisa – sequence: 389 givenname: David C orcidid: 0000-0001-5002-5263 surname: Rubinsztein fullname: Rubinsztein, David C organization: Cambridge Institute for Medical Research, University of Cambridge – sequence: 390 givenname: Jose surname: Bras fullname: Bras, Jose organization: Department of Molecular Neuroscience, UCL, Institute of Neurology, Department of Medical Sciences, Institute of Biomedicine (iBiMED), University of Aveiro – sequence: 391 givenname: Rita surname: Guerreiro fullname: Guerreiro, Rita organization: Department of Molecular Neuroscience, UCL, Institute of Neurology, Department of Medical Sciences, Institute of Biomedicine (iBiMED), University of Aveiro – sequence: 399 givenname: Simon surname: Lovestone fullname: Lovestone, Simon organization: Department of Psychiatry, University of Oxford – sequence: 401 givenname: Michael J surname: Owen fullname: Owen, Michael J organization: Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University – sequence: 407 givenname: Carlos surname: Cruchaga fullname: Cruchaga, Carlos organization: Department of Psychiatry, Washington University School of Medicine, Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine – sequence: 410 givenname: John surname: Powell fullname: Powell, John organization: Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London – sequence: 413 givenname: Philip L orcidid: 0000-0002-8057-2505 surname: De Jager fullname: De Jager, Philip L organization: Department of Neurology, Center for Translational and Systems Neuroimmunology, Columbia University Medical Center – sequence: 422 givenname: Dan surname: Rujescu fullname: Rujescu, Dan organization: Department of Psychiatry, Martin Luther University Halle-Wittenberg – sequence: 426 givenname: Sara surname: Ortega-Cubero fullname: Ortega-Cubero, Sara organization: Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Division of Neurosciences, Neurogenetics Laboratory, Centre for Applied Medical Research, University of Navarra School of Medicine, Department of Neurology, Complejo Asistencial Universitario de Palencia – sequence: 433 givenname: M Arfan orcidid: 0000-0003-0372-8585 surname: Ikram fullname: Ikram, M Arfan organization: Department of Epidemiology, Erasmus Medical Center, Department of Neurology, Erasmus MC University Medical Center – sequence: 439 givenname: Richard surname: Mayeux fullname: Mayeux, Richard organization: Department of Neurology, Taub Institute on Alzheimer's Disease and the Aging Brain, Columbia University, Gertrude H. Sergievsky Center, Columbia University, Department of Neurology, Columbia University – sequence: 440 givenname: Jean-François surname: Deleuze fullname: Deleuze, Jean-François organization: CEA/Institut de Génomique, Centre National de Génotypage – sequence: 441 givenname: Najaf surname: Amin fullname: Amin, Najaf organization: Department of Epidemiology, Erasmus Medical Center – sequence: 444 givenname: Philippe orcidid: 0000-0001-9088-234X surname: Amouyel fullname: Amouyel, Philippe organization: INSERM, U1167, RID-AGE–Risk Factors and Molecular Determinants of Aging-Related Diseases, Institut Pasteur de Lille, University Lille, U1167–Excellence Laboratory LabEx DISTALZ, Epidemiology and Public Health Department, Centre Hospitalier Universitaire de Lille – sequence: 445 givenname: Cornelia M surname: van Duijn fullname: van Duijn, Cornelia M organization: Department of Epidemiology, Erasmus Medical Center |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28714976$$D View this record in MEDLINE/PubMed https://inserm.hal.science/inserm-02466466$$DView record in HAL https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-147014$$DView record from Swedish Publication Index https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-334927$$DView record from Swedish Publication Index http://kipublications.ki.se/Default.aspx?queryparsed=id:136541668$$DView record from Swedish Publication Index |
| BookMark | eNqNk91u1DAQhSNURH9AvAGKxEVBahbbcZz4ptJSSltpUVEpvbVcZ5K6JM5iJ4Xy9Ey0y7ZbFalKoljj78yMjsfb0YbrHETRa0omlKTFB1dPUknFs2iLZlwkNKfFBq6JoAknqdiMtkO4JoRyTooX0SYrcsplLraicKY9xKYrravjG-2tdn2IrYu_zg6O2F48_XiS7sXalfH52eEXFtt23lije4hba3xXN1Y3SQulxVCJOjdu2bYdnO1vxzzT5s8V2Bb8bohLG0AHeBk9r3QT4NXyvxN9_3x4fnCczE6PTg6ms8Rgd31iypzoMjdcswpELrFpVhgoSsmrgkrBjSaa4VcJRo28zGWVywwuUzB5aXSV7kTJIm_4BfPhUs29bbW_VZ22ahn6gStQXGapTJHf-y__yV5MVedrNQwqTblk-dPwMCjKczQe8f0FjiwaZsD1XjdrqvUdZ69U3d2oTAhJsL9VvasHsuPpTFkXwLeKMC4EvjcU8XfLer77OUDoVWuDgabRDrohKCoZoZJnbGzt7QP0uhu8w7NBKi1Ilom8uKNq3QAWrDps04xJ1TQjDF0pmEBq8giFTwk4MTi1lcX4muD9mgCZHn73tR5CUCffzp7Onl6ss2_u-71y7N_sI7C7AHCOQ_BQrRBK1HirlKvVeKvuBmlFGtvr3nbjQdnmEX5pfcCMrgZ_z88H6F-ZfC10 |
| CitedBy_id | crossref_primary_10_1016_j_jaci_2023_08_036 crossref_primary_10_1007_s00401_018_1932_x crossref_primary_10_1002_glia_23558 crossref_primary_10_1002_humu_23872 crossref_primary_10_1186_s40478_019_0795_2 crossref_primary_10_1186_s12974_024_03271_9 crossref_primary_10_1038_s41467_021_21823_y crossref_primary_10_1186_s13073_022_01035_9 crossref_primary_10_1016_j_pneurobio_2018_09_007 crossref_primary_10_1001_jamaneurol_2019_1456 crossref_primary_10_1038_s41582_025_01062_1 crossref_primary_10_1038_s10038_021_00987_x crossref_primary_10_1186_s12974_024_03163_y crossref_primary_10_1083_jcb_201709069 crossref_primary_10_1111_bpa_12882 crossref_primary_10_1016_j_tjpad_2024_100025 crossref_primary_10_1016_j_trci_2019_09_005 crossref_primary_10_1038_s41380_023_02076_1 crossref_primary_10_1093_schbul_sby080 crossref_primary_10_1109_JBHI_2020_2973324 crossref_primary_10_3389_fnagi_2023_1264448 crossref_primary_10_1007_s12038_021_00217_8 crossref_primary_10_1093_brain_awae090 crossref_primary_10_1002_glia_23781 crossref_primary_10_1016_j_str_2021_10_009 crossref_primary_10_1038_s41591_025_03494_0 crossref_primary_10_1186_s13041_019_0504_x crossref_primary_10_1093_hmg_ddz320 crossref_primary_10_1007_s00401_018_1822_2 crossref_primary_10_1186_s12883_023_03503_0 crossref_primary_10_1016_j_nbd_2018_07_003 crossref_primary_10_1016_j_arr_2021_101336 crossref_primary_10_1186_s13195_021_00884_7 crossref_primary_10_1186_s40478_020_0879_z crossref_primary_10_1016_j_nbd_2020_104946 crossref_primary_10_1126_sciadv_adn6037 crossref_primary_10_3233_JAD_190342 crossref_primary_10_1038_s41598_018_23155_2 crossref_primary_10_1186_s13024_021_00505_9 crossref_primary_10_3233_JAD_221070 crossref_primary_10_1002_ana_25530 crossref_primary_10_1016_j_neubiorev_2021_11_009 crossref_primary_10_1002_ibra_12021 crossref_primary_10_1038_s41589_018_0155_8 crossref_primary_10_1093_mutage_geae029 crossref_primary_10_1002_glia_24628 crossref_primary_10_1038_s41598_022_09825_2 crossref_primary_10_1097_WCO_0000000000000729 crossref_primary_10_1016_j_pneurobio_2020_101971 crossref_primary_10_1590_1980_5764_dn_2022_0025 crossref_primary_10_1016_j_dadm_2018_08_008 crossref_primary_10_1016_j_it_2020_07_006 crossref_primary_10_3233_JAD_190568 crossref_primary_10_1001_jamaneurol_2020_3536 crossref_primary_10_1126_scitranslmed_adk3434 crossref_primary_10_1038_mp_2017_246 crossref_primary_10_1038_s41590_023_01475_4 crossref_primary_10_1002_stem_3309 crossref_primary_10_1016_j_arr_2021_101346 crossref_primary_10_1177_15333175241243183 crossref_primary_10_31083_j_jin2104105 crossref_primary_10_3233_JAD_215635 crossref_primary_10_3390_antiox13101208 crossref_primary_10_1084_jem_20230180 crossref_primary_10_1038_s41590_018_0212_1 crossref_primary_10_1038_s41398_021_01677_0 crossref_primary_10_3390_molecules23051143 crossref_primary_10_1038_s41467_020_19622_y crossref_primary_10_1016_j_neuroscience_2022_05_006 crossref_primary_10_1016_j_xgen_2023_100383 crossref_primary_10_1038_nri_2017_125 crossref_primary_10_1093_hmg_ddy139 crossref_primary_10_3389_fnagi_2023_1290657 crossref_primary_10_3390_ijms241612799 crossref_primary_10_1016_j_sjbs_2022_02_002 crossref_primary_10_1016_j_mad_2021_111438 crossref_primary_10_1038_s41467_021_27204_9 crossref_primary_10_1007_s11011_021_00754_z crossref_primary_10_1016_j_ejcb_2022_151244 crossref_primary_10_1016_j_neuron_2019_02_027 crossref_primary_10_3233_JAD_200019 crossref_primary_10_3389_fcell_2021_683459 crossref_primary_10_1016_j_bbadis_2023_166978 crossref_primary_10_1016_j_jalz_2019_09_004 crossref_primary_10_3389_fnagi_2018_00395 crossref_primary_10_3389_fnagi_2018_00155 crossref_primary_10_1016_j_isci_2024_110546 crossref_primary_10_1038_s42003_025_07594_y crossref_primary_10_1016_j_neurot_2025_e00536 crossref_primary_10_1016_j_gendis_2021_05_001 crossref_primary_10_1186_s13024_023_00674_9 crossref_primary_10_1038_s41583_019_0240_3 crossref_primary_10_1177_1073110518804230 crossref_primary_10_1007_s00401_019_02017_9 crossref_primary_10_1186_s13195_022_01044_1 crossref_primary_10_1167_iovs_19_27827 crossref_primary_10_1038_s41380_024_02838_5 crossref_primary_10_1038_s41421_024_00666_z crossref_primary_10_1016_j_nbd_2021_105272 crossref_primary_10_1038_s41593_020_0650_6 crossref_primary_10_1186_s13148_020_00913_6 crossref_primary_10_1016_j_arr_2021_101409 crossref_primary_10_3390_ph14090930 crossref_primary_10_1186_s13195_019_0469_0 crossref_primary_10_3233_JAD_210480 crossref_primary_10_1002_alz_13502 crossref_primary_10_3389_fimmu_2020_617860 crossref_primary_10_1016_j_tig_2018_02_007 crossref_primary_10_1242_jcs_260638 crossref_primary_10_3389_fgene_2018_00540 crossref_primary_10_1016_j_neuron_2022_10_015 crossref_primary_10_1016_j_jalz_2018_08_013 crossref_primary_10_1097_WAD_0000000000000339 crossref_primary_10_1016_j_ebiom_2019_102607 