Biological features of novel avian influenza A (H7N9) virus

• Published in: Nature (London) Vol. 499; no. 7459; pp. 500 - 503
• Main Authors: Zhou, Jianfang, Wang, Dayan, Gao, Rongbao, Zhao, Baihui, Song, Jingdong, Qi, Xian, Zhang, Yanjun, Shi, Yonglin, Yang, Lei, Zhu, Wenfei, Bai, Tian, Qin, Kun, Lan, Yu, Zou, Shumei, Guo, Junfeng, Dong, Jie, Dong, Libo, Zhang, Ye, Wei, Hejiang, Li, Xiaodan, Lu, Jian, Liu, Liqi, Zhao, Xiang, Li, Xiyan, Huang, Weijuan, Wen, Leying, Bo, Hong, Xin, Li, Chen, Yongkun, Xu, Cuilin, Pei, Yuquan, Yang, Yue, Zhang, Xiaodong, Wang, Shiwen, Feng, Zijian, Han, Jun, Yang, Weizhong, Gao, George F., Wu, Guizhen, Li, Dexin, Wang, Yu, Shu, Yuelong
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 25.07.2013; Nature Publishing Group
• Subjects: 631/326/596/1578; Age; Analysis; Animals; Antibodies, Viral - immunology; Avian influenza; Avian influenza viruses; Biological complexity; Birds - virology; Bronchi - cytology; Bronchi - metabolism; Bronchi - virology; Cell Line; Chemokines; Chemokines - blood; China; Cross Reactions - immunology; Cytokines; Distribution; Epithelial Cells - virology; Glycoproteins; Health aspects; Host Specificity; Host-parasite relationships; Human populations; Humanities and Social Sciences; Humans; Identification and classification; In Vitro Techniques; Infections; Influenza A virus - immunology; Influenza A virus - pathogenicity; Influenza A virus - physiology; Influenza A Virus, H5N1 Subtype - immunology; Influenza A Virus, H5N1 Subtype - physiology; Influenza in Birds - transmission; Influenza in Birds - virology; Influenza Vaccines - immunology; Influenza, Human - blood; Influenza, Human - immunology; Influenza, Human - virology; letter; Lung - virology; multidisciplinary; N-Acetylneuraminic Acid - analogs & derivatives; N-Acetylneuraminic Acid - chemistry; N-Acetylneuraminic Acid - metabolism; Organ Specificity; Pandemics; Patient outcomes; Physiological aspects; Preferences; Properties; Protein binding; Public health; Pulmonary Alveoli - cytology; Pulmonary Alveoli - metabolism; Pulmonary Alveoli - virology; Receptors, Virus - chemistry; Receptors, Virus - metabolism; Respiratory tract; Science; Trachea - virology; Viral infections; Virus Replication; Viruses; Zoonoses; Zoonoses - transmission; Zoonoses - virology; China

An initial characterization of the receptor-binding properties of the novel avian influenza A (H7N9) shows that the virus has acquired the ability to bind human receptors while retaining the ability to bind avian receptors; the virus infects epithelial cells in the human lower respiratory tract and...