Therapeutic effects of serum extracellular vesicles in liver fibrosis

• Published in: Journal of extracellular vesicles Vol. 7; no. 1; pp. 1461505 - n/a
• Main Authors: Chen, Li, Chen, Ruju, Kemper, Sherri, Cong, Min, You, Hong, Brigstock, David R.
• Format: Journal Article
• Language: English
• Published: Sweden Taylor & Francis 01.12.2018; John Wiley & Sons, Inc; Wiley
• Subjects: Actin; Alanine transaminase; Alcohol; Animal models; anti-fibrotic therapy; Aspartate aminotransferase; Blood & organ donations; Body fluids; Carbon; Carbon tetrachloride; Cell activation; Cell proliferation; Chromosome 5; Chronic illnesses; Connective tissue growth factor; Connective tissues; Cytokines; Ethanol; Exosome; Extracellular vesicles; Females; fibrogenesis; Fibrosis; Gene expression; Growth factors; hepatic stellate cell; Hepatitis; hepatocyte; Hepatocytes; Hepatology; Hospitals; Immunohistochemistry; Inflammation; Kinases; Lipids; Liver cancer; Liver cirrhosis; Liver diseases; Metastases; microRNA; MicroRNAs; miRNA; Monocytes; Phenotypes; Polyacrylamide; Polymerase chain reaction; Proteins; Rodents; Smooth muscle; Stellate cells; Transforming growth factor-b; Transmission electron microscopy; Beijing China; China; anti-fibrotic therapy; hepatocyte; Exosome; microRNA; fibrosis; hepatic stellate cell; fibrogenesis

The lack of approved therapies for hepatic fibrosis seriously limits medical management of patients with chronic liver disease. Since extracellular vesicles (EVs) function as conduits for intercellular molecular transfer, we investigated if EVs from healthy individuals have anti-fibrotic properties....