A randomized controlled experimental medicine study of ghrelin in value-based decision making

BACKGROUNDThe stomach-derived hormone ghrelin stimulates appetite, but the ghrelin receptor is also expressed in brain circuits involved in motivation and reward. We examined ghrelin effects on decision making beyond food or drug reward using monetary rewards.METHODSThirty participants (50% women an...

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Published inThe Journal of clinical investigation Vol. 133; no. 12; pp. 1 - 10
Main Authors Pietrzak, Michal, Yngve, Adam, Hamilton, J. Paul, Kämpe, Robin, Boehme, Rebecca, Asratian, Anna, Gauffin, Emelie, Löfberg, Andreas, Gustavson, Sarah, Persson, Emil, Capusan, Andrea J., Leggio, Lorenzo, Perini, Irene, Tinghög, Gustav, Heilig, Markus
Format Journal Article
LanguageEnglish
Published United States American Society for Clinical Investigation 15.06.2023
Subjects
Alcohol
Appetite
Aversion
Biological activity
Biomedical research
Brain mapping
Brain research
Clinical Medicine
Decision making
Feedback
Functional magnetic resonance imaging
Ghrelin
Growth hormones
Human experimentation in medicine
Hypothalamus
Metabolism
Neostriatum
Pharmacology, Experimental
Physiological aspects
Reinforcement
Reward (Psychology)
Self-experimentation in medicine
Testing
Sweden
Neuroendocrine regulation
Behavior
Addiction
Metabolism
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Abstract BACKGROUNDThe stomach-derived hormone ghrelin stimulates appetite, but the ghrelin receptor is also expressed in brain circuits involved in motivation and reward. We examined ghrelin effects on decision making beyond food or drug reward using monetary rewards.METHODSThirty participants (50% women and 50% men) underwent 2 fMRI scans while receiving i.v. ghrelin or saline in a randomized counterbalanced order.RESULTSStriatal representations of reward anticipation were unaffected by ghrelin, while activity during anticipation of losses was attenuated. Temporal discounting rates of monetary reward were lower overall in the ghrelin condition, an effect driven by women. Discounting rates were inversely correlated with neural activity in a large cluster within the left parietal lobule that included the angular gyrus. Activity in an overlapping cluster was related to behavioral choices and was suppressed by ghrelin.CONCLUSIONThis is, to our knowledge, the first human study to extend the understanding of ghrelin's significance beyond the canonical feeding domain or in relation to addictive substances. Contrary to our hypothesis, we found that ghrelin did not affect sensitivity to monetary reward anticipation, but rather resulted in attenuated loss aversion and lower discounting rates for these rewards. Ghrelin may cause a motivational shift toward caloric reward rather than globally promoting the value of reward.TRIAL REGISTRATIONEudraCT 2018-004829-82.FUNDINGSwedish Research Council (2013-07434), Marcus and Marianne Wallenberg foundation (2014.0187) and National Institute on Drug Abuse/National Institute on Alcohol Abuse and Alcoholism Intramural Research Program.
AbstractList BACKGROUND. The stomach-derived hormone ghrelin stimulates appetite, but the ghrelin receptor is also expressed in brain circuits involved in motivation and reward. We examined ghrelin effects on decision making beyond food or drug reward using monetary rewards. METHODS. Thirty participants (50% women and 50% men) underwent 2 fMRI scans while receiving i.v. ghrelin or saline in a randomized counterbalanced order. RESULTS. Striatal representations of reward anticipation were unaffected by ghrelin, while activity during anticipation of losses was attenuated. Temporal discounting rates of monetary reward were lower overall in the ghrelin condition, an effect driven by women. Discounting rates were inversely correlated with neural activity in a large cluster within the left parietal lobule that included the angular gyrus. Activity in an overlapping cluster was related to behavioral choices and was suppressed by ghrelin. CONCLUSION. This is, to our knowledge, the first human study to extend the understanding of ghrelins significance beyond the canonical feeding domain or in relation to addictive substances. Contrary to our hypothesis, we found that ghrelin did not affect sensitivity to monetary reward anticipation, but rather resulted in attenuated loss aversion and lower discounting rates for these rewards. Ghrelin may cause a motivational shift toward caloric reward rather than globally promoting the value of reward. TRIAL REGISTRATION. EudraCT 2018-004829-82.
