A novel combined adjuvant for nasal delivery elicits mucosal immunity to influenza in aging - Asanuma, Hideki; Zamri, Normaiza Binti; Sekine, Shinichi; Fukuyama, Yoshiko; Tokuhara, Daisuke; Gilbert, Rebekah S.; Fukuiwa, Tatsuya; Fujihashi, Keiko; Sata, Tetsutaro; Tashiro, Masato; Fujihashi, Kohtaro (Vaccine, 2012)
Keywords: Adenoviruses; Adjuvants, Immunologic - administration & dosage; Administration, Intranasal; adults; Age; Aged mice; Aging; Allergy and Immunology; Animals; Antibodies, Viral - immunology; Cytokines; Dendritic Cells - immunology; Drug dosages; Experiments; Female; Hemagglutinin Glycoproteins, Influenza Virus - administration & dosage; Hemagglutinin Glycoproteins, Influenza Virus - immunology; hemagglutinins; Immunity, Mucosal; immunoglobulin A; Immunoglobulin A - immunology; Infectious diseases; Influenza; Influenza A virus - immunology; Influenza A virus - pathogenicity; Influenza Vaccines - administration & dosage; Influenza Vaccines - immunology; Ligands; lymph nodes; Medical research; Membrane Proteins - administration & dosage; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mortality; mucosal immunity; Mucosal vaccine; nasal cavity; Oligodeoxyribonucleotides - administration & dosage; Orthomyxoviridae Infections - immunology; Orthomyxoviridae Infections - prevention & control; Plasma; plasmids; Respiratory tract; Streptococcus infections; Th1 Cells - immunology; Th2 Cells - immunology; Vaccines; viruses; Aged mice; Mucosal vaccine; Influenza; DC