Integrated pathway mining and selection of an artificial CYP79-mediated bypass to improve benzylisoquinoline alkaloid biosynthesis - Takenaka, Musashi; Kamasaka, Kouhei; Daryong, Kim; Tsuchikane, Keiko; Miyazawa, Seiha; Fujihana, Saeko; Hori, Yoshimi; Vavricka, Christopher J.; Hosoyama, Akira; Kawasaki, Hiroko; Shirai, Tomokazu; Araki, Michihiro; et al. (Microbial Cell Factories, 2024)
Keywords: 3,4-dihydroxyphenylacetaldoxime; 3,4-Dihydroxyphenylacetic Acid - analogs & derivatives; 3,4-Dihydroxyphenylacetic Acid - metabolism; Alkaloids; Artificial metabolic pathway; Benzylisoquinoline alkaloid production; Benzylisoquinolines - metabolism; Biosynthesis; Biosynthetic Pathways; Computational enzyme mining; Computer Simulation; Cytochrome P-450 Enzyme System - metabolism; Cytochrome P450; Escherichia coli; Escherichia coli - genetics; Escherichia coli - metabolism; Hydrogen peroxide; Metabolic Engineering - methods; Microbiological research; Microbiology; Mines and mineral resources; Monoamine oxidase; Physiological aspects; Plant metabolites; QR1-502; Resveratrol; Tetrahydropapaveroline - metabolism; Tyrosine; Tyrosine N-monooxygenase; Benzylisoquinoline alkaloid production; Computational enzyme mining; Tyrosine N-monooxygenase; Cytochrome P450; 3,4-dihydroxyphenylacetaldoxime; Artificial metabolic pathway