BACKGROUND. The stomach-derived hormone ghrelin stimulates appetite, but the ghrelin receptor is also expressed in brain circuits involved in motivation and reward. We examined ghrelin effects on decision making beyond food or drug reward using monetary rewards. METHODS. Thirty participants (50% women and 50% men) underwent 2 fMRI scans while receiving i.v. ghrelin or saline in a randomized counterbalanced order. RESULTS. Striatal representations of reward anticipation were unaffected by ghrelin, while activity during anticipation of losses was attenuated. Temporal discounting rates of monetary reward were lower overall in the ghrelin condition, an effect driven by women. Discounting rates were inversely correlated with neural activity in a large cluster within the left parietal lobule that included the angular gyrus. Activity in an overlapping cluster was related to behavioral choices and was suppressed by ghrelin. CONCLUSION. This is, to our knowledge, the first human study to extend the understanding of ghrelin's significance beyond the canonical feeding domain or in relation to addictive substances. Contrary to our hypothesis, we found that ghrelin did not affect sensitivity to monetary reward anticipation, but rather resulted in attenuated loss aversion and lower discounting rates for these rewards. Ghrelin may cause a motivational shift toward caloric reward rather than globally promoting the value of reward.
BACKGROUND The stomach-derived hormone ghrelin stimulates appetite, but the ghrelin receptor is also expressed in brain circuits involved in motivation and reward. We examined ghrelin effects on decision making beyond food or drug reward using monetary rewards.METHODS Thirty participants (50% women and 50% men) underwent 2 fMRI scans while receiving i.v. ghrelin or saline in a randomized counterbalanced order.RESULTS Striatal representations of reward anticipation were unaffected by ghrelin, while activity during anticipation of losses was attenuated. Temporal discounting rates of monetary reward were lower overall in the ghrelin condition, an effect driven by women. Discounting rates were inversely correlated with neural activity in a large cluster within the left parietal lobule that included the angular gyrus. Activity in an overlapping cluster was related to behavioral choices and was suppressed by ghrelin.CONCLUSION This is, to our knowledge, the first human study to extend the understanding of ghrelin’s significance beyond the canonical feeding domain or in relation to addictive substances. Contrary to our hypothesis, we found that ghrelin did not affect sensitivity to monetary reward anticipation, but rather resulted in attenuated loss aversion and lower discounting rates for these rewards. Ghrelin may cause a motivational shift toward caloric reward rather than globally promoting the value of reward.TRIAL REGISTRATION EudraCT 2018-004829-82.FUNDING Swedish Research Council (2013-07434), Marcus and Marianne Wallenberg foundation (2014.0187) and National Institute on Drug Abuse/National Institute on Alcohol Abuse and Alcoholism Intramural Research Program.
TRIAL REGISTRATION. EudraCT 2018-004829-82.
