Distinctive transcriptome alterations of prefrontal pyramidal neurons in schizophrenia and schizoaffective disorder

• Published in: Molecular psychiatry Vol. 20; no. 11; pp. 1397 - 1405
• Main Authors: Arion, D, Corradi, J P, Tang, S, Datta, D, Boothe, F, He, A, Cacace, A M, Zaczek, R, Albright, C F, Tseng, G, Lewis, D A
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.11.2015; Nature Publishing Group
• Subjects: 38/61; 692/699/476/1799; Adult; Analysis; Analysis of Variance; Animals; Antipsychotic Agents - pharmacology; Behavioral Sciences; Biological Psychology; Diagnosis; DNA microarrays; Female; Gene expression; Gene Expression Profiling; Gene Expression Regulation - drug effects; Gene Expression Regulation - physiology; Genetic aspects; Humans; Laser Capture Microdissection; Lasers; Macaca fascicularis; Male; Medicine; Medicine & Public Health; Memory; Mental disorders; Middle Aged; Mitochondria; Mitochondrial Proteins - genetics; Mitochondrial Proteins - metabolism; Neurons; Neurosciences; Oligonucleotide Array Sequence Analysis; original-article; Pharmacotherapy; Phenotypes; Physiological aspects; Prefrontal cortex; Prefrontal Cortex - drug effects; Prefrontal Cortex - pathology; Proteasomes; Psychiatry; Psychotic Disorders - pathology; Pyramidal cells; Pyramidal Cells - metabolism; Risk factors; RNA, Messenger - metabolism; Schizoaffective disorder; Schizoaffective disorders; Schizophrenia; Schizophrenia - pathology; Short term memory; Signal Transduction - drug effects; Signal Transduction - physiology; Substantia grisea; Transcription; Transcriptome - physiology; Ubiquitin; Ubiquitin - genetics; Ubiquitin - metabolism; United States; United States > US; Pittsburgh Pennsylvania

Schizophrenia is associated with alterations in working memory that reflect dysfunction of dorsolateral prefrontal cortex (DLPFC) circuitry. Working memory depends on the activity of excitatory pyramidal cells in DLPFC layer 3 and, to a lesser extent, in layer 5. Although many studies have profiled...