Imaging the accumulation and suppression of tau pathology using multiparametric MRI

• Published in: Neurobiology of aging Vol. 39; pp. 184 - 194
• Main Authors: Holmes, Holly E., Colgan, Niall, Ismail, Ozama, Ma, Da, Powell, Nick M., O'Callaghan, James M., Harrison, Ian F., Johnson, Ross A., Murray, Tracey K., Ahmed, Zeshan, Heggenes, Morton, Fisher, Alice, Cardoso, M.J., Modat, Marc, Walker-Samuel, Simon, Fisher, Elizabeth M.C., Ourselin, Sebastien, O'Neill, Michael J., Wells, Jack A., Collins, Emily C., Lythgoe, Mark F.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2016; Elsevier
• Subjects: Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Alzheimer's disease; Animals; Atrophy - genetics; Biomarker; Cerebral Cortex - pathology; Disease Models, Animal; Doxycycline - pharmacology; Female; Hippocampus - pathology; Internal Medicine; In vivo; Longitudinal; Longitudinal Studies; Magnetic Resonance Imaging - methods; Male; Mice, Transgenic; MRI; Neurofibrillary Tangles - pathology; Neurology; Regular; tau Proteins - genetics; tau Proteins - metabolism; Tauopathies - pathology; Tauopathy; Transgenes - drug effects; Biomarker; Longitudinal; Tauopathy; MRI; Alzheimer's disease; In vivo

Mouse models of Alzheimer's disease have served as valuable tools for investigating pathogenic mechanisms relating to neurodegeneration, including tau-mediated and neurofibrillary tangle pathology—a major hallmark of the disease. In this work, we have used multiparametric magnetic resonance ima...