Specific roles for dendritic cell subsets during initiation and progression of psoriasis

• Published in: EMBO molecular medicine Vol. 6; no. 10; pp. 1312 - 1327
• Main Authors: Glitzner, Elisabeth, Korosec, Ana, Brunner, Patrick M, Drobits, Barbara, Amberg, Nicole, Schonthaler, Helia B, Kopp, Tamara, Wagner, Erwin F, Stingl, Georg, Holcmann, Martin, Sibilia, Maria
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.10.2014; John Wiley & Sons, Inc; EMBO Press; BlackWell Publishing Ltd; Springer Nature
• Subjects: Adjuvants, Immunologic - pharmacology; Aminoquinolines - pharmacology; Analysis; Animals; Antibodies, Monoclonal - immunology; Antibodies, Monoclonal - pharmacology; Antigen-Presenting Cells - immunology; Antigen-Presenting Cells - metabolism; AP‐1; Bone marrow; Bone Marrow Transplantation; Dendritic cells; Dendritic Cells - immunology; Dendritic Cells - metabolism; Development and progression; Disease Progression; EMBO19; EMBO38; Etiology; Experiments; Flow Cytometry; Humans; IL‐23; Inflammation; Interleukin-10 - immunology; Interleukin-10 - metabolism; Interleukin-23 - immunology; Interleukin-23 - metabolism; Langerhans cells; Langerhans Cells - immunology; Langerhans Cells - metabolism; Lymphocytes; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Confocal; Patients; Phenotypes; plasmacytoid dendritic cells; Proto-Oncogene Proteins c-jun - deficiency; Proto-Oncogene Proteins c-jun - genetics; Proto-Oncogene Proteins c-jun - immunology; Psoriasis; Psoriasis - genetics; Psoriasis - immunology; Psoriasis - prevention & control; Receptors, Interleukin - immunology; Receptors, Interleukin - metabolism; Research Article; Roles; Signal Transduction - drug effects; Signal Transduction - immunology; Skin - drug effects; Skin - immunology; Skin - pathology; Transcription Factors - deficiency; Transcription Factors - genetics; Transcription Factors - immunology; Langerhans cells; IL‐23; AP‐1; plasmacytoid dendritic cells; psoriasis

Several subtypes of APCs are found in psoriasis patients, but their involvement in disease pathogenesis is poorly understood. Here, we investigated the contribution of Langerhans cells (LCs) and plasmacytoid DCs (pDCs) in psoriasis. In human psoriatic lesions and in a psoriasis mouse model (DKO* mic...