Epithelial‐mesenchymal transition spectrum quantification and its efficacy in deciphering survival and drug responses of cancer patients

• Published in: EMBO molecular medicine Vol. 6; no. 10; pp. 1279 - 1293
• Main Authors: Tan, Tuan Zea, Miow, Qing Hao, Miki, Yoshio, Noda, Tetsuo, Mori, Seiichi, Huang, Ruby Yun‐Ju, Thiery, Jean Paul
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.10.2014; John Wiley & Sons, Inc; EMBO Press; BlackWell Publishing Ltd; Springer Nature
• Subjects: Antineoplastic Agents - therapeutic use; Breast; Breast cancer; Breast carcinoma; Breast Neoplasms - drug therapy; Breast Neoplasms - genetics; Cancer patients; Cancer therapies; Cell Line, Tumor; Chemotherapy; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - drug therapy; Colorectal Neoplasms - genetics; Development and progression; Disease-Free Survival; drug response; Drug therapy; EMBO02; EMBO03; Epithelial-Mesenchymal Transition - drug effects; Epithelial-Mesenchymal Transition - genetics; epithelial‐mesenchymal transition; Female; Gastric cancer; Gene expression; Gene Expression Regulation, Neoplastic - drug effects; gene expression signature; Genomes; Genotype & phenotype; Humans; Kinases; Lung Neoplasms - drug therapy; Lung Neoplasms - genetics; Mesenchyme; Metastases; Metastasis; microarray; Neoplasms - drug therapy; Neoplasms - genetics; Oligonucleotide Array Sequence Analysis; Ovarian cancer; Ovarian Neoplasms - drug therapy; Ovarian Neoplasms - genetics; Paclitaxel; Patient outcomes; prognosis; Research Article; Software; Stem cells; Stomach cancer; Stomach Neoplasms - drug therapy; Stomach Neoplasms - genetics; Transcriptome - drug effects; Transcriptome - genetics; Treatment Outcome; Tumors; Urinary Bladder Neoplasms - drug therapy; Urinary Bladder Neoplasms - genetics; Singapore; drug response; microarray; gene expression signature; epithelial‐mesenchymal transition; prognosis

Epithelial‐mesenchymal transition (EMT) is a reversible and dynamic process hypothesized to be co‐opted by carcinoma during invasion and metastasis. Yet, there is still no quantitative measure to assess the interplay between EMT and cancer progression. Here, we derived a method for universal EMT sco...