Folic Acid Supplementation Mitigates Alzheimer’s Disease by Reducing Inflammation: A Randomized Controlled Trial

• Published in: Mediators of inflammation Vol. 2016; no. 2016; pp. 1 - 10
• Main Authors: Huang, Guowei, Xu, Weili, Zheng, Miaoyan, Zhou, Yuying, Ji, Yong, Wu, Tianfeng, Ji, Lu, Liu, Shuai, Chen, Hui, Zhang, Meilin
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2016; John Wiley & Sons, Inc; Wiley
• Subjects: Acids; Activities of daily living; Adult; Advertising executives; Aged; Aged, 80 and over; Alzheimer Disease - drug therapy; Alzheimer Disease - immunology; Alzheimer's disease; Caregivers; Clinical Study; Clinical trials; Cognitive ability; Consent; Dementia; Female; Folic acid; Folic Acid - administration & dosage; Folic Acid - blood; Folic Acid - therapeutic use; Food science; Gene expression; Hospitals; Humans; Inflammation; Inflammation - drug therapy; Inflammation - immunology; Male; Metabolic disorders; Middle Aged; Neurology; Neurosciences; Nutrition; Older people; Public health; RNA; Single-Blind Method; Vitamin B; Vitamin B 12 - blood; China

Background/Aims. Low serum folate levels can alter inflammatory reactions. Both phenomena have been linked to Alzheimer’s disease (AD), but the effect of folic acid on AD itself is unclear. We quantified folate supplementation’s effect on inflammation and cognitive function in patients with AD over...