Recruitment and Activation of RSK2 by HIV-1 Tat

• Published in: PloS one Vol. 2; no. 1; p. e151
• Main Authors: Hetzer, Claudia, Bisgrove, Dwayne, Cohen, Michael S., Pedal, Angelika, Kaehlcke, Katrin, Speyerer, Anja, Bartscherer, Kerstin, Taunton, Jack, Ott, Melanie
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 17.01.2007; Public Library of Science (PLoS)
• Subjects: Activation; Amino acids; Animals; Apoptosis; Biochemistry/Transcription and Translation; Cell Line; Chromatin; Coffin-Lowry syndrome; Coffin-Lowry Syndrome - enzymology; Coffin-Lowry Syndrome - genetics; Enzyme inhibitors; Event-related potentials; Gene Products, tat - genetics; Gene Products, tat - metabolism; Genes; Histones - metabolism; HIV; HIV Infections - genetics; HIV-1 - genetics; HIV-1 - metabolism; Human immunodeficiency virus; Humans; Immunology; Infectious Diseases/HIV Infection and AIDS; Kinases; Molecular Biology/Histone Modification; Mutation; Phosphorylation; Phosphotransferases; Proteins; Ribosomal protein S6 kinase; Ribosomal Protein S6 Kinases, 90-kDa - genetics; Ribosomal Protein S6 Kinases, 90-kDa - metabolism; RNA polymerase; Signal transduction; Tat protein; Terminal Repeat Sequences - genetics; Transcription; Transcription factors; Transcriptional Activation; Virology; Virology/Immunodeficiency Viruses; Virology/Viral and Gene Regulation; Virus Replication - genetics; United States > US; San Francisco California; California

The transcriptional activity of the integrated HIV provirus is dependent on the chromatin organization of the viral promoter and the transactivator Tat. Tat recruits the cellular pTEFb complex and interacts with several chromatin-modifying enzymes, including the histone acetyltransferases p300 and P...