crossref_primary_10_1186_s12974_024_03208_2 crossref_primary_10_3389_fnagi_2023_1161405 crossref_primary_10_1007_s00401_020_02138_6 crossref_primary_10_1007_s10557_021_07175_1 crossref_primary_10_3389_fgene_2021_748781 crossref_primary_10_3389_fphar_2019_01008 crossref_primary_10_1002_cpsc_122 crossref_primary_10_1186_s12974_019_1661_7 crossref_primary_10_1016_j_celrep_2020_107843 crossref_primary_10_5582_irdr_2017_01073 crossref_primary_10_1016_S1474_4422_19_30435_1 crossref_primary_10_2174_1567205017666200212155234 crossref_primary_10_3390_genes12030443 crossref_primary_10_1007_s12035_020_01894_6 crossref_primary_10_1016_j_arr_2020_101114 crossref_primary_10_1093_gerona_glae185 crossref_primary_10_1002_dad2_12229 crossref_primary_10_1186_s13024_023_00599_3 crossref_primary_10_1038_s41398_024_03058_9 crossref_primary_10_3233_JAD_180107 crossref_primary_10_3390_cells9061406 crossref_primary_10_1016_j_neulet_2019_01_043 crossref_primary_10_3389_fpsyt_2020_00255 crossref_primary_10_1016_j_jalz_2018_07_217 crossref_primary_10_1016_j_neurobiolaging_2017_12_008 crossref_primary_10_1080_19490976_2020_1854967 crossref_primary_10_1007_s13311_021_01152_0 crossref_primary_10_1186_s41983_021_00420_2 crossref_primary_10_1038_s41398_020_01145_1 crossref_primary_10_1038_s41593_020_0599_5 crossref_primary_10_1016_j_neurobiolaging_2017_12_002 crossref_primary_10_1039_D3MD00096F crossref_primary_10_1038_s41590_023_01473_6 crossref_primary_10_1523_JNEUROSCI_1483_21_2021 crossref_primary_10_1016_j_immuni_2021_12_013 crossref_primary_10_1186_s13024_022_00523_1 crossref_primary_10_1172_JCI97509 crossref_primary_10_3389_fnmol_2020_00151 crossref_primary_10_1371_journal_pone_0281440 crossref_primary_10_1210_endrev_bnac001 crossref_primary_10_3233_JAD_180433 crossref_primary_10_1186_s40478_021_01261_z crossref_primary_10_1016_j_autrev_2018_04_001 crossref_primary_10_1038_s41380_021_01249_0 crossref_primary_10_1038_s41467_023_38374_z crossref_primary_10_3390_genes13010039 crossref_primary_10_1186_s13073_023_01160_z crossref_primary_10_1016_j_neurobiolaging_2018_08_016 crossref_primary_10_1016_j_preteyeres_2020_100899 crossref_primary_10_2174_1567205018666211105140732 crossref_primary_10_1073_pnas_2112971118 crossref_primary_10_1016_j_arr_2023_101916 crossref_primary_10_1186_s13024_018_0298_9 crossref_primary_10_18632_aging_102645 crossref_primary_10_3389_fnins_2020_00228 crossref_primary_10_1016_j_addr_2022_114398 crossref_primary_10_1016_j_neurobiolaging_2018_10_028 crossref_primary_10_1038_s41531_021_00213_7 crossref_primary_10_3390_cells12232672 crossref_primary_10_3389_fphar_2018_00867 crossref_primary_10_1186_s13073_022_01136_5 crossref_primary_10_1038_s41398_019_0394_9 crossref_primary_10_2174_1871527321666220417005115 crossref_primary_10_18632_aging_104172 crossref_primary_10_1002_gepi_22133 crossref_primary_10_1186_s13072_018_0211_3 crossref_primary_10_1016_j_neurobiolaging_2017_12_027 crossref_primary_10_1186_s13073_021_00878_y crossref_primary_10_3389_fphys_2020_00683 crossref_primary_10_1002_ctm2_1332 crossref_primary_10_3389_fnins_2018_00605 crossref_primary_10_1016_j_neurobiolaging_2022_03_001 crossref_primary_10_1093_nsr_nwy127 crossref_primary_10_1159_000501935 crossref_primary_10_3389_fncel_2024_1317125 crossref_primary_10_1016_j_neuron_2023_05_031 crossref_primary_10_1177_13872877251317543 crossref_primary_10_1002_alz_12212 crossref_primary_10_1002_alz_12577 crossref_primary_10_1186_s13024_022_00542_y crossref_primary_10_1126_science_abb8575 crossref_primary_10_1093_bib_bbab522 crossref_primary_10_26508_lsa_202302181 crossref_primary_10_3390_genes12030419 crossref_primary_10_1186_s13024_022_00588_y crossref_primary_10_1186_s13195_023_01362_y crossref_primary_10_3389_fnagi_2024_1511437 crossref_primary_10_1007_s12035_024_04126_3 crossref_primary_10_2174_1567205016666190321154618 crossref_primary_10_1371_journal_pone_0288497 crossref_primary_10_1093_braincomms_fcab083 crossref_primary_10_1186_s13024_021_00436_5 crossref_primary_10_1007_s00894_023_05770_7 crossref_primary_10_1038_s41593_018_0296_9 crossref_primary_10_1007_s00401_019_02004_0 crossref_primary_10_1038_s41598_021_96144_7 crossref_primary_10_1002_alz_13427 crossref_primary_10_1186_s13024_023_00604_9 crossref_primary_10_1097_WAD_0000000000000530 crossref_primary_10_1038_s41582_023_00789_z crossref_primary_10_3389_fnins_2018_00963 crossref_primary_10_1002_humu_23904 crossref_primary_10_1002_alz_12106 crossref_primary_10_1016_j_fmre_2023_02_025 crossref_primary_10_1186_s12974_025_03387_6 crossref_primary_10_1007_s00401_020_02200_3 crossref_primary_10_7554_eLife_51700 crossref_primary_10_1093_gerona_glab030 crossref_primary_10_1055_s_0040_1713631 crossref_primary_10_1186_s13024_021_00449_0 crossref_primary_10_3390_ijms21124516 crossref_primary_10_1038_s41593_019_0539_4 crossref_primary_10_15252_emmm_201809027 crossref_primary_10_3390_ijms23158714 crossref_primary_10_1002_glia_24461 crossref_primary_10_3233_JAD_220025 crossref_primary_10_3389_fnagi_2022_858429 crossref_primary_10_3389_fnins_2018_00627 crossref_primary_10_7554_eLife_54083 crossref_primary_10_1007_s00406_020_01179_y crossref_primary_10_1016_j_jalz_2019_06_4950 crossref_primary_10_1016_j_neurol_2023_12_006 crossref_primary_10_1038_s41541_018_0046_8 crossref_primary_10_1126_sciadv_abd5575 crossref_primary_10_1021_acsnano_3c09311 crossref_primary_10_3233_JAD_190153 crossref_primary_10_1007_s12035_023_03553_y crossref_primary_10_1038_s41380_018_0255_6 crossref_primary_10_3233_JAD_210207 crossref_primary_10_1016_S0140_6736_20_32205_4 crossref_primary_10_1186_s12967_023_04835_8 crossref_primary_10_4049_jimmunol_1901068 crossref_primary_10_1002_alz_12319 crossref_primary_10_1371_journal_pgen_1009398 crossref_primary_10_3390_biology12121529 crossref_primary_10_1126_sciadv_abp9688 crossref_primary_10_3389_fnins_2023_1195724 crossref_primary_10_7717_peerj_8324 crossref_primary_10_1016_j_celrep_2019_03_099 crossref_primary_10_1093_brain_awaa425 crossref_primary_10_1016_j_neuroimage_2021_118304 crossref_primary_10_1080_10409238_2018_1458070 crossref_primary_10_1007_s00401_022_02495_4 crossref_primary_10_1038_s41467_022_34679_7 crossref_primary_10_1186_s13073_023_01155_w crossref_primary_10_1016_j_it_2020_02_002 crossref_primary_10_1007_s40142_019_0161_5 crossref_primary_10_1093_braincomms_fcz022 crossref_primary_10_1002_alz_12680 crossref_primary_10_3389_fnagi_2018_00314 crossref_primary_10_1016_j_jbior_2024_101053 crossref_primary_10_3390_ijms22189865 crossref_primary_10_3389_fneur_2021_679927 crossref_primary_10_3233_JAD_220680 crossref_primary_10_1002_art_41704 crossref_primary_10_3389_fimmu_2019_01768 crossref_primary_10_3390_genes12081247 crossref_primary_10_18632_oncotarget_26173 crossref_primary_10_3390_ijms241210106 crossref_primary_10_3389_fnmol_2017_00421 crossref_primary_10_1016_j_dadm_2019_03_005 crossref_primary_10_3389_fncel_2018_00313 crossref_primary_10_1016_j_nbas_2023_100081 crossref_primary_10_1038_s41598_019_38793_3 crossref_primary_10_3390_math11061529 crossref_primary_10_3390_genes12121990 crossref_primary_10_1186_s13024_018_0296_y crossref_primary_10_1007_s00401_019_02048_2 crossref_primary_10_1007_s12031_024_02212_8 crossref_primary_10_1002_glia_24311 crossref_primary_10_1002_alz_14444 crossref_primary_10_1186_s13195_018_0435_2 crossref_primary_10_1042_CS20171634 crossref_primary_10_3233_JAD_181038 crossref_primary_10_1002_alz_12389 crossref_primary_10_1093_brain_awab337 crossref_primary_10_1016_j_intimp_2022_108733 crossref_primary_10_1038_s43587_021_00108_5 crossref_primary_10_1016_j_coph_2021_11_008 crossref_primary_10_1186_s13024_020_00402_7 crossref_primary_10_1186_s13024_018_0282_4 crossref_primary_10_1080_15592294_2023_2241008 crossref_primary_10_1038_s41590_018_0241_9 crossref_primary_10_3233_JAD_231318 crossref_primary_10_1186_s12979_023_00366_4 crossref_primary_10_1002_alz_13439 crossref_primary_10_1038_s41588_020_00776_w crossref_primary_10_1016_j_tins_2023_03_005 crossref_primary_10_1007_s10787_024_01550_8 crossref_primary_10_3389_fnagi_2021_753210 crossref_primary_10_1038_s41431_018_0273_5 crossref_primary_10_1016_j_neuron_2018_10_031 crossref_primary_10_1038_s41598_017_17999_3 crossref_primary_10_1186_s12974_019_1412_9 crossref_primary_10_1016_j_arr_2024_102596 crossref_primary_10_1038_s41435_020_00113_5 crossref_primary_10_1016_j_biopsych_2017_05_014 crossref_primary_10_1186_s13024_022_00589_x crossref_primary_10_3389_fnagi_2022_935279 crossref_primary_10_7554_eLife_88492 crossref_primary_10_1007_s00401_019_02026_8 crossref_primary_10_1186_s13073_022_01022_0 crossref_primary_10_1097_WCO_0000000000000911 crossref_primary_10_1007_s10571_021_01147_7 crossref_primary_10_1371_journal_pone_0185777 crossref_primary_10_1016_j_nbd_2020_104976 crossref_primary_10_1007_s13311_022_01201_2 crossref_primary_10_1038_s41588_020_0596_3 crossref_primary_10_2174_1574885518666230427100702 crossref_primary_10_1016_j_neuron_2024_04_009 crossref_primary_10_1002_glia_24652 crossref_primary_10_1007_s40484_020_0209_2 crossref_primary_10_1126_sciadv_abm5667 crossref_primary_10_4103_1673_5374_353484 crossref_primary_10_3389_fimmu_2018_00586 crossref_primary_10_3390_cells10102581 crossref_primary_10_1186_s13024_024_00725_9 crossref_primary_10_1186_s12974_018_1180_y crossref_primary_10_1016_j_ynstr_2018_05_003 crossref_primary_10_1038_s41398_020_01018_7 crossref_primary_10_1016_j_str_2021_06_010 crossref_primary_10_1016_j_jalz_2018_06_2857 crossref_primary_10_1155_2021_1683981 