RNA-sequencing of the brain transcriptome implicates dysregulation of neuroplasticity, circadian rhythms and GTPase binding in bipolar disorder

• Published in: Molecular psychiatry Vol. 19; no. 11; pp. 1179 - 1185
• Main Authors: Akula, N, Barb, J, Jiang, X, Wendland, J R, Choi, K H, Sen, S K, Hou, L, Chen, D T W, Laje, G, Johnson, K, Lipska, B K, Kleinman, J E, Corrada-Bravo, H, Detera-Wadleigh, S, Munson, P J, McMahon, F J
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.11.2014; Nature Publishing Group
• Subjects: 631/337/2019; 631/378/1385; 692/699/476/1333; Adult; Aged; Behavioral Sciences; Bioinformatics; Biological Psychology; Bipolar disorder; Bipolar Disorder - genetics; Bipolar Disorder - metabolism; Brain; Brain research; Circadian rhythm; Circadian Rhythm - genetics; Circadian Rhythm - physiology; Circadian rhythms; DNA microarrays; Female; Gender; Gene expression; Genetic aspects; Genetic research; Genome-wide association studies; Genome-Wide Association Study; Genomes; GTP Phosphohydrolases - genetics; GTP Phosphohydrolases - metabolism; Humans; Independent sample; Information technology; Male; Medicine; Medicine & Public Health; Mental health; Meta-Analysis as Topic; Methods; Microarray Analysis; Middle Aged; Neuronal Plasticity - genetics; Neuronal Plasticity - physiology; Neuroplasticity; Neurosciences; Non-coding RNA; Ontology; original-article; Pharmacotherapy; Polymerase Chain Reaction; Prefrontal cortex; Prefrontal Cortex - metabolism; Principal Component Analysis; Psychiatry; Ribonucleic acid; RNA; RNA sequencing; Sequence Analysis, RNA - methods; Single-nucleotide polymorphism; Splicing factors; Transcriptome; Transcriptomes; Young Adult; United States > US; long noncoding RNAs; genome-wide association studies; gene expression; Gene Ontology; microarrays

RNA-sequencing (RNA-seq) is a powerful technique to investigate the complexity of gene expression in the human brain. We used RNA-seq to survey the brain transcriptome in high-quality postmortem dorsolateral prefrontal cortex from 11 individuals diagnosed with bipolar disorder (BD) and from 11 age-...