BACKGROUNDThe stomach-derived hormone ghrelin stimulates appetite, but the ghrelin receptor is also expressed in brain circuits involved in motivation and reward. We examined ghrelin effects on decision making beyond food or drug reward using monetary rewards.METHODSThirty participants (50% women and 50% men) underwent 2 fMRI scans while receiving i.v. ghrelin or saline in a randomized counterbalanced order.RESULTSStriatal representations of reward anticipation were unaffected by ghrelin, while activity during anticipation of losses was attenuated. Temporal discounting rates of monetary reward were lower overall in the ghrelin condition, an effect driven by women. Discounting rates were inversely correlated with neural activity in a large cluster within the left parietal lobule that included the angular gyrus. Activity in an overlapping cluster was related to behavioral choices and was suppressed by ghrelin.CONCLUSIONThis is, to our knowledge, the first human study to extend the understanding of ghrelin's significance beyond the canonical feeding domain or in relation to addictive substances. Contrary to our hypothesis, we found that ghrelin did not affect sensitivity to monetary reward anticipation, but rather resulted in attenuated loss aversion and lower discounting rates for these rewards. Ghrelin may cause a motivational shift toward caloric reward rather than globally promoting the value of reward.TRIAL REGISTRATIONEudraCT 2018-004829-82.FUNDINGSwedish Research Council (2013-07434), Marcus and Marianne Wallenberg foundation (2014.0187) and National Institute on Drug Abuse/National Institute on Alcohol Abuse and Alcoholism Intramural Research Program.BACKGROUNDThe stomach-derived hormone ghrelin stimulates appetite, but the ghrelin receptor is also expressed in brain circuits involved in motivation and reward. We examined ghrelin effects on decision making beyond food or drug reward using monetary rewards.METHODSThirty participants (50% women and 50% men) underwent 2 fMRI scans while receiving i.v. ghrelin or saline in a randomized counterbalanced order.RESULTSStriatal representations of reward anticipation were unaffected by ghrelin, while activity during anticipation of losses was attenuated. Temporal discounting rates of monetary reward were lower overall in the ghrelin condition, an effect driven by women. Discounting rates were inversely correlated with neural activity in a large cluster within the left parietal lobule that included the angular gyrus. Activity in an overlapping cluster was related to behavioral choices and was suppressed by ghrelin.CONCLUSIONThis is, to our knowledge, the first human study to extend the understanding of ghrelin's significance beyond the canonical feeding domain or in relation to addictive substances. Contrary to our hypothesis, we found that ghrelin did not affect sensitivity to monetary reward anticipation, but rather resulted in attenuated loss aversion and lower discounting rates for these rewards. Ghrelin may cause a motivational shift toward caloric reward rather than globally promoting the value of reward.TRIAL REGISTRATIONEudraCT 2018-004829-82.FUNDINGSwedish Research Council (2013-07434), Marcus and Marianne Wallenberg foundation (2014.0187) and National Institute on Drug Abuse/National Institute on Alcohol Abuse and Alcoholism Intramural Research Program.
BACKGROUNDThe stomach-derived hormone ghrelin stimulates appetite, but the ghrelin receptor is also expressed in brain circuits involved in motivation and reward. We examined ghrelin effects on decision making beyond food or drug reward using monetary rewards.METHODSThirty participants (50% women and 50% men) underwent 2 fMRI scans while receiving i.v. ghrelin or saline in a randomized counterbalanced order.RESULTSStriatal representations of reward anticipation were unaffected by ghrelin, while activity during anticipation of losses was attenuated. Temporal discounting rates of monetary reward were lower overall in the ghrelin condition, an effect driven by women. Discounting rates were inversely correlated with neural activity in a large cluster within the left parietal lobule that included the angular gyrus. Activity in an overlapping cluster was related to behavioral choices and was suppressed by ghrelin.CONCLUSIONThis is, to our knowledge, the first human study to extend the understanding of ghrelin's significance beyond the canonical feeding domain or in relation to addictive substances. Contrary to our hypothesis, we found that ghrelin did not affect sensitivity to monetary reward anticipation, but rather resulted in attenuated loss aversion and lower discounting rates for these rewards. Ghrelin may cause a motivational shift toward caloric reward rather than globally promoting the value of reward.TRIAL REGISTRATIONEudraCT 2018-004829-82.FUNDINGSwedish Research Council (2013-07434), Marcus and Marianne Wallenberg foundation (2014.0187) and National Institute on Drug Abuse/National Institute on Alcohol Abuse and Alcoholism Intramural Research Program.
Audience Academic
Author Gauffin, Emelie
Heilig, Markus
Löfberg, Andreas
Kämpe, Robin
Leggio, Lorenzo
Gustavson, Sarah
Boehme, Rebecca
Asratian, Anna
Tinghög, Gustav
Pietrzak, Michal
Capusan, Andrea J.