crossref_primary_10_3389_fncel_2021_652593 crossref_primary_10_1098_rsob_210280 crossref_primary_10_1038_s41588_023_01392_0 crossref_primary_10_1111_bph_14581 crossref_primary_10_3389_fnins_2018_00209 crossref_primary_10_3389_fnhum_2022_838692 crossref_primary_10_3233_JAD_220755 crossref_primary_10_3389_fnins_2018_00699 crossref_primary_10_33218_prnano1_2__180724_2 crossref_primary_10_1038_s41380_019_0617_8 crossref_primary_10_3233_JAD_215055 crossref_primary_10_1016_j_brainres_2018_11_042 crossref_primary_10_3233_JAD_215174 crossref_primary_10_1038_s41573_020_0065_9 crossref_primary_10_1186_s13024_020_00415_2 crossref_primary_10_3390_brainsci12081057 crossref_primary_10_3390_genes13091607 crossref_primary_10_1038_s41598_023_29108_8 crossref_primary_10_1016_j_nbd_2020_105247 crossref_primary_10_1186_s13024_025_00812_5 crossref_primary_10_1016_j_stemcr_2018_03_003 crossref_primary_10_3389_fimmu_2018_00405 crossref_primary_10_1038_s41467_020_19791_w crossref_primary_10_1016_S1474_4422_23_00247_8 crossref_primary_10_15252_embj_2020105603 crossref_primary_10_1016_j_ajhg_2022_01_005 crossref_primary_10_1038_s41467_020_19737_2 crossref_primary_10_1073_pnas_1715554115 crossref_primary_10_1111_acel_13606 crossref_primary_10_1016_j_neurobiolaging_2018_04_019 crossref_primary_10_1186_s12974_022_02584_x crossref_primary_10_1016_j_bbih_2024_100899 crossref_primary_10_1371_journal_pone_0241552 crossref_primary_10_3389_fnins_2021_667614 crossref_primary_10_1186_s13024_024_00719_7 crossref_primary_10_1016_j_freeradbiomed_2021_08_230 crossref_primary_10_1038_s41588_019_0358_2 crossref_primary_10_1093_bioinformatics_btac033 crossref_primary_10_1093_hmg_ddaa209 crossref_primary_10_1016_j_biopha_2023_115218 crossref_primary_10_1186_s12974_022_02604_w crossref_primary_10_3389_fcell_2021_668738 crossref_primary_10_1093_bioinformatics_bty187 crossref_primary_10_3390_proteomes6040046 crossref_primary_10_1111_acel_12964 crossref_primary_10_1002_alz_12396 crossref_primary_10_1002_alz_12157 crossref_primary_10_1002_alz_12399 crossref_primary_10_1038_s41588_025_02099_0 crossref_primary_10_1038_s41576_018_0018_x crossref_primary_10_1038_s41593_022_01240_0 crossref_primary_10_56083_RCV2N3_001 crossref_primary_10_1093_jnen_nlae083 crossref_primary_10_1371_journal_pone_0299541 crossref_primary_10_1093_brain_awac451 crossref_primary_10_1038_s41467_019_09118_9 crossref_primary_10_1038_s41588_022_01024_z crossref_primary_10_3389_fnagi_2022_896852 crossref_primary_10_3390_cells12242824 crossref_primary_10_1038_s41593_022_01024_6 crossref_primary_10_3389_fmed_2023_1164305 crossref_primary_10_1016_j_neuron_2018_02_002 crossref_primary_10_1016_j_molmed_2024_04_016 crossref_primary_10_3390_vaccines10060943 crossref_primary_10_1007_s11055_023_01484_8 crossref_primary_10_1016_j_sbi_2024_102776 crossref_primary_10_1002_alz_13370 crossref_primary_10_18502_wkmj_v65i4_14677 crossref_primary_10_1172_JCI177793 crossref_primary_10_1016_j_isci_2019_07_023 crossref_primary_10_1016_j_jbc_2025_108356 crossref_primary_10_3389_fnins_2021_742065 crossref_primary_10_1186_s12974_022_02580_1 crossref_primary_10_1016_j_jbc_2021_100905 crossref_primary_10_1177_02698811221122008 crossref_primary_10_1177_10738584211024531 crossref_primary_10_1186_s13024_021_00488_7 crossref_primary_10_1371_journal_pone_0218111 crossref_primary_10_1186_s13024_025_00803_6 crossref_primary_10_1186_s12974_021_02355_0 crossref_primary_10_3389_fimmu_2022_834424 crossref_primary_10_1016_j_neuropharm_2020_108014 crossref_primary_10_1007_s00401_022_02454_z crossref_primary_10_1002_alz_12099 crossref_primary_10_1186_s11658_023_00504_2 crossref_primary_10_1016_j_nbd_2023_106082 crossref_primary_10_1038_s41598_018_37715_z crossref_primary_10_1038_s41582_018_0072_1 crossref_primary_10_1038_s41467_020_17405_z crossref_primary_10_1007_s40588_021_00168_6 crossref_primary_10_1016_j_bj_2018_01_003 crossref_primary_10_1016_j_pharmthera_2019_03_005 crossref_primary_10_3390_ijms20010081 crossref_primary_10_1007_s11825_018_0193_3 crossref_primary_10_3233_JAD_179914 crossref_primary_10_1016_j_neurobiolaging_2022_12_014 crossref_primary_10_1038_s41380_020_0731_7 crossref_primary_10_1038_s41398_021_01362_2 crossref_primary_10_1016_j_lfs_2023_121920 crossref_primary_10_1016_j_ebiom_2020_102919 crossref_primary_10_3389_fnins_2021_666958 crossref_primary_10_1186_s13195_022_01018_3 crossref_primary_10_1038_s41380_022_01637_0 crossref_primary_10_1097_JBR_0000000000000046 crossref_primary_10_1111_bpa_13122 crossref_primary_10_1002_alz_14045 crossref_primary_10_1007_s12035_025_04820_w crossref_primary_10_1080_01621459_2023_2297467 crossref_primary_10_3389_fphar_2019_00840 crossref_primary_10_3390_ijms24087046 crossref_primary_10_1016_j_neurobiolaging_2018_03_006 crossref_primary_10_1111_febs_15861 crossref_primary_10_12688_f1000research_146156_1 crossref_primary_10_1016_j_coph_2022_102188 crossref_primary_10_1093_brain_awac257 crossref_primary_10_1152_physrev_00050_2017 crossref_primary_10_1186_s41232_021_00181_8 crossref_primary_10_1186_s12974_020_01878_2 crossref_primary_10_1186_s40035_020_00215_0 crossref_primary_10_1016_j_it_2024_03_007 crossref_primary_10_1038_s41398_021_01736_6 crossref_primary_10_1155_2022_7924199 crossref_primary_10_1016_j_jalz_2018_10_005 crossref_primary_10_1016_j_molimm_2018_06_264 crossref_primary_10_1016_j_neuron_2020_09_029 crossref_primary_10_1101_mcs_a003491 crossref_primary_10_1084_jem_20171529 crossref_primary_10_1186_s13195_020_00709_z crossref_primary_10_1038_s41583_018_0113_1 crossref_primary_10_1016_j_cell_2020_07_001 crossref_primary_10_1134_S0006297918090122 crossref_primary_10_1038_s41588_018_0311_9 crossref_primary_10_1093_hmg_ddac126 crossref_primary_10_1038_s12276_024_01386_w crossref_primary_10_1038_s41418_018_0060_4 crossref_primary_10_1016_j_immuni_2023_08_008 crossref_primary_10_1515_mr_2024_0064 crossref_primary_10_1016_j_csbj_2025_01_024 crossref_primary_10_1088_1741_2552_aceca5 crossref_primary_10_1146_annurev_immunol_093019_110159 crossref_primary_10_1002_dad2_12155 crossref_primary_10_1016_j_immuni_2023_08_012 crossref_primary_10_1016_j_immuni_2019_03_016 crossref_primary_10_1111_jnc_14603 crossref_primary_10_1016_j_cell_2018_09_049 crossref_primary_10_1038_sdata_2018_142 crossref_primary_10_1111_bph_14618 crossref_primary_10_1093_brain_awae014 crossref_primary_10_1038_s41593_020_00740_1 crossref_primary_10_1016_j_jmb_2022_167470 crossref_primary_10_1126_scitranslmed_abl7634 crossref_primary_10_1038_s42003_024_06684_7 crossref_primary_10_1186_s40478_020_01050_0 crossref_primary_10_2174_1381612827666210612051713 crossref_primary_10_1093_hmg_ddz163 crossref_primary_10_2139_ssrn_3377366 crossref_primary_10_1186_s40035_022_00315_z crossref_primary_10_1016_j_cmet_2019_08_017 crossref_primary_10_1212_CON_0000000000001125 crossref_primary_10_1016_j_celrep_2020_107807 crossref_primary_10_1371_journal_pgen_1007306 crossref_primary_10_1371_journal_pgen_1007427 crossref_primary_10_3233_JAD_180820 crossref_primary_10_1016_j_jadr_2023_100465 crossref_primary_10_3389_fnagi_2021_653334 crossref_primary_10_1126_sciadv_abo3610 crossref_primary_10_1038_s12276_023_01004_1 crossref_primary_10_1038_s41583_018_0055_7 crossref_primary_10_3389_fnins_2019_00164 crossref_primary_10_3233_JAD_179921 crossref_primary_10_3390_nu14183715 crossref_primary_10_1186_s13024_018_0289_x crossref_primary_10_4103_NRR_NRR_D_23_01688 crossref_primary_10_1038_s41467_023_37437_5 crossref_primary_10_1093_jnen_nlad031 crossref_primary_10_3389_fnagi_2023_1201982 crossref_primary_10_1016_j_ncrna_2018_11_003 crossref_primary_10_1177_10738584211024907 crossref_primary_10_1002_dad2_12255 crossref_primary_10_1007_s40142_018_0155_8 crossref_primary_10_1016_j_cell_2019_08_053 crossref_primary_10_1096_fj_201802592 crossref_primary_10_1038_s41598_020_59917_0 crossref_primary_10_1038_s41598_025_86644_1 crossref_primary_10_1016_j_conb_2019_11_024 crossref_primary_10_1001_jamanetworkopen_2019_1350 crossref_primary_10_1167_iovs_61_8_3 crossref_primary_10_1186_s13024_021_00452_5 crossref_primary_10_3390_biomedicines9040415 crossref_primary_10_1016_j_cell_2018_05_003 crossref_primary_10_1093_hmg_ddaa177 crossref_primary_10_3233_JAD_179938 crossref_primary_10_1016_j_bbi_2019_02_011 crossref_primary_10_1155_2021_5560691 crossref_primary_10_1186_s13195_021_00794_8 crossref_primary_10_1084_jem_20182184 crossref_primary_10_1186_s13024_018_0277_1 crossref_primary_10_1371_journal_pone_0229819 crossref_primary_10_3389_fnins_2020_602508 crossref_primary_10_1097_MS9_0000000000001692 crossref_primary_10_1016_j_neurobiolaging_2020_11_009 crossref_primary_10_1016_j_tins_2020_10_002 crossref_primary_10_1016_S1474_4422_18_30232_1 crossref_primary_10_1177_09636897231171001 crossref_primary_10_3389_fnagi_2022_1035572 crossref_primary_10_1016_j_celrep_2020_01_063 crossref_primary_10_1007_s00401_019_01991_4 crossref_primary_10_2174_1568026620666200603112030 crossref_primary_10_3389_fnagi_2023_1120952 crossref_primary_10_3389_fnagi_2021_646901 crossref_primary_10_1002_dad2_12128 crossref_primary_10_1186_s12864_022_08343_9 crossref_primary_10_3390_cimb45050272 crossref_primary_10_3390_ijms25158118 crossref_primary_10_3389_fneur_2019_01252 crossref_primary_10_1097_WCO_0000000000000797 crossref_primary_10_1126_science_aaw0685 crossref_primary_10_3389_fimmu_2020_00724 crossref_primary_10_1155_2024_9268911 crossref_primary_10_3390_biomedicines9050524 crossref_primary_10_1007_s12017_021_08644_4 crossref_primary_10_1007_s00401_024_02835_6 crossref_primary_10_18632_aging_102352 