Choosing preclinical study models of diabetic retinopathy: key problems for consideration

• Published in: Drug design, development and therapy Vol. 8; no. default; pp. 2311 - 2319
• Main Authors: Mi, Xuesong, Yuan, Ti-Fei, Zhong, Jing-Xiang, Ding, Yong, So, Kwok-Fai
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2014; Taylor & Francis Ltd; Dove Press; Dove Medical Press
• Subjects: Angiogenesis; animal model; Animal models; Animal models in research; Animals; Culture; Design of experiments; Design optimization; Diabetes; Diabetes mellitus; Diabetes Mellitus, Type 1 - complications; Diabetes Mellitus, Type 2 - complications; Diabetic retinopathy; Diabetic Retinopathy - complications; Diabetic Retinopathy - drug therapy; Disease Models, Animal; Edema; ex vivo culture; Experimental design; Eye surgery; Humans; Hyperglycemia; Hypotheses; in vitro culture; In vivo methods and tests; Medical imaging; Medical research; neurovascular dysfunction; Pathogenesis; Prevention; Researchers; Retina; Retinopathy; Review; Tumor necrosis factor-TNF; Vascular endothelial growth factor; Spain; Hong Kong; China; neurovascular dysfunction; ex vivo culture; animal model; in vitro culture

Diabetic retinopathy (DR) is the most common complication of diabetes mellitus in the eye. Although the clinical treatment for DR has already developed to a relative high level, there are still many urgent problems that need to be investigated in clinical and basic science. Currently, many in vivo a...