Perini, Irene
Yngve, Adam
Hamilton, J. Paul
Persson, Emil
AuthorAffiliation 3 Center for Medical Imaging and Visualization and
2 Department of Psychiatry, Linköping University Hospital, Linköping, Sweden
1 Center for Social and Affective Neuroscience, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden
4 Division of Economics, Department of Management and Engineering, Linköping University, Linköping, Sweden
6 National Center for Health Care Priority Setting, Department of Health Medicine and Caring Sciences, Linköping University, Linköping, Sweden
5 Section on Clinical Psychoneuroendocrinology and Neuropsychopharmacology, Translational Addiction Medicine Branch, National Institute on Drug Abuse Intramural Research Program and National Institute on Alcohol Abuse and Alcoholism, Division of Intramural Clinical and Biological Research, National Institutes of Health, Baltimore, Maryland, USA
AuthorAffiliation_xml – name: 3 Center for Medical Imaging and Visualization and
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– name: 5 Section on Clinical Psychoneuroendocrinology and Neuropsychopharmacology, Translational Addiction Medicine Branch, National Institute on Drug Abuse Intramural Research Program and National Institute on Alcohol Abuse and Alcoholism, Division of Intramural Clinical and Biological Research, National Institutes of Health, Baltimore, Maryland, USA
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Cites_doi 10.1016/bs.irn.2017.08.002
10.1073/pnas.1018033108
10.1016/j.tins.2021.01.006
10.1073/pnas.1614961114
10.1007/s00213-006-0686-7
10.1006/cbmr.1996.0014
10.1093/scan/nsz077
10.1016/j.biopsych.2014.03.019
10.1098/rspb.1998.0534
10.3389/fendo.2022.904754
10.1016/j.neuroimage.2014.06.027
10.1002/hec.3933
10.1073/pnas.0812809106
10.1093/alcalc/agx082
10.1146/annurev-physiol-021113-170310
10.1210/jc.2002-021504
10.1177/1073858417735514
10.1126/science.1100907
10.1016/j.neulet.2011.05.034
10.1038/mp.2017.226
10.1503/jpn.190031
10.1016/j.biopsych.2014.12.022
10.1016/j.celrep.2018.11.026
10.1210/jc.2012-4247
10.1523/JNEUROSCI.3446-06.2006
10.1172/JCI29867
10.3758/CABN.7.1.1
10.1523/JNEUROSCI.2058-08.2008
10.1038/nrn2357
10.1016/j.mce.2011.02.017
10.1038/npp.2015.297
10.1210/jcem.86.12.8111
10.1016/j.physbeh.2019.02.008
10.1038/nrn3105
10.1016/j.addbeh.2013.10.033
10.1016/j.molmet.2015.03.005
10.1016/j.biopsycho.2018.10.011
10.1152/physrev.00014.2018
10.1016/j.neuroimage.2008.11.004
10.1089/brain.2016.0475
10.1210/jc.2005-2638
10.1002/hbm.24184
10.1016/B978-0-444-63622-5.00020-6
10.1017/S1930297500004812
10.1177/1073858412440596
10.1523/JNEUROSCI.21-16-j0002.2001
10.1371/journal.pone.0255292
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Copyright American Society for Clinical Investigation Jun 2023
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Issue 12
Keywords Neuroendocrine regulation
Behavior
Addiction
Metabolism
Language English
License http://creativecommons.org/licenses/by/4.0
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Authorship note: MP, AY, GT, and MH contributed equally to this work.
