Host-directed therapies for infectious diseases: current status, recent progress, and future prospects

• Published in: The Lancet infectious diseases Vol. 16; no. 4; pp. e47 - e63
• Main Authors: Zumla, Alimuddin, Rao, Martin, Wallis, Robert S, Kaufmann, Stefan H E, Rustomjee, Roxana, Mwaba, Peter, Vilaplana, Cris, Yeboah-Manu, Dorothy, Chakaya, Jeremiah, Ippolito, Giuseppe, Azhar, Esam, Hoelscher, Michael, Maeurer, Markus
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 01.04.2016; Elsevier Limited
• Subjects: Antibodies, Monoclonal - therapeutic use; Bone marrow; Cell- and Tissue-Based Therapy - methods; Communicable Diseases - immunology; Communicable Diseases - therapy; Cytokines - therapeutic use; Drug Resistance; Host-Pathogen Interactions - immunology; Humans; Infectious Disease; Infectious diseases; Kinases; Lymphocytes; Malaria; Mortality; Pathogens; Public health; Tuberculosis; Tumor necrosis factor-TNF; Vector-borne diseases; Vitamins - therapeutic use

Despite extensive global efforts in the fight against killer infectious diseases, they still cause one in four deaths worldwide and are important causes of long-term functional disability arising from tissue damage. The continuing epidemics of tuberculosis, HIV, malaria, and influenza, and the emerg...