A Visible-Light-Mediated Radical Smiles Rearrangement and its Application to the Synthesis of a Difluoro-Substituted Spirocyclic ORL-1 Antagonist - Douglas, James J.; Albright, Haley; Sevrin, Martin J.; Cole, Kevin P.; Stephenson, Corey R. J. (Angewandte Chemie International Edition, 2015)
Keywords: catalysis; Catalysts; Chemistry; Chemistry, Multidisciplinary; Free Radicals - chemistry; Free Radicals - radiation effects; heterocycles; Heterocyclic Compounds - chemical synthesis; Heterocyclic Compounds - chemistry; Heterocyclic Compounds - pharmacology; Light; Molecular Structure; Nociceptin Receptor; Opioid receptors; photocatalysis; Photochemicals; Physical Sciences; radical reactions; rearrangement; Receptors, Opioid - metabolism; Science & Technology; Spiro Compounds - chemical synthesis; Spiro Compounds - chemistry; Spiro Compounds - pharmacology; Synthesis; ACTIVATION; COMPLEX; radical reactions; catalysis; COPPER; FLUORINATION; PHOTOREDOX CATALYSIS; DIFLUOROMETHYLATION; heterocycles; BONDS; OLEFINS; ALKENYL; photocatalysis; rearrangement