Posterior cingulate γ-aminobutyric acid and glutamate/glutamine are reduced in amnestic mild cognitive impairment and are unrelated to amyloid deposition and apolipoprotein E genotype

• Published in: Neurobiology of aging Vol. 36; no. 1; pp. 53 - 59
• Main Authors: Riese, Florian, Gietl, Anton, Zölch, Niklaus, Henning, Anke, O’Gorman, Ruth, Kälin, Andrea M., Leh, Sandra E., Buck, Alfred, Warnock, Geoffrey, Edden, Richard A.E., Luechinger, Roger, Hock, Christoph, Kollias, Spyros, Michels, Lars
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2015
• Subjects: Aged; Aged, 80 and over; Alzheimer; Amyloid beta-Peptides - metabolism; APOE; Apolipoproteins E - genetics; Beta-amyloid; Cognitive Dysfunction - genetics; Cognitive Dysfunction - metabolism; Dementia; Female; GABA; gamma-Aminobutyric Acid - metabolism; Genotype; Glutamate; Glutamic Acid - metabolism; Glx; Gyrus Cinguli - metabolism; Humans; Internal Medicine; Magnetic resonance spectroscopy; Male; Mild cognitive impairment; MRS; Neurology; Neurotransmitter Agents - metabolism; PiB; Posterior cingulate cortex; Magnetic resonance spectroscopy; Glx; Mild cognitive impairment; Beta-amyloid; GABA; PiB; APOE; Glutamate; Alzheimer; Dementia; MRS; Posterior cingulate cortex

The biomarker potential of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) for the in vivo characterization of preclinical stages in Alzheimer's disease has not yet been explored. We measured GABA, glutamate + glutamine (Glx), and N-acetyl-aspartate (NAA) levels by single-voxel MEGA-...