The DNA sequence of the human X chromosome

• Published in: Nature (London) Vol. 434; no. 7031; pp. 325 - 337
• Main Authors: Coffey, Alison J., McLay, Kirsten, Howell, Gareth R., Bird, Christine P., Frankish, Adam, Fulton, Robert S., Sudbrak, Ralf, Andrews, T. Daniel, Searle, Stephen, Whittaker, Adam, Carter, Nigel P., Hodgson, Anne, Richards, Stephen, Steffen, David, Sodergren, Erica, Ainscough, Rachael, Barker, Gary E., Beasley, Helen, Blechschmidt, Karin, Brown, Andrew J., Brown, Mary J., Bonnin, David, Buhay, Christian, Burch, Paula, Burgess, Joanne, Carrel, Laura, Chako, Joseph, Chavez, Dean, Chen, Ellson, Chen, Yuan, Chinault, Craig, Ciccodicola, Alfredo, Conquer, Jen S., David, Robert, Davis, John, DeShazo, Denise, Dhami, Pawandeep, Dugan-Rocha, Shannon, Dunn, Matthew, Ellwood, Matthew, Faulkner, Louisa, Francis, Fiona, Hamilton, Cerissa, Hoffs, Michael, Huckle, Elizabeth J., de Jong, Pieter J., Joseph, Shirin S., Keenan, Stephen, Khan, Ziad, Laird, Gavin K., Lewis, Lora, Liu, Wen, Lozado, Ryan, McDowall, Jennifer, McMurray, Amanda, Mistry, Shailesh L., Morgan, Margaret, Morris, Sidney, Müller, Ines, Mullikin, James C., Nyakatura, Gerald, O'Dell, Christopher N., Palmer, Sophie, Pandian, Richard, Parker, David, Parrish, Julia, Pasternak, Shiran, Pearce, Alex V., Pearson, Danita M., Perez, Lesette, Porter, Keith M., Schlessinger, David, Shen, Hua, Sheridan, Elizabeth M., Skuce, Carl D., Sotheran, Elizabeth C., Swann, R. Mark, Swarbreck, David, Tabor, Paul E., Taylor, Tineace, Teague, Brian, Trevanion, Steve, Tromans, Anthony C., d'Urso, Michele, Villasana, Donna, Wall, Melanie, Warren, James, Williams, Leanne, Woodmansey, Rebecca L., Yen, Jennifer, Poustka, Annemarie, Rosenthal, André, Minx, Patrick J., Willard, Huntington F., Wilson, Richard K., Vaudin, Mark, Coulson, Alan, Durbin, Richard, Hubbard, Tim, Bentley, David R.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 17.03.2005; Nature Publishing; Nature Publishing Group
• Subjects: Animals; Antigens, Neoplasm - genetics; Biological and medical sciences; Centromere - genetics; Chromatin. Chromosome; Chromosomes; Chromosomes, Human, X - genetics; Chromosomes, Human, Y - genetics; Contig Mapping; Crossing Over, Genetic - genetics; Deoxyribonucleic acid; DNA; Dosage Compensation, Genetic; Evolution, Molecular; Female; Fundamental and applied biological sciences. Psychology; Genetic Linkage - genetics; Genetics, Medical; Genomics; Human subjects; Humanities and Social Sciences; Humans; Inactivation; Male; Molecular and cellular biology; Molecular genetics; multidisciplinary; Polymorphism, Single Nucleotide - genetics; Quantitative genetics; Repetitive Sequences, Nucleic Acid - genetics; RNA - genetics; Science; Science (multidisciplinary); Sequence Analysis, DNA; Sequence Homology, Nucleic Acid; Testis - metabolism; Human; Molecular evolution; X-Chromosome; DNA; Sex chromosome

The human X chromosome has a unique biology that was shaped by its evolution as the sex chromosome shared by males and females. We have determined 99.3% of the euchromatic sequence of the X chromosome. Our analysis illustrates the autosomal origin of the mammalian sex chromosomes, the stepwise proce...