crossref_primary_10_1016_j_brainres_2019_146510 crossref_primary_10_1038_s41398_019_0485_7 crossref_primary_10_3389_fimmu_2023_1102530 crossref_primary_10_1038_s41416_024_02646_2 crossref_primary_10_1111_cns_13117 crossref_primary_10_1007_s40142_019_0156_2 crossref_primary_10_1038_s41598_021_94324_z crossref_primary_10_3389_fimmu_2023_1168539 crossref_primary_10_1016_j_cell_2018_12_012 crossref_primary_10_3390_ijms24043754 crossref_primary_10_1016_j_ebiom_2020_102634 crossref_primary_10_1038_s41592_019_0509_5 crossref_primary_10_1007_s11357_020_00287_w crossref_primary_10_1016_j_jbc_2021_100631 crossref_primary_10_1590_0004_282x20170126 crossref_primary_10_1038_s41583_021_00533_w crossref_primary_10_1016_j_slasd_2023_03_003 crossref_primary_10_1021_acschemneuro_8b00435 crossref_primary_10_1016_j_nbd_2021_105303 crossref_primary_10_1038_s41593_022_01040_6 crossref_primary_10_1007_s12551_021_00903_9 crossref_primary_10_1016_j_bbr_2022_113977 crossref_primary_10_1007_s12035_024_04143_2 crossref_primary_10_1016_j_joca_2019_11_010 crossref_primary_10_3233_JAD_170702 crossref_primary_10_1007_s11481_019_09839_0 crossref_primary_10_1002_dad2_12074 crossref_primary_10_1371_journal_pgen_1009772 crossref_primary_10_1080_21678421_2018_1451894 crossref_primary_10_3390_jpm11100946 crossref_primary_10_1111_nan_12517 crossref_primary_10_1016_j_plipres_2020_101065 crossref_primary_10_1097_CM9_0000000000002167 crossref_primary_10_1038_s43587_021_00123_6 crossref_primary_10_1186_s13148_024_01690_2 crossref_primary_10_1016_j_cca_2017_11_009 crossref_primary_10_3390_cells9112415 crossref_primary_10_1016_j_brainres_2024_148817 crossref_primary_10_1186_s13024_023_00679_4 crossref_primary_10_15252_emmm_201808931 crossref_primary_10_3233_JAD_201140 crossref_primary_10_3390_cimb46030129 crossref_primary_10_1016_j_nbd_2022_105615 crossref_primary_10_1007_s10654_020_00640_5 crossref_primary_10_1016_j_ajhg_2019_05_018 crossref_primary_10_1016_j_cell_2022_10_007 crossref_primary_10_1186_s12906_025_04745_w crossref_primary_10_1186_s13024_019_0346_0 crossref_primary_10_1038_s41398_020_0839_1 crossref_primary_10_1038_s41598_023_38484_0 crossref_primary_10_1039_C8MT00004B crossref_primary_10_1097_RMR_0000000000000222 crossref_primary_10_7554_eLife_77809 crossref_primary_10_1016_j_celrep_2022_111717 crossref_primary_10_1016_j_bbi_2018_08_006 crossref_primary_10_1371_journal_pgen_1008549 crossref_primary_10_1038_s41467_020_18534_1 crossref_primary_10_3389_fcell_2022_999061 crossref_primary_10_26508_lsa_202101108 crossref_primary_10_1002_prp2_470 crossref_primary_10_1007_s00115_019_0778_3 crossref_primary_10_1007_s10654_017_0321_4 crossref_primary_10_1016_j_neurobiolaging_2020_04_024 crossref_primary_10_3389_fnagi_2021_745381 crossref_primary_10_1172_JCI138179 crossref_primary_10_3390_ijms242115946 crossref_primary_10_1186_s12974_020_02024_8 crossref_primary_10_1186_s13024_023_00645_0 crossref_primary_10_1007_s00401_018_1928_6 crossref_primary_10_1007_s00018_021_03986_5 crossref_primary_10_3389_fmed_2018_00108 crossref_primary_10_1007_s00018_022_04473_1 crossref_primary_10_1080_10408363_2019_1670613 crossref_primary_10_1002_advs_202201212 crossref_primary_10_1016_j_neurobiolaging_2022_07_002 crossref_primary_10_1126_sciadv_abe3954 crossref_primary_10_1186_s10020_019_0090_5 crossref_primary_10_2174_1871527320666210218084444 crossref_primary_10_3390_brainsci11020215 crossref_primary_10_1016_j_neulet_2023_137283 crossref_primary_10_1111_bph_14546 crossref_primary_10_1093_braincomms_fcab308 crossref_primary_10_15252_emmm_202012308 crossref_primary_10_1159_000518820 crossref_primary_10_1016_j_neurobiolaging_2017_09_035 crossref_primary_10_18632_aging_206143 crossref_primary_10_1007_s40142_018_0141_1 |
| Cites_doi | 10.1002/ana.24466 10.1016/j.cell.2015.01.049 10.1371/journal.pgen.1004792 10.1038/ng.2507 10.1038/ng.2354 10.1016/j.gde.2009.04.010 10.1093/hmg/ddv620 10.1038/ng.2802 10.1074/jbc.M114.608091 10.1001/archpsyc.63.2.168 10.1038/ng.3300 10.1007/s10875-015-0177-x 10.1038/ncomms3872 10.1038/ng.801 10.1371/journal.pone.0068095 10.1371/journal.pone.0094661 10.1016/j.neuron.2015.11.013 10.1038/ncomms6965 10.1038/ng.440 10.1038/ng.439 10.1016/0304-3940(90)90748-X 10.1016/j.jneuroim.2006.11.032 10.4049/jimmunol.1200887 10.1371/journal.pgen.0020190 10.1016/j.cub.2005.11.036 10.1016/j.ajhg.2009.05.011 10.1038/ng.f.136 10.1093/brain/awv379 10.1056/NEJMoa1211851 10.1186/1750-1326-8-13 10.1038/nn.3786 10.1016/j.bbadis.2009.10.013 10.1001/jama.2010.574 10.1016/S1074-7613(00)80153-3 10.1038/ng.803 10.1038/ng.3246 10.1016/j.jalz.2014.06.010 10.1126/science.aad8373 10.1371/journal.pone.0069226 10.1038/nm.3736 10.1016/j.jalz.2013.08.163 10.1007/s10072-015-2274-2 10.1093/brain/awv268 10.1093/bioinformatics/bts479 10.1056/NEJMoa1211103 10.1038/ng.3656 10.1038/ng.1027 10.1007/BF00311383 10.1126/science.1246949 10.1186/s12964-015-0119-5 10.1186/s13024-015-0040-9 10.1016/j.neuron.2016.05.003 10.1038/ncomms6897 10.1016/j.jalz.2014.04.405 10.1038/nature11283 10.1038/nn.4126 10.1002/ana.24219 10.1093/bioinformatics/btu704 10.1038/ng.3643 10.1093/bioinformatics/btq340 10.1084/jem.20151948 10.1002/ana.24305 10.1093/hmg/ddu277 10.1016/j.neuron.2013.02.026 10.1086/321272 10.1111/j.0006-341X.1999.00997.x |
| ContentType | Journal Article |
| Copyright | Springer Nature America, Inc. 2017 COPYRIGHT 2017 Nature Publishing Group Copyright Nature Publishing Group Sep 2017 Distributed under a Creative Commons Attribution 4.0 International License |
| Copyright_xml | – notice: Springer Nature America, Inc. 2017 – notice: COPYRIGHT 2017 Nature Publishing Group – notice: Copyright Nature Publishing Group Sep 2017 – notice: Distributed under a Creative Commons Attribution 4.0 International License |
| CorporateAuthor | GERAD/PERADES, CHARGE, ADGC, EADI ARUK Consortium |
| CorporateAuthor_xml | – name: GERAD/PERADES, CHARGE, ADGC, EADI – name: ARUK Consortium |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM IOV ISR 3V. 7QL 7QP 7QR 7SS 7T7 7TK 7TM 7U9 7X7 7XB 88A 88E 8AO 8C1 8FD 8FE 8FH 8FI 8FJ 8FK 8G5 ABUWG AEUYN AFKRA AZQEC BBNVY BENPR BHPHI C1K CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ GUQSH H94 HCIFZ K9. LK8 M0S M1P M2O M7N M7P MBDVC P64 PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS Q9U RC3 7X8 1XC VOOES 5PM ADTPV AOWAS DG7 BTSUP DF2 D8T ZZAVC |
| DOI | 10.1038/ng.3916 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Gale In Context: Opposing Viewpoints Gale In Context: Science ProQuest Central (Corporate) Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Entomology Abstracts (Full archive) Industrial and Applied Microbiology Abstracts (Microbiology A) Neurosciences Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Research Library (Alumni) ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection Environmental Sciences and Pollution Management ProQuest One ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student ProQuest Research Library AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) ProQuest Biological Science Collection ProQuest Health & Medical Collection Medical Database Research Library Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Research Library (Corporate) Biotechnology and BioEngineering Abstracts ProQuest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic Genetics Abstracts MEDLINE - Academic Hyper Article en Ligne (HAL) Hyper Article en Ligne (HAL) (Open Access) PubMed Central (Full Participant titles) SwePub SwePub Articles SWEPUB Stockholms universitet SwePub Editorial SWEPUB Uppsala universitet SWEPUB Freely available online SwePub Articles full text |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Research Library Prep ProQuest Central Student ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Natural Science Collection Health & Medical Research Collection Biological Science Collection Chemoreception Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) ProQuest Central (New) ProQuest Medical Library (Alumni) Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Entomology Abstracts ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts ProQuest One Academic (New) Technology Research Database ProQuest One Academic Middle East (New) ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing Research Library (Alumni Edition) ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Biology Journals (Alumni Edition) ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) AIDS and Cancer Research Abstracts ProQuest Research Library ProQuest Public Health ProQuest Central Basic ProQuest SciTech Collection ProQuest Medical Library ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | Research Library Prep MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Agriculture Biology |
| EISSN | 1546-1718 |
| EndPage | 1384 |
| ExternalDocumentID | oai_swepub_ki_se_495393 oai_DiVA_org_uu_334927 oai_DiVA_org_su_147014 PMC5669039 oai_HAL_inserm_02466466v1 A502334826 28714976 10_1038_ng_3916 |
| Genre | Journal Article |
| GeographicLocations | United States United Kingdom Netherlands |
| GeographicLocations_xml | – name: United Kingdom – name: Netherlands – name: United States |
| GrantInformation_xml | – fundername: NINDS NIH HHS grantid: U24 NS072026 – fundername: NIA NIH HHS grantid: P50 AG025711 – fundername: NIA NIH HHS grantid: P30 AG028377 – fundername: NINDS NIH HHS grantid: P50 NS039764 – fundername: NHLBI NIH HHS grantid: N01 HC055222 – fundername: NIA NIH HHS grantid: P50 AG005144 – fundername: NIA NIH HHS grantid: R01 AG027944 – fundername: Medical Research Council grantid: MR/L023784/1 – fundername: NIA NIH HHS grantid: U01 AG049505 – fundername: NIA NIH HHS grantid: R01 AG030146 |
