Lymphatic mimicry in maternal endothelial cells promotes placental spiral artery remodeling

• Published in: The Journal of clinical investigation Vol. 129; no. 11; pp. 4912 - 4921
• Main Authors: Pawlak, John B, Bálint, László, Lim, Lillian, Ma, Wanshu, Davis, Reema B, Benyó, Zoltán, Soares, Michael J, Oliver, Guillermo, Kahn, Mark L, Jakus, Zoltán, Caron, Kathleen M
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 01.11.2019
• Subjects: Animals; Antigens, Differentiation; Arteries; Arteries - immunology; Arteries - pathology; Biomedical research; Cancer; Cell adhesion & migration; Endothelial cells; Endothelium; Endothelium, Lymphatic - immunology; Endothelium, Lymphatic - pathology; Extracellular matrix; Female; Fetal development; Fetal Growth Retardation - immunology; Fetal Growth Retardation - pathology; Fetuses; Gestation; Hormones; Humans; Kinases; Mice; Mimicry; Molecular Mimicry; Natural killer cells; Novels; Phosphorylation; Physiological aspects; Physiology; Placenta; Placenta - blood supply; Placenta - immunology; Placenta - pathology; Pre-eclampsia; Pre-Eclampsia - immunology; Pre-Eclampsia - pathology; Preeclampsia; Pregnancy; Pregnancy complications; Smooth muscle; Sunitinib; Uterus; Uterus - blood supply; Uterus - immunology; Uterus - pathology; Vascular endothelial growth factor; Vascular endothelial growth factor receptors; Vascular Remodeling - immunology; Veins & arteries; Mouse models; Reproductive biochemistry; Vascular Biology; Reproductive Biology; Lymph

Molecular heterogeneity of endothelial cells underlies their highly specialized functions during changing physiological conditions within diverse vascular beds. For example, placental spiral arteries (SAs) undergo remarkable remodeling to meet the ever-growing demands of the fetus - a process which...