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B27
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Cox (B46) 2017; 114
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References_xml – ident: B4
  doi: 10.1016/bs.irn.2017.08.002
– ident: B7
  doi: 10.1073/pnas.1018033108
– ident: B23
  doi: 10.1016/j.tins.2021.01.006
– volume: 114
  start-page: 3370
  issue: 17
  year: 2017
  ident: B46
  article-title: fMRI clustering and false-positive rates
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1614961114
– ident: B19
  doi: 10.1007/s00213-006-0686-7
– ident: B44
  doi: 10.1006/cbmr.1996.0014
– ident: B32
  doi: 10.1093/scan/nsz077
– ident: B13
  doi: 10.1016/j.biopsych.2014.03.019
– ident: B38
  doi: 10.1098/rspb.1998.0534
– ident: B40
  doi: 10.3389/fendo.2022.904754
– ident: B47
  doi: 10.1016/j.neuroimage.2014.06.027
– ident: B9
  doi: 10.1002/hec.3933
– ident: B5
  doi: 10.1073/pnas.0812809106
– ident: B11
  doi: 10.1093/alcalc/agx082
– ident: B27
  doi: 10.1146/annurev-physiol-021113-170310
– ident: B41
  doi: 10.1210/jc.2002-021504
– ident: B24
  doi: 10.1177/1073858417735514
– ident: B34
  doi: 10.1126/science.1100907
– ident: B30
  doi: 10.1016/j.neulet.2011.05.034
– ident: B14
  doi: 10.1038/mp.2017.226
– volume: 45
  start-page: 253
  issue: 4
  year: 2020
  ident: B33
  article-title: Metabolic state and value-based decision-making in acute and recovered female patients with anorexia nervosa
  publication-title: J Psychiatry Neurosci
  doi: 10.1503/jpn.190031
– ident: B43
  doi: 10.1016/j.biopsych.2014.12.022
– ident: B25
  doi: 10.1016/j.celrep.2018.11.026
– ident: B12
  doi: 10.1210/jc.2012-4247
– ident: B20
  doi: 10.1523/JNEUROSCI.3446-06.2006
– ident: B28
  doi: 10.1172/JCI29867
– ident: B36
  doi: 10.3758/CABN.7.1.1
– ident: B18
  doi: 10.1523/JNEUROSCI.2058-08.2008
– ident: B6
  doi: 10.1038/nrn2357
– ident: B26
  doi: 10.1016/j.mce.2011.02.017
– ident: B10
  doi: 10.1038/npp.2015.297
– ident: B21
  doi: 10.1210/jcem.86.12.8111
– ident: B3
  doi: 10.1016/j.physbeh.2019.02.008
– ident: B2
  doi: 10.1038/nrn3105
– ident: B39
  doi: 10.1016/j.addbeh.2013.10.033
– ident: B1
  doi: 10.1016/j.molmet.2015.03.005
– ident: B31
  doi: 10.1016/j.biopsycho.2018.10.011
– ident: B29
  doi: 10.1152/physrev.00014.2018
– ident: B35
  doi: 10.1016/j.neuroimage.2008.11.004
– ident: B45
  doi: 10.1089/brain.2016.0475
– ident: B42
  doi: 10.1210/jc.2005-2638
– ident: B17
  doi: 10.1002/hbm.24184
– ident: B37
  doi: 10.1016/B978-0-444-63622-5.00020-6
– ident: B8
  doi: 10.1017/S1930297500004812
– ident: B22
  doi: 10.1177/1073858412440596
– ident: B15
  doi: 10.1523/JNEUROSCI.21-16-j0002.2001
– ident: B16
  doi: 10.1371/journal.pone.0255292
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Snippet BACKGROUNDThe stomach-derived hormone ghrelin stimulates appetite, but the ghrelin receptor is also expressed in brain circuits involved in motivation and...
BACKGROUND. The stomach-derived hormone ghrelin stimulates appetite, but the ghrelin receptor is also expressed in brain circuits involved in motivation and...
TRIAL REGISTRATION. EudraCT 2018-004829-82.
BACKGROUND The stomach-derived hormone ghrelin stimulates appetite, but the ghrelin receptor is also expressed in brain circuits involved in motivation and...
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SubjectTerms Alcohol
Appetite
Aversion
Biological activity
Biomedical research
Brain mapping
Brain research
Clinical Medicine
Decision making
Feedback
Functional magnetic resonance imaging
Ghrelin
Growth hormones
Human experimentation in medicine
Hypothalamus
Metabolism
Neostriatum
Pharmacology, Experimental
Physiological aspects
Reinforcement
Reward (Psychology)
Self-experimentation in medicine
Testing
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Title A randomized controlled experimental medicine study of ghrelin in value-based decision making
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