| GroupedDBID | --- -DZ -~X 0R~ 123 29M 2FS 36B 39C 3V. 4.4 53G 5BI 5RE 70F 7X7 85S 88A 88E 8AO 8C1 8FE 8FH 8FI 8FJ 8G5 8R4 8R5 AAEEF AAHBH AARCD AAYZH AAZLF ABCQX ABJNI ABLJU ABOCM ABUWG ACBWK ACGFO ACGFS ACIWK ACMJI ACNCT ACPRK ADBBV ADFRT AENEX AEUYN AFKRA AFRAH AFSHS AGAYW AGHTU AHBCP AHMBA AHOSX AHSBF AIBTJ ALFFA ALIPV ALMA_UNASSIGNED_HOLDINGS AMTXH ARMCB ASPBG AVWKF AXYYD AZFZN AZQEC BBNVY BENPR BHPHI BKKNO BPHCQ BVXVI CCPQU CS3 DU5 DWQXO EAP EBS EE. EJD ESX EXGXG F5P FEDTE FQGFK FSGXE FYUFA GNUQQ GUQSH GX1 HCIFZ HMCUK HVGLF HZ~ IAO IH2 IHR INH INR IOV ISR ITC L7B LK8 M0L M1P M2O M7P N9A NNMJJ P2P PQQKQ PROAC PSQYO Q2X RNT RNTTT SHXYY SIXXV SJN SNYQT SOJ TAOOD TBHMF TDRGL TN5 TSG UKHRP VQA ~KM AAYXX ABFSG ACMFV ACSTC AETEA AFANA ALPWD ATHPR CITATION PHGZM PHGZT .55 .GJ 3O- 5M7 5S5 ABAWZ ABDBF ABDPE ABEFU ACUHS AEZWR AFBBN AFFNX AFHIU AGCDD AHWEU AIXLP B0M CGR CUY CVF DB5 EAD EBC EBD ECM EIF EMB EMK EMOBN EPL LGEZI LOTEE MVM NADUK NFIDA NPM NXXTH ODYON PJZUB PPXIY PQGLB RIG RNS RVV SV3 TUS X7M XJT XOL Y6R YHZ ZGI ZXP ZY4 ~8M AEIIB PMFND 7QL 7QP 7QR 7SS 7T7 7TK 7TM 7U9 7XB 8FD 8FK C1K FR3 H94 K9. M7N MBDVC P64 PKEHL PQEST PQUKI PRINS Q9U RC3 7X8 1XC PUEGO VOOES 5PM ADTPV AOWAS DG7 BTSUP DF2 D8T ZZAVC |
| ID | FETCH-LOGICAL-c714t-cd70ad7c4a2fe67928728ce8d94f81964ca0a2a0af621c9b79f795eb3ec7dcaf3 |
| IEDL.DBID | 7X7 |
| ISSN | 1061-4036 1546-1718 |
| IngestDate | Mon Aug 25 03:40:07 EDT 2025 Thu Aug 21 07:30:39 EDT 2025 Thu Aug 21 07:01:05 EDT 2025 Thu Aug 21 18:16:57 EDT 2025 Thu Aug 28 06:27:51 EDT 2025 Fri Jul 11 11:02:44 EDT 2025 Fri Jul 25 08:58:51 EDT 2025 Tue Jun 17 21:04:19 EDT 2025 Tue Jun 10 20:48:21 EDT 2025 Fri Jun 27 03:42:08 EDT 2025 Fri Jun 27 04:52:10 EDT 2025 Mon Jul 21 05:50:55 EDT 2025 Thu Apr 24 23:12:56 EDT 2025 Tue Jul 01 01:50:14 EDT 2025 Fri Feb 21 02:39:06 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 9 |
| Language | English |
| License | Distributed under a Creative Commons Attribution 4.0 International License: http://creativecommons.org/licenses/by/4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c714t-cd70ad7c4a2fe67928728ce8d94f81964ca0a2a0af621c9b79f795eb3ec7dcaf3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 PMCID: PMC5669039 equal contribution first author equal contribution senior author |
| ORCID | 0000-0002-8057-2505 0000-0002-7274-7299 0000-0003-3423-2021 0000-0003-0372-8585 0000-0001-9088-234X 0000-0002-6477-1117 0000-0002-6944-748X 0000-0001-8509-148X 0000-0002-7358-7055 0000-0003-2226-4050 0000-0001-5002-5263 0000-0003-0183-7665 0000-0001-7151-4277 0000-0002-2072-8010 0000-0001-9880-9788 0000-0003-3043-3942 0000-0002-4698-1794 0000-0002-1842-8019 0000-0002-1432-0078 0000-0003-1606-8643 0000-0002-1115-4430 0000-0002-6573-983X 0000-0002-4924-7712 0000-0003-0829-7817 0000-0001-9435-9441 0000-0003-3687-2508 0000-0002-3658-1375 0000-0002-9621-2942 0000-0002-7998-5433 0000-0003-1942-5845 0000-0001-7189-7917 0000-0002-0941-3990 0000-0002-5358-4463 0000-0002-4697-122X 0000-0001-5254-7655 0000-0001-8789-5676 0000-0002-7678-5065 0000-0003-0290-7979 0000-0002-2786-8200 0000-0003-4798-0862 0000-0002-7432-4249 0000-0003-4026-2884 0000-0002-1340-638X 0000-0002-6824-6942 0000-0003-2814-7461 0000-0002-2568-5478 0000-0003-0894-8982 0000-0002-2634-7198 0000-0001-9281-7402 0000-0003-0568-2998 0000-0002-6517-2984 0000-0002-2785-9937 0000-0002-1876-6368 0000-0001-7415-7607 0000-0003-2556-2563 0000-0002-0688-8982 0000-0002-0576-2472 0000-0002-8096-3987 |
| OpenAccessLink | https://inserm.hal.science/inserm-02466466 |
| PMID | 28714976 |
| PQID | 1938055678 |
| PQPubID | 33429 |
| PageCount | 12 |
| ParticipantIDs | swepub_primary_oai_swepub_ki_se_495393 swepub_primary_oai_DiVA_org_uu_334927 swepub_primary_oai_DiVA_org_su_147014 pubmedcentral_primary_oai_pubmedcentral_nih_gov_5669039 hal_primary_oai_HAL_inserm_02466466v1 proquest_miscellaneous_1920194524 proquest_journals_1938055678 gale_infotracmisc_A502334826 gale_infotracacademiconefile_A502334826 gale_incontextgauss_ISR_A502334826 gale_incontextgauss_IOV_A502334826 pubmed_primary_28714976 crossref_primary_10_1038_ng_3916 crossref_citationtrail_10_1038_ng_3916 springer_journals_10_1038_ng_3916 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2017-09-01 |
| PublicationDateYYYYMMDD | 2017-09-01 |
| PublicationDate_xml | – month: 09 year: 2017 text: 2017-09-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | New York |
| PublicationPlace_xml | – name: New York – name: United States |
| PublicationTitle | Nature genetics |
| PublicationTitleAbbrev | Nat Genet |
| PublicationTitleAlternate | Nat Genet |
| PublicationYear | 2017 |
| Publisher | Nature Publishing Group US Nature Publishing Group |
| Publisher_xml | – name: Nature Publishing Group US – name: Nature Publishing Group |
| References | Wang (CR47) 2015; 160 Neumann, Takahashi (CR44) 2007; 184 Lu, Liu, Wang (CR35) 2015; 36 Grove (CR61) 2013; 8 Ulrich (CR46) 2013; 8 Kurosaki, Tsukada (CR56) 2000; 12 CR37 Lambert (CR4) 2009; 41 Wang (CR57) 2016; 213 CR31 Rademakers (CR48) 2011; 44 Escott-Price (CR5) 2014; 9 Hunkapiller (CR23) 2013; 9 Das (CR32) 2016; 48 Vardarajan (CR19) 2015; 78 Perlmutter, Barron, Chui (CR49) 1990; 119 Wisniewski, Wegiel, Wang, Lach (CR50) 1992; 84 Steinberg (CR20) 2015; 47 Logue (CR21) 2014; 10 Hong (CR52) 2016; 352 Schork, Murray, Frazer, Topol (CR16) 2009; 19 De Jager (CR68) 2014; 17 Painter (CR45) 2015; 10 Jun (CR22) 2014; 76 Cruchaga (CR36) 2013; 78 Devlin, Roeder (CR60) 1999; 55 Escott-Price (CR13) 2015; 138 Seshadri (CR12) 2010; 303 Gatz (CR1) 2006; 63 Bodmer, Bonilla (CR14) 2008; 40 Bao (CR55) 2012; 189 Hollingworth (CR6) 2011; 43 Willer, Li, Abecasis (CR30) 2010; 26 Surakka (CR17) 2015; 47 Yuan (CR58) 2016; 90 Fuchsberger, Abecasis, Hinds (CR64) 2015; 31 Harold (CR3) 2009; 41 Milner (CR39) 2015; 35 Olmos-Alonso (CR53) 2016; 139 Naj (CR7) 2011; 43 Nolz (CR42) 2006; 16 Jin (CR34) 2014; 23 Paris (CR54) 2014; 289 Jonsson (CR10) 2012; 488 Igartua (CR27) 2015; 6 Huyghe (CR29) 2013; 45 Fairfax (CR40) 2014; 343 Chan (CR69) 2015; 18 Xing, Titus, Humphrey (CR43) 2015; 5 Richards (CR25) 2016; 25 Pritchard (CR15) 2001; 69 Jonsson (CR9) 2013; 368 Guerreiro (CR11) 2013; 368 Goldstein (CR59) 2012; 28 Tachmazidou (CR28) 2013; 4 Holmans (CR66) 2009; 85 Talluri, Shete (CR65) 2013; 8 Zhang (CR38) 2016; 89 Ruiz (CR8) 2014; 10 Wessel (CR26) 2015; 6 Howie, Fuchsberger, Stephens, Marchini, Abecasis (CR63) 2012; 44 Sekino (CR41) 2015; 13 Lim (CR67) 2014; 10 Wetzel-Smith (CR24) 2014; 20 Patterson, Price, Reich (CR62) 2006; 2 McCarthy (CR33) 2016; 48 Vardarajan (CR18) 2015; 77 Schwab, Klegeris, McGeer (CR51) 2010; 1802 Lambert (CR2) 2013; 45 MK Wetzel-Smith (BFng3916_CR24) 2014; 20 M Gatz (BFng3916_CR1) 2006; 63 J Hunkapiller (BFng3916_CR23) 2013; 9 J-C Lambert (BFng3916_CR4) 2009; 41 T Jonsson (BFng3916_CR9) 2013; 368 ML Grove (BFng3916_CR61) 2013; 8 JD Ulrich (BFng3916_CR46) 2013; 8 J-C Lambert (BFng3916_CR2) 2013; 45 JK Pritchard (BFng3916_CR15) 2001; 69 JR Huyghe (BFng3916_CR29) 2013; 45 LS Perlmutter (BFng3916_CR49) 1990; 119 B Devlin (BFng3916_CR60) 1999; 55 J Wessel (BFng3916_CR26) 2015; 6 JC Nolz (BFng3916_CR42) 2006; 16 C Fuchsberger (BFng3916_CR64) 2015; 31 P Yuan (BFng3916_CR58) 2016; 90 G Jun (BFng3916_CR22) 2014; 76 A Ruiz (BFng3916_CR8) 2014; 10 MM Painter (BFng3916_CR45) 2015; 10 M Bao (BFng3916_CR55) 2012; 189 PL De Jager (BFng3916_CR68) 2014; 17 J Xing (BFng3916_CR43) 2015; 5 Y Wang (BFng3916_CR47) 2015; 160 HM Wisniewski (BFng3916_CR50) 1992; 84 W Bodmer (BFng3916_CR14) 2008; 40 SC Jin (BFng3916_CR34) 2014; 23 BN Vardarajan (BFng3916_CR19) 2015; 78 A Olmos-Alonso (BFng3916_CR53) 2016; 139 Y Lu (BFng3916_CR35) 2015; 36 N Patterson (BFng3916_CR62) 2006; 2 Y Wang (BFng3916_CR57) 2016; 213 B Howie (BFng3916_CR63) 2012; 44 V Escott-Price (BFng3916_CR5) 2014; 9 S Das (BFng3916_CR32) 2016; 48 D Paris (BFng3916_CR54) 2014; 289 I Surakka (BFng3916_CR17) 2015; 47 H Neumann (BFng3916_CR44) 2007; 184 T Kurosaki (BFng3916_CR56) 2000; 12 S Sekino (BFng3916_CR41) 2015; 13 R Guerreiro (BFng3916_CR11) 2013; 368 NJ Schork (BFng3916_CR16) 2009; 19 MW Logue (BFng3916_CR21) 2014; 10 Y Zhang (BFng3916_CR38) 2016; 89 S Seshadri (BFng3916_CR12) 2010; 303 R Talluri (BFng3916_CR65) 2013; 8 S Hong (BFng3916_CR52) 2016; 352 P Hollingworth (BFng3916_CR6) 2011; 43 S Steinberg (BFng3916_CR20) 2015; 47 C Schwab (BFng3916_CR51) 2010; 1802 V Escott-Price (BFng3916_CR13) 2015; 138 D Harold (BFng3916_CR3) 2009; 41 C Igartua (BFng3916_CR27) 2015; 6 C Cruchaga (BFng3916_CR36) 2013; 78 JI Goldstein (BFng3916_CR59) 2012; 28 I Tachmazidou (BFng3916_CR28) 2013; 4 CJ Willer (BFng3916_CR30) 2010; 26 R Rademakers (BFng3916_CR48) 2011; 44 ASP Lim (BFng3916_CR67) 2014; 10 BFng3916_CR31 BFng3916_CR37 P Holmans (BFng3916_CR66) 2009; 85 BP Fairfax (BFng3916_CR40) 2014; 343 BN Vardarajan (BFng3916_CR18) 2015; 77 AL Richards (BFng3916_CR25) 2016; 25 G Chan (BFng3916_CR69) 2015; 18 AC Naj (BFng3916_CR7) 2011; 43 T Jonsson (BFng3916_CR10) 2012; 488 S McCarthy (BFng3916_CR33) 2016; 48 JD Milner (BFng3916_CR39) 2015; 35 |
