Antipsychotic-induced vacuous chewing movements and extrapyramidal side effects are highly heritable in mice

• Published in: The pharmacogenomics journal Vol. 12; no. 2; pp. 147 - 155
• Main Authors: Crowley, J J, Adkins, D E, Pratt, A L, Quackenbush, C R, van den Oord, E J, Moy, S S, Wilhelmsen, K C, Cooper, T B, Bogue, M A, McLeod, H L, Sullivan, P F
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.04.2012; Nature Publishing Group
• Subjects: 692/699/375/346; 692/700/565/2194; Animal models; Animals; Antipsychotic Agents - adverse effects; Antipsychotic drugs; Antipsychotics; Biomedical and Life Sciences; Biomedicine; Chewing; Complications and side effects; Disease susceptibility; Extrapyramidal system; Factor analysis; Feasibility studies; Gene Expression; Gene mapping; Haloperidol; Haloperidol - adverse effects; Health aspects; Heritability; Human Genetics; Inbreeding; Male; Mastication; Mastication - drug effects; Mastication - genetics; Medicin och hälsovetenskap; Mental disorders; Mice; Mice, Inbred Strains; Movement disorders; Oncology; Open-field behavior; original-article; Pharmacogenomics; Pharmacotherapy; Phenotypes; Psychopharmacology; Psychotropic drugs; Schizophrenia; Tardive dyskinesia; United States; Sweden; haloperidol; vacuous chewing movements; antipsychotic; mouse model; adverse drug reaction; tardive dyskinesia

Pharmacogenomics is yet to fulfill its promise of manifestly altering clinical medicine. As one example, a predictive test for tardive dyskinesia (TD) (an adverse drug reaction consequent to antipsychotic exposure) could greatly improve the clinical treatment of schizophrenia but human studies are e...