A largely random AAV integration profile after LPLD gene therapy - Kaeppel, Christine; Beattie, Stuart G; Fronza, Raffaele; van Logtenstein, Richard; Salmon, Florence; Schmidt, Sabine; Wolf, Stephan; Nowrouzi, Ali; Glimm, Hanno; von Kalle, Christof; Petry, Harald; Gaudet, Daniel; et al. (Nature medicine, 2013)
Keywords: 692/308/575; Adeno-associated virus; Adenoviruses; Analysis; Animals; Binding Sites - genetics; Biomedicine; Biotechnology industry; brief-communication; Cancer Research; Clinical trials; Dependovirus - genetics; Dependovirus - physiology; Dependoviruses; Gene therapy; Genetic aspects; Genetic Therapy - adverse effects; Genetic vectors; Genetic Vectors - administration & dosage; Genetic Vectors - adverse effects; Genetic Vectors - genetics; Genetic Vectors - physiology; Health aspects; Humans; Hyperlipoproteinemia Type I - genetics; Infectious Diseases; Injection; Injections, Intramuscular; Lipoprotein lipase; Lipoprotein Lipase - administration & dosage; Lipoprotein Lipase - deficiency; Lipoprotein Lipase - genetics; Metabolic Diseases; Mice; Mice, Inbred C57BL; Models, Biological; Molecular Medicine; Mutagenesis, Insertional - genetics; Mutagenesis, Insertional - physiology; Neurosciences; Physiological aspects; Transcriptome; Virus Integration - genetics; Virus Integration - physiology; Canada