Indirect and suboptimal control of gene expression is widespread in bacteria

• Published in: Molecular systems biology Vol. 9; no. 1; pp. 660 - n/a
• Main Authors: Price, Morgan N, Deutschbauer, Adam M, Skerker, Jeffrey M, Wetmore, Kelly M, Ruths, Troy, Mar, Jordan S, Kuehl, Jennifer V, Shao, Wenjun, Arkin, Adam P
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 2013; John Wiley & Sons, Ltd; EMBO Press; Wiley; Nature Publishing Group; Springer Nature
• Subjects: Bacteria; bacterial evolution; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; BASIC BIOLOGICAL SCIENCES; Biochemistry & Molecular Biology; Chromatin - metabolism; E coli; EMBO09; EMBO23; Environmental changes; Escherichia coli K12 - genetics; Escherichia coli K12 - metabolism; Experiments; Fitness; Gene expression; Gene Expression Profiling; Gene Expression Regulation, Bacterial; Gene regulation; Genes; Genetic Fitness; Genomes; Genomics; Growth rate; Lactose; Oligonucleotide Array Sequence Analysis; optimal regulation; Proteins; Shewanella - genetics; Shewanella - metabolism; Shewanella oneidensis; Stress, Physiological; Transcription factors; Transcription, Genetic; Zymomonas - genetics; Zymomonas - metabolism; optimal regulation; gene regulation; bacterial evolution

Gene regulation in bacteria is usually described as an adaptive response to an environmental change so that genes are expressed when they are required. We instead propose that most genes are under indirect control: their expression responds to signal(s) that are not directly related to the genes’ fu...