Alterations of GABA and glutamate–glutamine levels in premenstrual dysphoric disorder: A 3T proton magnetic resonance spectroscopy study

• Published in: Psychiatry research. Neuroimaging Vol. 231; no. 1; pp. 64 - 70
• Main Authors: Liu, Bo, Wang, Guangbin, Gao, Dongmei, Gao, Fei, Zhao, Bin, Qiao, Mingqi, Yang, Huan, Yu, Yanhong, Ren, Fuxin, Yang, Ping, Chen, Weibo, Rae, Caroline D.
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 30.01.2015
• Subjects: Adult; Analysis of Variance; Case-Control Studies; Female; GABA; gamma-Aminobutyric Acid - metabolism; Glutamates - metabolism; Glutamate–glutamine; Glutamine - metabolism; Gyrus Cinguli - physiopathology; Humans; Luteal Phase - physiology; Luteal Phase - psychology; Menstrual Cycle - physiology; Prefrontal Cortex - physiopathology; Premenstrual Dysphoric Disorder - metabolism; Premenstrual Dysphoric Disorder - pathology; Premenstrual dysphoric syndrome; Proton magnetic resonance spectroscopy; Proton Magnetic Resonance Spectroscopy - methods; Psychiatry; Radiology; GABA; Proton magnetic resonance spectroscopy; Glutamate–glutamine; Premenstrual dysphoric syndrome

Increasing evidence has suggested that the GABAergic neurotransmitter system is involved in the pathogenesis of premenstrual dysphoric disorder (PMDD). We used proton magnetic resonance spectroscopy (1H MRS) to investigate whether PMDD is associated with alterations in brain GABA levels. Levels of g...