| References_xml | – volume: 78 start-page: 487 year: 2015 end-page: 498 ident: CR19 article-title: Rare coding mutations identified by sequencing of Alzheimer disease genome-wide association studies loci publication-title: Ann. Neurol. doi: 10.1002/ana.24466 – volume: 160 start-page: 1061 year: 2015 end-page: 1071 ident: CR47 article-title: TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model publication-title: Cell doi: 10.1016/j.cell.2015.01.049 – volume: 10 start-page: e1004792 year: 2014 ident: CR67 article-title: 24-hour rhythms of DNA methylation and their relation with rhythms of RNA expression in the human dorsolateral prefrontal cortex publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1004792 – volume: 45 start-page: 197 year: 2013 end-page: 201 ident: CR29 article-title: Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion publication-title: Nat. Genet. doi: 10.1038/ng.2507 – volume: 44 start-page: 955 year: 2012 end-page: 959 ident: CR63 article-title: Fast and accurate genotype imputation in genome-wide association studies through pre-phasing publication-title: Nat. Genet. doi: 10.1038/ng.2354 – volume: 19 start-page: 212 year: 2009 end-page: 219 ident: CR16 article-title: Common vs. rare allele hypotheses for complex diseases publication-title: Curr. Opin. Genet. Dev. doi: 10.1016/j.gde.2009.04.010 – volume: 25 start-page: 1001 year: 2016 end-page: 1007 ident: CR25 article-title: Exome arrays capture polygenic rare variant contributions to schizophrenia publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddv620 – volume: 45 start-page: 1452 year: 2013 end-page: 1458 ident: CR2 article-title: Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease publication-title: Nat. Genet. doi: 10.1038/ng.2802 – volume: 289 start-page: 33927 year: 2014 end-page: 33944 ident: CR54 article-title: The spleen tyrosine kinase (Syk) regulates Alzheimer amyloid-β production and tau hyperphosphorylation publication-title: J. Biol. Chem. doi: 10.1074/jbc.M114.608091 – volume: 63 start-page: 168 year: 2006 end-page: 174 ident: CR1 article-title: Role of genes and environments for explaining Alzheimer disease publication-title: Arch. Gen. Psychiatry doi: 10.1001/archpsyc.63.2.168 – volume: 47 start-page: 589 year: 2015 end-page: 597 ident: CR17 article-title: The impact of low-frequency and rare variants on lipid levels publication-title: Nat. Genet. doi: 10.1038/ng.3300 – volume: 35 start-page: 527 year: 2015 end-page: 530 ident: CR39 article-title: PLAID: a syndrome of complex patterns of disease and unique phenotypes publication-title: J. Clin. Immunol. doi: 10.1007/s10875-015-0177-x – volume: 4 start-page: 2872 year: 2013 ident: CR28 article-title: A rare functional cardioprotective variant has risen in frequency in distinct population isolates publication-title: Nat. Commun. doi: 10.1038/ncomms3872 – volume: 43 start-page: 436 year: 2011 end-page: 441 ident: CR7 article-title: Common variants at / , , and are associated with late-onset Alzheimer's disease publication-title: Nat. Genet. doi: 10.1038/ng.801 – volume: 8 start-page: e68095 year: 2013 ident: CR61 article-title: Best practices and joint calling of the HumanExome BeadChip: the CHARGE Consortium publication-title: PLoS One doi: 10.1371/journal.pone.0068095 – volume: 9 start-page: e94661 year: 2014 ident: CR5 article-title: Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease publication-title: PLoS One doi: 10.1371/journal.pone.0094661 – volume: 89 start-page: 37 year: 2016 end-page: 53 ident: CR38 article-title: Purification and characterization of progenitor and mature human astrocytes reveals transcriptional and functional differences with mouse publication-title: Neuron doi: 10.1016/j.neuron.2015.11.013 – volume: 6 start-page: 5965 year: 2015 ident: CR27 article-title: Ethnic-specific associations of rare and low-frequency DNA sequence variants with asthma publication-title: Nat. Commun. doi: 10.1038/ncomms6965 – volume: 41 start-page: 1088 year: 2009 end-page: 1093 ident: CR3 article-title: Genome-wide association study identifies variants at and associated with Alzheimer's disease publication-title: Nat. Genet. doi: 10.1038/ng.440 – volume: 41 start-page: 1094 year: 2009 end-page: 1099 ident: CR4 article-title: Genome-wide association study identifies variants at and associated with Alzheimer's disease publication-title: Nat. Genet. doi: 10.1038/ng.439 – volume: 119 start-page: 32 year: 1990 end-page: 36 ident: CR49 article-title: Morphologic association between microglia and senile plaque amyloid in Alzheimer's disease publication-title: Neurosci. Lett. doi: 10.1016/0304-3940(90)90748-X – volume: 184 start-page: 92 year: 2007 end-page: 99 ident: CR44 article-title: Essential role of the microglial triggering receptor expressed on myeloid cells-2 (TREM2) for central nervous tissue immune homeostasis publication-title: J. Neuroimmunol. doi: 10.1016/j.jneuroim.2006.11.032 – volume: 189 start-page: 786 year: 2012 end-page: 792 ident: CR55 article-title: CD2AP/SHIP1 complex positively regulates plasmacytoid dendritic cell receptor signaling by inhibiting the E3 ubiquitin ligase Cbl publication-title: J. Immunol. doi: 10.4049/jimmunol.1200887 – volume: 2 start-page: e190 year: 2006 ident: CR62 article-title: Population structure and eigenanalysis publication-title: PLoS Genet. doi: 10.1371/journal.pgen.0020190 – volume: 16 start-page: 24 year: 2006 end-page: 34 ident: CR42 article-title: The WAVE2 complex regulates actin cytoskeletal reorganization and CRAC-mediated calcium entry during T cell activation publication-title: Curr. Biol. doi: 10.1016/j.cub.2005.11.036 – volume: 85 start-page: 13 year: 2009 end-page: 24 ident: CR66 article-title: Gene ontology analysis of GWA study data sets provides insights into the biology of bipolar disorder publication-title: Am. J. Hum. Genet. doi: 10.1016/j.ajhg.2009.05.011 – volume: 40 start-page: 695 year: 2008 end-page: 701 ident: CR14 article-title: Common and rare variants in multifactorial susceptibility to common diseases publication-title: Nat. Genet. doi: 10.1038/ng.f.136 – volume: 139 start-page: 891 year: 2016 end-page: 907 ident: CR53 article-title: Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer's-like pathology publication-title: Brain doi: 10.1093/brain/awv379 – volume: 368 start-page: 117 year: 2013 end-page: 127 ident: CR11 article-title: variants in Alzheimer's disease publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa1211851 – volume: 8 start-page: 13 year: 2013 ident: CR46 article-title: measurement of apolipoprotein E from the brain interstitial fluid using microdialysis publication-title: Mol. Neurodegener. doi: 10.1186/1750-1326-8-13 – volume: 17 start-page: 1156 year: 2014 end-page: 1163 ident: CR68 article-title: Alzheimer's disease: early alterations in brain DNA methylation at , , and other loci publication-title: Nat. Neurosci. doi: 10.1038/nn.3786 – volume: 1802 start-page: 889 year: 2010 end-page: 902 ident: CR51 article-title: Inflammation in transgenic mouse models of neurodegenerative disorders publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbadis.2009.10.013 – volume: 303 start-page: 1832 year: 2010 end-page: 1840 ident: CR12 article-title: Genome-wide analysis of genetic loci associated with Alzheimer disease publication-title: J. Am. Med. Assoc. doi: 10.1001/jama.2010.574 – volume: 12 start-page: 1 year: 2000 end-page: 5 ident: CR56 article-title: BLNK: connecting Syk and Btk to calcium signals publication-title: Immunity doi: 10.1016/S1074-7613(00)80153-3 – volume: 43 start-page: 429 year: 2011 end-page: 435 ident: CR6 article-title: Common variants at , / , , and are associated with Alzheimer's disease publication-title: Nat. Genet. doi: 10.1038/ng.803 – ident: CR37 – volume: 47 start-page: 445 year: 2015 end-page: 447 ident: CR20 article-title: Loss-of-function variants in confer risk of Alzheimer's disease publication-title: Nat. Genet. doi: 10.1038/ng.3246 – volume: 5 start-page: 89 year: 2015 end-page: 100 ident: CR43 article-title: The TREM2–DAP12 signaling pathway in Nasu–Hakola disease: a molecular genetics perspective publication-title: Res. Rep. Biochem. – volume: 10 start-page: 609 year: 2014 end-page: 618 ident: CR21 article-title: Two rare variants are associated with Alzheimer's disease in African Americans publication-title: Alzheimers Dement. doi: 10.1016/j.jalz.2014.06.010 – volume: 352 start-page: 712 year: 2016 end-page: 716 ident: CR52 article-title: Complement and microglia mediate early synapse loss in Alzheimer mouse models publication-title: Science doi: 10.1126/science.aad8373 – volume: 8 start-page: e69226 year: 2013 ident: CR65 article-title: A linkage disequilibrium–based approach to selecting disease-associated rare variants publication-title: PLoS One doi: 10.1371/journal.pone.0069226 – volume: 20 start-page: 1452 year: 2014 end-page: 1457 ident: CR24 article-title: A rare mutation in predisposes to late-onset Alzheimer's disease and increases neuronal cell death publication-title: Nat. Med. doi: 10.1038/nm.3736 – volume: 55 start-page: 997 year: 1999 end-page: 1004 ident: CR60 article-title: Genomic control for association studies publication-title: Biometrics – volume: 9 start-page: 853 year: 2013 ident: CR23 article-title: A rare coding variant alters function and predisposes to Alzheimer's disease publication-title: Alzheimers Dement. doi: 10.1016/j.jalz.2013.08.163 – volume: 36 start-page: 1881 year: 2015 end-page: 1888 ident: CR35 article-title: variants and risk of Alzheimer's disease: a meta-analysis publication-title: Neurol. Sci. doi: 10.1007/s10072-015-2274-2 – volume: 138 start-page: 3673 year: 2015 end-page: 3684 ident: CR13 article-title: Common