Casein phosphopeptide-amorphous calcium phosphate and glass ionomer show distinct effects in the remineralization of proximal artificial caries lesion in situ

• Published in: Dental Materials Journal Vol. 32; no. 4; pp. 648 - 653
• Main Authors: CHANMITKUL, Wanvipa, THEPYOU, Rathapong, THANATVARAKORN, Ornnicha, TAGAMI, Junji, TRAIRATVORAKUL, Chutima, HAMBA, Hidenori, CHOB-ISARA, Wanwalai
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Society for Dental Materials and Devices 2013; Japanese Society for Dental Materials and Devices
• Subjects: Bonding; Calcium phosphate; Cariostatic Agents - therapeutic use; Casein; Caseins - therapeutic use; Control equipment; CPP-ACP; Cross-Over Studies; Density; Dental Caries - pathology; Dental Caries - therapy; Dental Enamel - chemistry; Dental Enamel - drug effects; Dentifrices - therapeutic use; Double-Blind Method; Durapatite - analysis; Fluorides - therapeutic use; Glass; Glass Ionomer Cements - therapeutic use; Humans; Image Processing, Computer-Assisted - methods; Imaging, Three-Dimensional - methods; Ionomers; Lesions; Minerals - analysis; Phosphates - therapeutic use; Proximal caries lesion; Remineralization; Tooth Remineralization - methods; X-Ray Microtomography - methods; Young Adult
• ISSN: 0287-4547; 1881-1361; 1881-1361
• DOI: 10.4012/dmj.2012-253

This study aimed to compare the ability of casein-phosphopeptide amorphous-calcium-phosphate (CPP-ACP) and glass-ionomer (GI) in remineralizing proximal artificial caries lesions (ACLs). Molar enamel-slabs were divided into: original-lesion control, intra-oral controls, and experimental (CPP-ACP or GI) groups. Specimens received ACLs and were bonded on subject maxillary first molars. After 4-weeks, mineral density (MD) was analyzed by μCT. Compared to control, CPP-ACP increased MD at 0–38/68–84 microns and the GI group had an increase at 0–68 microns, with a greater increase in MD compared to the CPP-ACP group from 0–53 microns. The mean percent remineralization (%R) showed differences between the GI, CPP-ACP groups and their paired controls. GI tended to increase remineralization more than CPP-ACP. In conclusion, CPP-ACP and GI demonstrated distinct remineralizing ability. GI induced greater remineralization in the superficial lesion, while CPP-ACP remineralized the lesion body. Their effects on percent remineralization and reducing lesion depth of proximal ACLs were similar.