polygenic variation enhances risk prediction for Alzheimer's disease publication-title: Brain doi: 10.1093/brain/awv268 – volume: 28 start-page: 2543 year: 2012 end-page: 2545 ident: CR59 article-title: zCall: a rare variant caller for array-based genotyping: genetics and population analysis publication-title: Bioinformatics doi: 10.1093/bioinformatics/bts479 – volume: 368 start-page: 107 year: 2013 end-page: 116 ident: CR9 article-title: Variant of associated with the risk of Alzheimer's disease publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa1211103 – volume: 48 start-page: 1284 year: 2016 end-page: 1287 ident: CR32 article-title: Next-generation genotype imputation service and methods publication-title: Nat. Genet. doi: 10.1038/ng.3656 – volume: 44 start-page: 200 year: 2011 end-page: 205 ident: CR48 article-title: Mutations in the colony stimulating factor 1 receptor ( ) gene cause hereditary diffuse leukoencephalopathy with spheroids publication-title: Nat. Genet. doi: 10.1038/ng.1027 – volume: 84 start-page: 117 year: 1992 end-page: 127 ident: CR50 article-title: Ultrastructural studies of the cells forming amyloid in the cortical vessel wall in Alzheimer's disease publication-title: Acta Neuropathol. doi: 10.1007/BF00311383 – volume: 343 start-page: 1246949 year: 2014 ident: CR40 article-title: Innate immune activity conditions the effect of regulatory variants upon monocyte gene expression publication-title: Science doi: 10.1126/science.1246949 – volume: 13 start-page: 41 year: 2015 ident: CR41 article-title: The NESH/Abi-3-based WAVE2 complex is functionally distinct from the Abi-1-based WAVE2 complex publication-title: Cell Commun. Signal. doi: 10.1186/s12964-015-0119-5 – volume: 10 start-page: 43 year: 2015 ident: CR45 article-title: TREM2 in CNS homeostasis and neurodegenerative disease publication-title: Mol. Neurodegener. doi: 10.1186/s13024-015-0040-9 – volume: 90 start-page: 724 year: 2016 end-page: 739 ident: CR58 article-title: TREM2 haplodeficiency in mice and humans impairs the microglia barrier function leading to decreased amyloid compaction and severe axonal dystrophy publication-title: Neuron doi: 10.1016/j.neuron.2016.05.003 – volume: 6 start-page: 5897 year: 2015 ident: CR26 article-title: Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility publication-title: Nat. Commun. doi: 10.1038/ncomms6897 – volume: 10 start-page: 257 year: 2014 end-page: P258 ident: CR8 article-title: Toward fine mapping and functional characterization of genome-wide association study–identified locus rs74615166 ( ) for Alzheimer's disease publication-title: Alzheimers Dement. doi: 10.1016/j.jalz.2014.04.405 – volume: 488 start-page: 96 year: 2012 end-page: 99 ident: CR10 article-title: A mutation in protects against Alzheimer's disease and age-related cognitive decline publication-title: Nature doi: 10.1038/nature11283 – volume: 18 start-page: 1556 year: 2015 end-page: 1558 ident: CR69 article-title: CD33 modulates TREM2: convergence of Alzheimer loci publication-title: Nat. Neurosci. doi: 10.1038/nn.4126 – volume: 76 start-page: 379 year: 2014 end-page: 392 ident: CR22 article-title: is associated with Alzheimer disease and modulates tau phosphorylation publication-title: Ann. Neurol. doi: 10.1002/ana.24219 – ident: CR31 – volume: 31 start-page: 782 year: 2015 end-page: 784 ident: CR64 article-title: minimac2: faster genotype imputation publication-title: Bioinformatics doi: 10.1093/bioinformatics/btu704 – volume: 48 start-page: 1279 year: 2016 end-page: 1283 ident: CR33 article-title: A reference panel of 64,976 haplotypes for genotype imputation publication-title: Nat. Genet. doi: 10.1038/ng.3643 – volume: 26 start-page: 2190 year: 2010 end-page: 2191 ident: CR30 article-title: METAL: fast and efficient meta-analysis of genomewide association scans publication-title: Bioinformatics doi: 10.1093/bioinformatics/btq340 – volume: 213 start-page: 667 year: 2016 end-page: 675 ident: CR57 article-title: TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques publication-title: J. Exp. Med. doi: 10.1084/jem.20151948 – volume: 77 start-page: 215 year: 2015 end-page: 227 ident: CR18 article-title: Coding mutations in and Alzheimer disease publication-title: Ann. Neurol. doi: 10.1002/ana.24305 – volume: 23 start-page: 5838 year: 2014 end-page: 5846 ident: CR34 article-title: Coding variants in increase risk for Alzheimer's disease publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddu277 – volume: 78 start-page: 256 year: 2013 end-page: 268 ident: CR36 article-title: GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease publication-title: Neuron doi: 10.1016/j.neuron.2013.02.026 – volume: 69 start-page: 124 year: 2001 end-page: 137 ident: CR15 article-title: Are rare variants responsible for susceptibility to complex diseases? publication-title: Am. J. Hum. Genet. doi: 10.1086/321272 – volume: 90 start-page: 724 year: 2016 ident: BFng3916_CR58 publication-title: Neuron doi: 10.1016/j.neuron.2016.05.003 – volume: 77 start-page: 215 year: 2015 ident: BFng3916_CR18 publication-title: Ann. Neurol. doi: 10.1002/ana.24305 – volume: 41 start-page: 1088 year: 2009 ident: BFng3916_CR3 publication-title: Nat. Genet. doi: 10.1038/ng.440 – volume: 10 start-page: 609 year: 2014 ident: BFng3916_CR21 publication-title: Alzheimers Dement. doi: 10.1016/j.jalz.2014.06.010 – volume: 36 start-page: 1881 year: 2015 ident: BFng3916_CR35 publication-title: Neurol. Sci. doi: 10.1007/s10072-015-2274-2 – volume: 13 start-page: 41 year: 2015 ident: BFng3916_CR41 publication-title: Cell Commun. Signal. doi: 10.1186/s12964-015-0119-5 – volume: 213 start-page: 667 year: 2016 ident: BFng3916_CR57 publication-title: J. Exp. Med. doi: 10.1084/jem.20151948 – volume: 76 start-page: 379 year: 2014 ident: BFng3916_CR22 publication-title: Ann. Neurol. doi: 10.1002/ana.24219 – volume: 43 start-page: 436 year: 2011 ident: BFng3916_CR7 publication-title: Nat. Genet. doi: 10.1038/ng.801 – volume: 352 start-page: 712 year: 2016 ident: BFng3916_CR52 publication-title: Science doi: 10.1126/science.aad8373 – volume: 119 start-page: 32 year: 1990 ident: BFng3916_CR49 publication-title: Neurosci. Lett. doi: 10.1016/0304-3940(90)90748-X – volume: 40 start-page: 695 year: 2008 ident: BFng3916_CR14 publication-title: Nat. Genet. doi: 10.1038/ng.f.136 – volume: 47 start-page: 445 year: 2015 ident: BFng3916_CR20 publication-title: Nat. Genet. doi: 10.1038/ng.3246 – volume: 1802 start-page: 889 year: 2010 ident: BFng3916_CR51 publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbadis.2009.10.013 – volume: 41 start-page: 1094 year: 2009 ident: BFng3916_CR4 publication-title: Nat. Genet. doi: 10.1038/ng.439 – volume: 6 start-page: 5965 year: 2015 ident: BFng3916_CR27 publication-title: Nat. Commun. doi: 10.1038/ncomms6965 – volume: 368 start-page: 107 year: 2013 ident: BFng3916_CR9 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa1211103 – volume: 85 start-page: 13 year: 2009 ident: BFng3916_CR66 publication-title: Am. J. Hum. Genet. doi: 10.1016/j.ajhg.2009.05.011 – volume: 9 start-page: 853 year: 2013 ident: BFng3916_CR23 publication-title: Alzheimers Dement. doi: 10.1016/j.jalz.2013.08.163 – volume: 44 start-page: 955 year: 2012 ident: BFng3916_CR63 publication-title: Nat. Genet. doi: 10.1038/ng.2354 – volume: 78 start-page: 487 year: 2015 ident: BFng3916_CR19 publication-title: Ann. Neurol. doi: 10.1002/ana.24466 – volume: 45 start-page: 197 year: 2013 ident: BFng3916_CR29 publication-title: Nat. Genet. doi: 10.1038/ng.2507 – volume: 44 start-page: 200 year: 2011 ident: BFng3916_CR48 publication-title: Nat. Genet. doi: 10.1038/ng.1027 – volume: 47 start-page: 589 year: 2015 ident: BFng3916_CR17 publication-title: Nat. Genet. doi: 10.1038/ng.3300 – volume: 18 start-page: 1556 year: 2015 ident: BFng3916_CR69 publication-title: Nat. Neurosci. doi: 10.1038/nn.4126 – volume: 303 start-page: 1832 year: 2010 ident: BFng3916_CR12 publication-title: J. Am. Med. Assoc. doi: 10.1001/jama.2010.574 – volume: 139 start-page: 891 year: 2016 ident: BFng3916_CR53 publication-title: Brain doi: 10.1093/brain/awv379 – volume: 25 start-page: 1001 year: 2016 ident: BFng3916_CR25 publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddv620 – volume: 138 start-page: 3673 year: 2015 ident: BFng3916_CR13 publication-title: Brain doi: 10.1093/brain/awv268 – ident: BFng3916_CR31 – volume: 10 start-page: 43 year: 2015 ident: BFng3916_CR45 publication-title: Mol. Neurodegener. doi: 10.1186/s13024-015-0040-9 – volume: 8 start-page: e69226 year: 2013 ident: BFng3916_CR65 publication-title: PLoS One doi: 10.1371/journal.pone.0069226 – volume: 17 start-page: 1156 year: 2014 ident: BFng3916_CR68 publication-title: Nat. Neurosci. doi: 10.1038/nn.3786 – volume: 69 start-page: 124 year: 2001 ident: BFng3916_CR15 publication-title: Am. J. Hum. Genet. doi: 10.1086/321272 – volume: 48 start-page: 1284 year: 2016 ident: BFng3916_CR32 publication-title: Nat. Genet. doi: 10.1038/ng.3656 – volume: 78 start-page: 256 year: 2013 ident: BFng3916_CR36 publication-title: Neuron doi: 10.1016/j.neuron.2013.02.026 – volume: 45 start-page: 1452 year: 2013 ident: BFng3916_CR2 publication-title: Nat. Genet. doi: 10.1038/ng.2802 – volume: 10 start-page: e1004792 year: 2014 ident: BFng3916_CR67 publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1004792 – volume: 160 start-page: 1061 year: 2015 ident: BFng3916_CR47 publication-title: Cell doi: 10.1016/j.cell.2015.01.049 – volume: 488 start-page: 96 year: 2012 ident: BFng3916_CR10 publication-title: Nature doi: 10.1038/nature11283 – volume: 9 start-page: e94661 year: 2014 ident: BFng3916_CR5 publication-title: PLoS One doi: 10.1371/journal.pone.0094661 – volume: 16 start-page: 24 year: 2006 ident: BFng3916_CR42 publication-title: Curr. Biol. doi: 10.1016/j.cub.2005.11.036 – volume: 189 start-page: 786 year: 2012 ident: BFng3916_CR55 publication-title: J. Immunol. doi: 10.4049/jimmunol.1200887 – volume: 20 start-page: 1452 year: 2014 ident: BFng3916_CR24 publication-title: Nat. Med. doi: 10.1038/nm.3736 – volume: 26 start-page: 2190 year: 2010 ident: BFng3916_CR30 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btq340 – volume: 184 start-page: 92 year: 2007 ident: BFng3916_CR44 publication-title: J. Neuroimmunol. doi: 10.1016/j.jneuroim.2006.11.032 – volume: 23 start-page: 5838 year: 2014 ident: BFng3916_CR34 publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddu277 – volume: 10 start-page: 257 year: 2014 ident: BFng3916_CR8 publication-title: Alzheimers Dement. doi: 10.1016/j.jalz.2014.04.405 – volume: 368 start-page: 117 year: 2013 ident: BFng3916_CR11 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa1211851 – volume: 2 start-page: e190 year: 2006 ident: BFng3916_CR62 publication-title: PLoS Genet. doi: 10.1371/journal.pgen.0020190 – volume: 8 start-page: 13 year: 2013 ident: BFng3916_CR46 publication-title: Mol. Neurodegener. doi: 10.1186/1750-1326-8-13 – volume: 12 start-page: 1 year: 2000 ident: BFng3916_CR56 publication-title: Immunity doi: 10.1016/S1074-7613(00)80153-3 – volume: 43 start-page: 429 year: 2011 ident: BFng3916_CR6 publication-title: Nat. Genet. doi: 10.1038/ng.803 – volume: 19 start-page: 212 year: 2009 ident: BFng3916_CR16 publication-title: Curr. Opin. Genet. Dev. doi: 10.1016/j.gde.2009.04.010 – volume: 5 start-page: 89 year: 2015 ident: BFng3916_CR43 publication-title: Res. Rep. Biochem. – volume: 6 start-page: 5897 year: 2015 ident: BFng3916_CR26 publication-title: Nat. Commun. doi: 10.1038/ncomms6897 – ident: BFng3916_CR37 – volume: 63 start-page: 168 year: 2006 ident: BFng3916_CR1 publication-title: Arch. Gen. Psychiatry doi: 10.1001/archpsyc.63.2.168 – volume: 89 start-page: 37 year: 2016 ident: BFng3916_CR38 publication-title: Neuron doi: 10.1016/j.neuron.2015.11.013 – volume: 48 start-page: 1279 year: 2016 ident: BFng3916_CR33 publication-title: Nat. Genet. doi: 10.1038/ng.3643 – volume: 84 start-page: 117 year: 1992 ident: BFng3916_CR50 publication-title: Acta Neuropathol. doi: 10.1007/BF00311383 – volume: 31 start-page: 782 year: 2015 ident: BFng3916_CR64 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btu704 – volume: 4 start-page: 2872 year: 2013 ident: BFng3916_CR28 publication-title: Nat. Commun. doi: 10.1038/ncomms3872 – volume: 55 start-page: 997 year: 1999 ident: BFng3916_CR60 publication-title: Biometrics doi: 10.1111/j.0006-341X.1999.00997.x – volume: 343 start-page: 1246949 year: 2014 ident: BFng3916_CR40 publication-title: Science doi: 10.1126/science.1246949 – volume: 28 start-page: 2543 year: 2012 ident: BFng3916_CR59 publication-title: Bioinformatics doi: 10.1093/bioinformatics/bts479 – volume: 8 start-page: e68095 year: 2013 ident: BFng3916_CR61 publication-title: PLoS One doi: 10.1371/journal.pone.0068095 – volume: 35 start-page: 527 year: 2015 ident: BFng3916_CR39 publication-title: J. Clin. Immunol. doi: 10.1007/s10875-015-0177-x – volume: 289 start-page: 33927 year: 2014 ident: BFng3916_CR54 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M114.608091 |
| SSID | ssj0014408 |
| Score | 2.6834302 |
| Snippet | Sven van der Lee, Julie Williams, Gerard Schellenberg and colleagues identify rare coding variants in
PLCG2
,
ABI3
and
TREM2
associated with Alzheimer's... We identified rare coding variants associated with Alzheimer's disease in a three-stage case-control study of 85,133 subjects. In stage 1, we genotyped 34,174... We identified rare coding variants associated with Alzheimer’s disease (AD) in a 3-stage case-control study of 85,133 subjects. In stage 1, 34,174 samples were... |
| SourceID | swepub pubmedcentral hal proquest gale pubmed crossref springer |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 1373 |
| SubjectTerms | 45/43 631/208/205/2138 692/699/375/365/1283 Adaptor Proteins, Signal Transducing - genetics Agriculture Alzheimer Disease - genetics Alzheimer's disease Amino Acid Sequence Animal Genetics and Genomics Bioinformatics Biomedicine Cancer Research Case-Control Studies Consortia Development and progression Disease control DNA methylation DNA microarrays Exome - genetics Gene Expression Profiling Gene Frequency Gene Function Genes Genetic aspects Genetic Predisposition to Disease - genetics Genetic variation Genomes Genomics Genotype Genotypes Genotyping Human Genetics Humans Immune response Immune system Immunity Immunity (Disease) Immunity, Innate - genetics Innate immunity letter Life Sciences Linkage Disequilibrium Membrane Glycoproteins - genetics Microglia Microglia - metabolism Neurodegenerative diseases Neurons and Cognition Odds Ratio Phospholipase C gamma - genetics Physiological aspects Polymorphism, Single Nucleotide Protein interaction Protein Interaction Maps - genetics Proteins Receptors, Immunologic - genetics Sequence Homology, Amino Acid Studies |
| Title | Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease |
| URI | https://link.springer.com/article/10.1038/ng.3916 https://www.ncbi.nlm.nih.gov/pubmed/28714976 https://www.proquest.com/docview/1938055678 https://www.proquest.com/docview/1920194524 https://inserm.hal.science/inserm-02466466 https://pubmed.ncbi.nlm.nih.gov/PMC5669039 https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-147014 https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-334927 http://kipublications.ki.se/Default.aspx?queryparsed=id:136541668 |
| Volume | 49 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV3dT9swELcGaNJeEPvuYMibxngho82Xk6cpdGVlYgx1gPpmOY7TRmsd1jRI7K_fXeJ2C92H1FRNfbVd-3y-y939TMgbJVPfTz1hxW3hWK4XSFhScWKJWPiukEzYaYX2eeb3L91PQ29oHrgVJqxyIRMrQZ3kEp-RH4KiESDwCwveX3-38NQo9K6aIzTWyAZClyFXs-HS4EK_ZZ0K56OdhG7KzTrNPDjUo3eYctrYjYxMXhtjSOSqvrkaNrn0nd7BGa32puMtsmmUShrVXPCQ3FP6EblfHzN5-5gUAzFTVOa4TdEbMI4x9oVmmp6fdj_aBzQ6OnEOqNAJvRj0Pts0M1Hmik4xXG80AR61qhQTUE_hdxqLsiqxZH6L9USTH2OVTdVsv6DG4_OEXB73Lrp9yxy2YEnWceeWTFhbJEy6MDvKZyFYUnYgVZCEbhogapcUbWHDlfp2R4YxC1MWemCKK8kSKVLnKVnXuVbPCYW7NBYxDjvOtxN3bOXbqZCxz2wlvRZ5uxh0Lg0SOR6IMeGVR9wJuB5xnJ0W1LUgvK7BN1ZJXuOscYSy0BgrMxJlUfCTL1c88kAfQeyevxJ9HTSI9g1RmkNvpDD5CfCfECKrQbnToIQFKRvFe8BByw4jfnc_OgVqkClTDjqR78PrpgPVLHiMG8FR8F9s3iKvlsXYAgbDaZWXSANaW-h6ttsiz2qWXLaGBrALKmaLsAazNrrTLNHZuIIVB8U-bDshtLtg69-6dXfU92p-b1T7IbuKeD4b8aIEi5LB-vsPXVlyB9ExGXDEH-jMV9_gk-IYBx06L_49ZtvkgY1qVxUDuEPW57NSvQSlcR7vVpIB3oNuZ5dsHPXOzgc_AcfWcEQ |
| linkProvider | ProQuest |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9MwELe2IQQvE98UBhhE2cvCWufDyQNCodtoWTdQ1017M47jtBVrOppmqPxR_I3c5aOQlY-nSa3U1lfbte_Od727nwl5qVXkOJEtjaAhTcOyXQUiFYSGDKRjScUlizK0z0OnfWx9OLVPV8iPshYG0ypLnZgp6nCi8D_ybTA0XAR-4e7b868G3hqF0dXyCo2cLfb1_Bu4bMmbzg7sb52xvd1-q20UtwoYijetmaFC3pAhVxZMQzvcA5eBuUq7oWdFLsJTKdmQDJ6Rw5rKC7gXcc8Gn1MrHioZmdDvKrlmmSCaWJneWqSUYJw0L71z0C_DsOh6XtbubseD11jiWjn9ijNgdYgpmMv27XKa5iJWewnXNDsL926R9cKIpX7OdbfJio7vkOv5tZbzuyTpyammaoLHIr0AZxxzbegopp-6rfdsi_rvOuYWlXFI-73dA0ZHRVa7pmNMDxycgUwYWUkLmMPwvRibRlkhy2yO_fhn34d6NNbTzYQWEaZ75PhKtuE-WYsnsX5IKLyLAhngsiN_mUGTaYdFUgUOZ1rZNfKqXHShCuRzvIDjTGQReNMV8UDg7tSgr5LwPAf7WCZ5gbsmEDojxtycgUyTRHQ-ngjfBvsHsYL-SnTUqxBtFkTRBGajZFEPAb8JIbkqlBsVSlAAqtJcBw5aTBjxwtt-F6hBh40F2GCOA4-LJnRT8pgoFFUifolVjTxfNOMImHwX60mKNGAlepbNrBp5kLPkYjR0uC0waWuEV5i1Mp1qSzwaZjDm4Eh4DdODcUu2_m1al1e9nvN7pdud0YkvJtOBSFLwYDnI33_o0lSYiMbJgSP-QFd89AVeaYF515756N9r9ozcaPcPuqLbOdx_TG4yNPmy_MMNsjabpvoJGKyz4GmmJSj5fNVq6SfXzaxc |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3rcxIxEM-0dXT80vEtWjU6Yr_0BHKP3H1wHIRisVg79DH9FnO5HNwIR-WgDv5p_nXu3gO94uNTZ2AGyJKEZHezy-7-QshLrULHCW1p-HVpGpbtKhApPzCkLx1LKi5ZmKJ9Hjh7J9aHM_tsjfwoamEwrbLQiamiDiYK_yOvgaHhIvALd2thnhZx2O68Pf9q4A1SGGktrtPIWGRfL76B-5a86bZhr6uMdXaPW3tGfsOAoXjDmhkq4HUZcGXBlLTDPXAfmKu0G3hW6CJUlZJ1yeAZOqyhPJ97Ifds8D-14oGSoQn9rpNr3OQuypjbWqaXYMw0K8Nz0EfDEOlmVuLu1uLBayx3LZ2E-XmwPsR0zFVbdzVlcxm3vYRxmp6LnVtkMzdoaTPjwNtkTcd3yPXsisvFXZL05VRTNcEjkl6AY455NzSK6WGv9Z7t0Oa7rrlDZRzQ4_7uR0ajPMNd0zGmCg5GIB9GWt4CpjF8L8amKC1qmS2wn-bo-1BHYz3dTmgebbpHTq5kG-6TjXgS64eEwrvQlz4uO_Ka6TeYdlgole9wppVdIa-KRRcqR0HHyzhGIo3Gm66IBwJ3pwJ9FYTnGfDHKskL3DWBMBoxMuRAzpNEdD-diqYNthDiBv2V6KhfItrOicIJzEbJvDYCfhPCc5Uot0qUoAxUqbkKHLScMGKH7zV7QA36bCzAHnMceFw0oJuCx0SutBLxS8Qq5PmyGUfARLxYT-ZIAxajZ9nMqpAHGUsuR0Pn2wLztkJ4iVlL0ym3xNEwhTQHp8Krmx6MW7D1b9O6vOrVjN9L3baj06aYTAcimYM3y0H-_kM3nwsTkTk5cMQf6PKPvsArLTAH2zMf_XvNnpEboJBEr3uw_5jcZGj9pamIW2RjNp3rJ2C7zvynqZKg5PNVa6Wf4WSwkg |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Rare+coding+variants+in+PLCG2%2C+ABI3%2C+and+TREM2+implicate+microglial-mediated+innate+immunity+in+Alzheimer%27s+disease&rft.jtitle=Nature+genetics&rft.au=Naj%2C+Adam+C&rft.au=Badarinarayan%2C+Nandini&rft.au=Vronskaya%2C+Maria&rft.au=Ruiz%2C+Agustin&rft.date=2017-09-01&rft.pub=Nature+Publishing+Group&rft.issn=1061-4036&rft.volume=49&rft.issue=9&rft.spage=1373&rft_id=info:doi/10.1038%2Fng.3916&rft.externalDBID=IOV&rft.externalDocID=A502334826 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1061-4036&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1061-4036&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1061-4036&client=summon |